7E3 Monoclonal Antibody Directed Against the Platelet Glycoprotein IIb/IIIa Cross-reacts With the Leukocyte Integrin Mac-1 and Blocks Adhesion to Fibrinogen and ICAM-1

Recent clinical trials suggest that blockade of integrins is a promising strategy for the treatment of acute coronary syndromes. Administration of 7E3 monoclonal antibody (mAb) Fab fragment (c7E3 Fab) directed against platelet integrin IIb/IIIa (alpha IIb beta 3, CD41/CD61) reduces acute ischemic co...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 1997-03, Vol.17 (3), p.528-535
Hauptverfasser:	Simon, Daniel I, Xu, Hui, Ortlepp, Susan, Rogers, Campbell, Rao, Navaneetha K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Biological and medical sciences Cell Adhesion - drug effects Cell interactions, adhesion Cell Line Cross Reactions Fibrinogen - metabolism Fundamental and applied biological sciences. Psychology Humans Intercellular Adhesion Molecule-1 - metabolism Macrophage-1 Antigen - immunology Molecular and cellular biology Monocytes - cytology Monocytes - drug effects Monocytes - metabolism Platelet Glycoprotein GPIIb-IIIa Complex - immunology
Online-Zugang:	Volltext
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