The expression of alpha(1)-acid glycoprotein mRNA during rat development. High levels of expression in the decidua
During the acute phase response to inflammation the plasma concentration of some proteins, such as alpha(1-acid glycoprotein (AGP), increases dramatically. Since breakdown and remodeling of tissue is common to both nidation and inflammation we studied the tissue distribution and regulation of AGP mR...
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| Veröffentlicht in: | The Journal of biological chemistry 1989-04, Vol.264 (10), p.5784-5790 |
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| container_end_page | 5790 |
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| container_issue | 10 |
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| container_title | The Journal of biological chemistry |
| container_volume | 264 |
| creator | THOMAS, T FLETCHER, S YEOH, G. C. T SCHREIBER, G |
| description | During the acute phase response to inflammation the plasma concentration of some proteins, such as alpha(1-acid glycoprotein
(AGP), increases dramatically. Since breakdown and remodeling of tissue is common to both nidation and inflammation we studied
the tissue distribution and regulation of AGP mRNA levels during the embryonic development of the rat. High levels of mRNA
coding for AGP were detected in the placenta during early fetal development. Expression of this mRNA was confined to the decidua
and was first observed approximately 1 day after implantation when proliferation of the decidua is already well advanced.
Maximum levels were attained about 5 days after implantation, after which the levels decreased rapidly. In contrast to the
high levels of AGP mRNA in the decidua only very low levels were detected in fetal liver and visceral yolk sac, and there
was only a small increase in the levels in maternal liver. Corticosteroid hormone responsiveness of AGP mRNA synthesis by
hepatocytes appeared 3 days before birth. It is likely that the synthesis of AGP by the cells of the decidua is important
in establishing the precisely controlled interaction between mother and embryo during nidation. |
| format | Article |
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(AGP), increases dramatically. Since breakdown and remodeling of tissue is common to both nidation and inflammation we studied
the tissue distribution and regulation of AGP mRNA levels during the embryonic development of the rat. High levels of mRNA
coding for AGP were detected in the placenta during early fetal development. Expression of this mRNA was confined to the decidua
and was first observed approximately 1 day after implantation when proliferation of the decidua is already well advanced.
Maximum levels were attained about 5 days after implantation, after which the levels decreased rapidly. In contrast to the
high levels of AGP mRNA in the decidua only very low levels were detected in fetal liver and visceral yolk sac, and there
was only a small increase in the levels in maternal liver. Corticosteroid hormone responsiveness of AGP mRNA synthesis by
hepatocytes appeared 3 days before birth. It is likely that the synthesis of AGP by the cells of the decidua is important
in establishing the precisely controlled interaction between mother and embryo during nidation.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>PMID: 2925634</identifier><identifier>CODEN: JBCHA3</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Biochemistry and Molecular Biology</publisher><subject>Aging ; Animals ; Biological and medical sciences ; Decidua - metabolism ; Embryonic and Fetal Development ; Female ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Genes ; Liver - embryology ; Liver - growth & development ; Liver - metabolism ; Molecular and cellular biology ; Molecular genetics ; Organ Specificity ; Orosomucoid - genetics ; Placenta - metabolism ; Pregnancy ; Rats ; Rats, Inbred BUF ; Rats, Inbred Strains ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Transcription, Genetic</subject><ispartof>The Journal of biological chemistry, 1989-04, Vol.264 (10), p.5784-5790</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7311517$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2925634$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>THOMAS, T</creatorcontrib><creatorcontrib>FLETCHER, S</creatorcontrib><creatorcontrib>YEOH, G. C. T</creatorcontrib><creatorcontrib>SCHREIBER, G</creatorcontrib><title>The expression of alpha(1)-acid glycoprotein mRNA during rat development. High levels of expression in the decidua</title><title>The Journal of biological chemistry</title><addtitle>J Biol Chem</addtitle><description>During the acute phase response to inflammation the plasma concentration of some proteins, such as alpha(1-acid glycoprotein
(AGP), increases dramatically. Since breakdown and remodeling of tissue is common to both nidation and inflammation we studied
the tissue distribution and regulation of AGP mRNA levels during the embryonic development of the rat. High levels of mRNA
coding for AGP were detected in the placenta during early fetal development. Expression of this mRNA was confined to the decidua
and was first observed approximately 1 day after implantation when proliferation of the decidua is already well advanced.
Maximum levels were attained about 5 days after implantation, after which the levels decreased rapidly. In contrast to the
high levels of AGP mRNA in the decidua only very low levels were detected in fetal liver and visceral yolk sac, and there
was only a small increase in the levels in maternal liver. Corticosteroid hormone responsiveness of AGP mRNA synthesis by
hepatocytes appeared 3 days before birth. It is likely that the synthesis of AGP by the cells of the decidua is important
in establishing the precisely controlled interaction between mother and embryo during nidation.</description><subject>Aging</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Decidua - metabolism</subject><subject>Embryonic and Fetal Development</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Liver - embryology</subject><subject>Liver - growth & development</subject><subject>Liver - metabolism</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Organ Specificity</subject><subject>Orosomucoid - genetics</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Inbred BUF</subject><subject>Rats, Inbred Strains</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Transcription, Genetic</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkF9LwzAUxYMoc04_ghBQRB8qSdMm6eMY6oShIBN8K2lzs0b6z6RV9-3NcIj35cI9v3vu5RygKSWSRSylb4doSkhMoyxO5TE68f6dhEoyOkGTOAw5S6bIrSvA8N078N52Le4MVnVfqWt6E6nSarypt2XXu24A2-Lm5WmO9ehsu8FODVjDJ9Rd30A73OKl3VS43k38zuafadgcwhkNwXBUp-jIqNrD2b7P0Ov93XqxjFbPD4-L-SqqqJBDlKSSE0FpoTIpGJfK8IxrA9wQAMM4NUbzWMpEFIlWMWHElGWsExIzlrIQwgxd_fqG7z9G8EPeWF9CXasWutHnQmZEZIGdofM9OBYN6Lx3tlFum-9DCvrlXle-VLVxqi2t_8MEozSlImAXv1gVgviyDvLCdmUFTR7zJKckT4VM2A8AMnw7</recordid><startdate>19890405</startdate><enddate>19890405</enddate><creator>THOMAS, T</creator><creator>FLETCHER, S</creator><creator>YEOH, G. C. T</creator><creator>SCHREIBER, G</creator><general>American Society for Biochemistry and Molecular Biology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19890405</creationdate><title>The expression of alpha(1)-acid glycoprotein mRNA during rat development. High levels of expression in the decidua</title><author>THOMAS, T ; FLETCHER, S ; YEOH, G. C. T ; SCHREIBER, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h178t-45860711ba987368af696dfe6f0eef361ffd628847b4da2030fcc2d4023353083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Decidua - metabolism</topic><topic>Embryonic and Fetal Development</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Liver - embryology</topic><topic>Liver - growth & development</topic><topic>Liver - metabolism</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Organ Specificity</topic><topic>Orosomucoid - genetics</topic><topic>Placenta - metabolism</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Inbred BUF</topic><topic>Rats, Inbred Strains</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THOMAS, T</creatorcontrib><creatorcontrib>FLETCHER, S</creatorcontrib><creatorcontrib>YEOH, G. C. T</creatorcontrib><creatorcontrib>SCHREIBER, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>THOMAS, T</au><au>FLETCHER, S</au><au>YEOH, G. C. T</au><au>SCHREIBER, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The expression of alpha(1)-acid glycoprotein mRNA during rat development. High levels of expression in the decidua</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1989-04-05</date><risdate>1989</risdate><volume>264</volume><issue>10</issue><spage>5784</spage><epage>5790</epage><pages>5784-5790</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><coden>JBCHA3</coden><abstract>During the acute phase response to inflammation the plasma concentration of some proteins, such as alpha(1-acid glycoprotein
(AGP), increases dramatically. Since breakdown and remodeling of tissue is common to both nidation and inflammation we studied
the tissue distribution and regulation of AGP mRNA levels during the embryonic development of the rat. High levels of mRNA
coding for AGP were detected in the placenta during early fetal development. Expression of this mRNA was confined to the decidua
and was first observed approximately 1 day after implantation when proliferation of the decidua is already well advanced.
Maximum levels were attained about 5 days after implantation, after which the levels decreased rapidly. In contrast to the
high levels of AGP mRNA in the decidua only very low levels were detected in fetal liver and visceral yolk sac, and there
was only a small increase in the levels in maternal liver. Corticosteroid hormone responsiveness of AGP mRNA synthesis by
hepatocytes appeared 3 days before birth. It is likely that the synthesis of AGP by the cells of the decidua is important
in establishing the precisely controlled interaction between mother and embryo during nidation.</abstract><cop>Bethesda, MD</cop><pub>American Society for Biochemistry and Molecular Biology</pub><pmid>2925634</pmid><tpages>7</tpages></addata></record> |
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| ispartof | The Journal of biological chemistry, 1989-04, Vol.264 (10), p.5784-5790 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aging Animals Biological and medical sciences Decidua - metabolism Embryonic and Fetal Development Female Fundamental and applied biological sciences. Psychology Gene expression Genes Liver - embryology Liver - growth & development Liver - metabolism Molecular and cellular biology Molecular genetics Organ Specificity Orosomucoid - genetics Placenta - metabolism Pregnancy Rats Rats, Inbred BUF Rats, Inbred Strains RNA, Messenger - genetics RNA, Messenger - metabolism Transcription, Genetic |
| title | The expression of alpha(1)-acid glycoprotein mRNA during rat development. High levels of expression in the decidua |
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