Synthesis of Cobalamin Dimers Using Isophthalate Cross-Linking of Corrin Ring Carboxylates and Evaluation of Their Binding to Transcobalamin II

Several cobalamin (Cbl) dimers have been prepared for evaluation as potential antiproliferative agents in the treatment of AIDS-related lymphoma. The Cbl dimers were synthesized by cross-linking Cbl carboxylates, produced by acid hydrolysis of the b-, d-, and e-propionamide side chains of cyanocobal...

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Veröffentlicht in:Bioconjugate chemistry 1997-03, Vol.8 (2), p.161-172
Hauptverfasser: Pathare, Pradip M, Wilbur, D. Scott, Hamlin, Donald K, Heusser, Shannon, Quadros, Edward V, McLoughlin, Patricia, Morgan, A. Charles
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Sprache:eng
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