The percutaneous absorption of topically applied tretinoin and its effect on endogenous concentrations of tretinoin and its metabolites after single doses or long-term use

Background: The percutaneous absorption of topically applied tretinoin cream and emollient cream formulations has not been comprehensively studied. Objective: To assess tretinoin absorption and plasma levels of tretinoin and its metabolites after single and repeated topical tretinoin doses. Methods:...

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