The combined effect of interferon and 5-FU on tumor-cell metastasis in the nude mouse
In searching for a suitable animal model system to study colorectal tumor-cell metastasis, the method of injecting tumor cells directly into the spleen of athymic nude mice was explored. The cells used in this study consisted of the Colo 205 cell line, isolated and established from the ascitic fluid...
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| Veröffentlicht in: | Diseases of the colon & rectum 1989-04, Vol.32 (4), p.340-343 |
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| container_title | Diseases of the colon & rectum |
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| creator | BIRSIC, W D'ORO, L SURIN CHAROENSIRI KATOH, A |
| description | In searching for a suitable animal model system to study colorectal tumor-cell metastasis, the method of injecting tumor cells directly into the spleen of athymic nude mice was explored. The cells used in this study consisted of the Colo 205 cell line, isolated and established from the ascitic fluid of a patient with adenocarcinoma of the colon. In spite of showing tumorigenicity in nude mice after subcutaneous injections, anchorage-independent clonal growth in soft agar, and invasion in the chick embryo skin, the Colo 205 cells failed to metastasize to the lung or liver after intrasplenic injections. The effects of interferon, and interferon in combination with 5-fluorouracil (5-FU), on tumor formation in the spleen, were studied. The combined interferon- and 5-FU-treated animals displayed a significant difference from the controls in the generation of spleen tumors. This combination may possess potentially useful applications in the treatment of solid tumors such as those in the colon and rectum. |
| doi_str_mv | 10.1007/BF02553491 |
| format | Article |
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The cells used in this study consisted of the Colo 205 cell line, isolated and established from the ascitic fluid of a patient with adenocarcinoma of the colon. In spite of showing tumorigenicity in nude mice after subcutaneous injections, anchorage-independent clonal growth in soft agar, and invasion in the chick embryo skin, the Colo 205 cells failed to metastasize to the lung or liver after intrasplenic injections. The effects of interferon, and interferon in combination with 5-fluorouracil (5-FU), on tumor formation in the spleen, were studied. The combined interferon- and 5-FU-treated animals displayed a significant difference from the controls in the generation of spleen tumors. This combination may possess potentially useful applications in the treatment of solid tumors such as those in the colon and rectum.</description><identifier>ISSN: 0012-3706</identifier><identifier>EISSN: 1530-0358</identifier><identifier>DOI: 10.1007/BF02553491</identifier><identifier>PMID: 2466622</identifier><identifier>CODEN: DICRAG</identifier><language>eng</language><publisher>Secaucus, NJ: Springer</publisher><subject>Adenocarcinoma - drug therapy ; Adenocarcinoma - pathology ; Adenocarcinoma - therapy ; Animals ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Colorectal Neoplasms - drug therapy ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - therapy ; Fluorouracil - administration & dosage ; Interferons - administration & dosage ; Liver Neoplasms - secondary ; Lung Neoplasms - secondary ; Medical sciences ; Mice ; Mice, Nude ; Neuropharmacology ; Pharmacology. 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The cells used in this study consisted of the Colo 205 cell line, isolated and established from the ascitic fluid of a patient with adenocarcinoma of the colon. In spite of showing tumorigenicity in nude mice after subcutaneous injections, anchorage-independent clonal growth in soft agar, and invasion in the chick embryo skin, the Colo 205 cells failed to metastasize to the lung or liver after intrasplenic injections. The effects of interferon, and interferon in combination with 5-fluorouracil (5-FU), on tumor formation in the spleen, were studied. The combined interferon- and 5-FU-treated animals displayed a significant difference from the controls in the generation of spleen tumors. This combination may possess potentially useful applications in the treatment of solid tumors such as those in the colon and rectum.</description><subject>Adenocarcinoma - drug therapy</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - therapy</subject><subject>Animals</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - therapy</subject><subject>Fluorouracil - administration & dosage</subject><subject>Interferons - administration & dosage</subject><subject>Liver Neoplasms - secondary</subject><subject>Lung Neoplasms - secondary</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Tumor Cells, Cultured</subject><issn>0012-3706</issn><issn>1530-0358</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLw0AUhQdRaq1u3AuzEBdC9M4zydIWq0LBTbsOk8kdjORRZ5KF_94pDRUu98H9OBwOIbcMnhhA-rxcA1dKyJydkTlTAhIQKjsncwDGE5GCviRXIXzHEzikMzLjUmvN-Zzstl9Ibd-WdYcVRefQDrR3tO4G9A5931HTVVQl6x2N-zC2vU8sNg1tcTAhVh0iTIco040V0rYfA16TC2eagDfTXJDd-nW7ek82n28fq5dNYgVjQyJQZxxLZpGhtQjCCKu0Tm3lcsatctLEpvJccgGytExqJ3XpcuVymUkrFuThqLv3_c-IYSjaOhzcmQ6jjyLNckgZZBF8PILW9yF4dMXe163xvwWD4pBh8Z9hhO8m1bFssTqhU2jxfz_9TbCmcd50tg4nLOWZ1CwTfzc6d3M</recordid><startdate>19890401</startdate><enddate>19890401</enddate><creator>BIRSIC, W</creator><creator>D'ORO, L</creator><creator>SURIN CHAROENSIRI</creator><creator>KATOH, A</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890401</creationdate><title>The combined effect of interferon and 5-FU on tumor-cell metastasis in the nude mouse</title><author>BIRSIC, W ; D'ORO, L ; SURIN CHAROENSIRI ; KATOH, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-3e682eb1ce1ecce03a3c5667cdf912c5f4ac5f59942304bc146f46bf95f9484c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adenocarcinoma - drug therapy</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - therapy</topic><topic>Animals</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - therapy</topic><topic>Fluorouracil - administration & dosage</topic><topic>Interferons - administration & dosage</topic><topic>Liver Neoplasms - secondary</topic><topic>Lung Neoplasms - secondary</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BIRSIC, W</creatorcontrib><creatorcontrib>D'ORO, L</creatorcontrib><creatorcontrib>SURIN CHAROENSIRI</creatorcontrib><creatorcontrib>KATOH, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diseases of the colon & rectum</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BIRSIC, W</au><au>D'ORO, L</au><au>SURIN CHAROENSIRI</au><au>KATOH, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The combined effect of interferon and 5-FU on tumor-cell metastasis in the nude mouse</atitle><jtitle>Diseases of the colon & rectum</jtitle><addtitle>Dis Colon Rectum</addtitle><date>1989-04-01</date><risdate>1989</risdate><volume>32</volume><issue>4</issue><spage>340</spage><epage>343</epage><pages>340-343</pages><issn>0012-3706</issn><eissn>1530-0358</eissn><coden>DICRAG</coden><abstract>In searching for a suitable animal model system to study colorectal tumor-cell metastasis, the method of injecting tumor cells directly into the spleen of athymic nude mice was explored. The cells used in this study consisted of the Colo 205 cell line, isolated and established from the ascitic fluid of a patient with adenocarcinoma of the colon. In spite of showing tumorigenicity in nude mice after subcutaneous injections, anchorage-independent clonal growth in soft agar, and invasion in the chick embryo skin, the Colo 205 cells failed to metastasize to the lung or liver after intrasplenic injections. The effects of interferon, and interferon in combination with 5-fluorouracil (5-FU), on tumor formation in the spleen, were studied. The combined interferon- and 5-FU-treated animals displayed a significant difference from the controls in the generation of spleen tumors. This combination may possess potentially useful applications in the treatment of solid tumors such as those in the colon and rectum.</abstract><cop>Secaucus, NJ</cop><pub>Springer</pub><pmid>2466622</pmid><doi>10.1007/BF02553491</doi><tpages>4</tpages></addata></record> |
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| ispartof | Diseases of the colon & rectum, 1989-04, Vol.32 (4), p.340-343 |
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| subjects | Adenocarcinoma - drug therapy Adenocarcinoma - pathology Adenocarcinoma - therapy Animals Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Fluorouracil - administration & dosage Interferons - administration & dosage Liver Neoplasms - secondary Lung Neoplasms - secondary Medical sciences Mice Mice, Nude Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Tumor Cells, Cultured |
| title | The combined effect of interferon and 5-FU on tumor-cell metastasis in the nude mouse |
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