Doppler characterization of left ventricular diastolic function in cardiac amyloidosis
Sixty-four patients with primary systemic amyloidosis—53 with two-dimensional echocardiographic features of cardiac involvement (Group I) and 11 without cardiac involvement (Group II)—underwent Doppler echocardiographic assessment of left ventricular diastolic function. Pulsed wave Doppler recording...
Gespeichert in:
| Veröffentlicht in: | Journal of the American College of Cardiology 1989-04, Vol.13 (5), p.1017-1026 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1026 |
|---|---|
| container_issue | 5 |
| container_start_page | 1017 |
| container_title | Journal of the American College of Cardiology |
| container_volume | 13 |
| creator | Klein, Allan L. Hatle, Liv K. Burstow, Darryl J. Seward, James B. Kyle, Robert A. Bailey, Kent R. Luscher, Thomas F. Gertz, Morie A. Jamil Tajik, A. |
| description | Sixty-four patients with primary systemic amyloidosis—53 with two-dimensional echocardiographic features of cardiac involvement (Group I) and 11 without cardiac involvement (Group II)—underwent Doppler echocardiographic assessment of left ventricular diastolic function. Pulsed wave Doppler recordings of left ventricular inflow velocities and pulmonary vein flow velocities with respiratory monitoring in these patients were compared with findings in a normal group.
Patients in Group I showed striking abnormalities of left ventricular diastolic filling when classified into subgroups by mean left ventricular wall thickness: early >12 but |
| doi_str_mv | 10.1016/0735-1097(89)90254-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78905616</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0735109789902544</els_id><sourcerecordid>78905616</sourcerecordid><originalsourceid>FETCH-LOGICAL-c533t-19fb96ea595fffe760c910a2adeec543d6f852eb0e27d0edc16223cb9764fe073</originalsourceid><addsrcrecordid>eNp9kMtKxDAUhoMoOl7eQKELEV1Uk7ZJmo0g3kFwo25D5uQEI5lmTFpBn96OM8zS1Vn837l9hBwyes4oExdU1rxkVMnTVp0pWvGmbDbIhHHeljVXcpNM1sgO2c35g1IqWqa2yXYlGtmyZkLebuJ8HjAV8G6SgR6T_zG9j10RXRHQ9cUXdn3yMASTCutN7mPwULihgz_MdwWYNAZQmNl3iN7G7PM-2XImZDxY1T3yenf7cv1QPj3fP15fPZXA67ovmXJTJdBwxZ1zKAUFxaipjEUE3tRWuJZXOKVYSUvRAhNVVcNUSdE4HL_bIyfLufMUPwfMvZ75DBiC6TAOWctWUS6YGMFmCUKKOSd0ep78zKRvzahe6NQLV3rhSrdK_-nUzdh2tJo_TGdo100rf2N-vMpNBhNcMh34vMYkk1SpxfbLJYajiy-PSWfw2AFanxB6baP__45fu82S4g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78905616</pqid></control><display><type>article</type><title>Doppler characterization of left ventricular diastolic function in cardiac amyloidosis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Klein, Allan L. ; Hatle, Liv K. ; Burstow, Darryl J. ; Seward, James B. ; Kyle, Robert A. ; Bailey, Kent R. ; Luscher, Thomas F. ; Gertz, Morie A. ; Jamil Tajik, A.</creator><creatorcontrib>Klein, Allan L. ; Hatle, Liv K. ; Burstow, Darryl J. ; Seward, James B. ; Kyle, Robert A. ; Bailey, Kent R. ; Luscher, Thomas F. ; Gertz, Morie A. ; Jamil Tajik, A.</creatorcontrib><description><![CDATA[Sixty-four patients with primary systemic amyloidosis—53 with two-dimensional echocardiographic features of cardiac involvement (Group I) and 11 without cardiac involvement (Group II)—underwent Doppler echocardiographic assessment of left ventricular diastolic function. Pulsed wave Doppler recordings of left ventricular inflow velocities and pulmonary vein flow velocities with respiratory monitoring in these patients were compared with findings in a normal group.
Patients in Group I showed striking abnormalities of left ventricular diastolic filling when classified into subgroups by mean left ventricular wall thickness: early >12 but <15 mm; advanced ≥15 mm. In early amyloidosis, relaxation was abnormal, with decreased peak early velocity (75 ± 20 versus 86 ± 16 cm/s; p < 0.01), increased late velocity (71 ± 22 versus 56 ± 13 cm/s; p < 0.01), decreased early to late velocity ratio (1.2 ± 0.6 versus 1.6 ± 0.5; p < 0.01) and prolonged isovolumic relaxation time (87 ± 15 versus 73 ± 13 ms; p < 0.01) compared with normal values. In advanced amyloidosis, there was a restrictive filling pattern with a markedly shortened deceleration time (148 ± 50 versus 199 ± 32 ms; p < 0.001), decreased pulmonary vein peak systolic flow velocity (34 ± 16 versus 54 ± 2 cm/s; p < 0.01) and increased diastolic flow velocity (55 ± 20 versus 44 ± 12 cm/s; p < 0.01) compared with normal values. Group II and the subgroup with early amyloidosis had similar flow velocity patterns.
Thus, this study documents that in cardiac amyloidosis, a spectrum of diastolic filling abnormalities exists; the restrictive filling pattern is seen only in the advanced stages.]]></description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/0735-1097(89)90254-4</identifier><identifier>PMID: 2647814</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Amyloidosis ; Amyloidosis - complications ; Amyloidosis - pathology ; Amyloidosis - physiopathology ; Biological and medical sciences ; Blood Flow Velocity ; Coronary Circulation ; Diastole ; Echocardiography ; Female ; Heart - physiopathology ; Heart Diseases - complications ; Heart Diseases - physiopathology ; Heart Ventricles ; Humans ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Mitral Valve Insufficiency - complications ; Myocardial Contraction ; Myocardium - pathology ; Other metabolic disorders ; Pulmonary Veins - physiopathology ; Systole ; Ultrasonography</subject><ispartof>Journal of the American College of Cardiology, 1989-04, Vol.13 (5), p.1017-1026</ispartof><rights>1989</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-19fb96ea595fffe760c910a2adeec543d6f852eb0e27d0edc16223cb9764fe073</citedby><cites>FETCH-LOGICAL-c533t-19fb96ea595fffe760c910a2adeec543d6f852eb0e27d0edc16223cb9764fe073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0735109789902544$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7170996$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2647814$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klein, Allan L.</creatorcontrib><creatorcontrib>Hatle, Liv K.</creatorcontrib><creatorcontrib>Burstow, Darryl J.</creatorcontrib><creatorcontrib>Seward, James B.</creatorcontrib><creatorcontrib>Kyle, Robert A.</creatorcontrib><creatorcontrib>Bailey, Kent R.</creatorcontrib><creatorcontrib>Luscher, Thomas F.</creatorcontrib><creatorcontrib>Gertz, Morie A.</creatorcontrib><creatorcontrib>Jamil Tajik, A.</creatorcontrib><title>Doppler characterization of left ventricular diastolic function in cardiac amyloidosis</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description><![CDATA[Sixty-four patients with primary systemic amyloidosis—53 with two-dimensional echocardiographic features of cardiac involvement (Group I) and 11 without cardiac involvement (Group II)—underwent Doppler echocardiographic assessment of left ventricular diastolic function. Pulsed wave Doppler recordings of left ventricular inflow velocities and pulmonary vein flow velocities with respiratory monitoring in these patients were compared with findings in a normal group.
Patients in Group I showed striking abnormalities of left ventricular diastolic filling when classified into subgroups by mean left ventricular wall thickness: early >12 but <15 mm; advanced ≥15 mm. In early amyloidosis, relaxation was abnormal, with decreased peak early velocity (75 ± 20 versus 86 ± 16 cm/s; p < 0.01), increased late velocity (71 ± 22 versus 56 ± 13 cm/s; p < 0.01), decreased early to late velocity ratio (1.2 ± 0.6 versus 1.6 ± 0.5; p < 0.01) and prolonged isovolumic relaxation time (87 ± 15 versus 73 ± 13 ms; p < 0.01) compared with normal values. In advanced amyloidosis, there was a restrictive filling pattern with a markedly shortened deceleration time (148 ± 50 versus 199 ± 32 ms; p < 0.001), decreased pulmonary vein peak systolic flow velocity (34 ± 16 versus 54 ± 2 cm/s; p < 0.01) and increased diastolic flow velocity (55 ± 20 versus 44 ± 12 cm/s; p < 0.01) compared with normal values. Group II and the subgroup with early amyloidosis had similar flow velocity patterns.
Thus, this study documents that in cardiac amyloidosis, a spectrum of diastolic filling abnormalities exists; the restrictive filling pattern is seen only in the advanced stages.]]></description><subject>Amyloidosis</subject><subject>Amyloidosis - complications</subject><subject>Amyloidosis - pathology</subject><subject>Amyloidosis - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Coronary Circulation</subject><subject>Diastole</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Heart - physiopathology</subject><subject>Heart Diseases - complications</subject><subject>Heart Diseases - physiopathology</subject><subject>Heart Ventricles</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Mitral Valve Insufficiency - complications</subject><subject>Myocardial Contraction</subject><subject>Myocardium - pathology</subject><subject>Other metabolic disorders</subject><subject>Pulmonary Veins - physiopathology</subject><subject>Systole</subject><subject>Ultrasonography</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMoOl7eQKELEV1Uk7ZJmo0g3kFwo25D5uQEI5lmTFpBn96OM8zS1Vn837l9hBwyes4oExdU1rxkVMnTVp0pWvGmbDbIhHHeljVXcpNM1sgO2c35g1IqWqa2yXYlGtmyZkLebuJ8HjAV8G6SgR6T_zG9j10RXRHQ9cUXdn3yMASTCutN7mPwULihgz_MdwWYNAZQmNl3iN7G7PM-2XImZDxY1T3yenf7cv1QPj3fP15fPZXA67ovmXJTJdBwxZ1zKAUFxaipjEUE3tRWuJZXOKVYSUvRAhNVVcNUSdE4HL_bIyfLufMUPwfMvZ75DBiC6TAOWctWUS6YGMFmCUKKOSd0ep78zKRvzahe6NQLV3rhSrdK_-nUzdh2tJo_TGdo100rf2N-vMpNBhNcMh34vMYkk1SpxfbLJYajiy-PSWfw2AFanxB6baP__45fu82S4g</recordid><startdate>19890401</startdate><enddate>19890401</enddate><creator>Klein, Allan L.</creator><creator>Hatle, Liv K.</creator><creator>Burstow, Darryl J.</creator><creator>Seward, James B.</creator><creator>Kyle, Robert A.</creator><creator>Bailey, Kent R.</creator><creator>Luscher, Thomas F.</creator><creator>Gertz, Morie A.</creator><creator>Jamil Tajik, A.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890401</creationdate><title>Doppler characterization of left ventricular diastolic function in cardiac amyloidosis</title><author>Klein, Allan L. ; Hatle, Liv K. ; Burstow, Darryl J. ; Seward, James B. ; Kyle, Robert A. ; Bailey, Kent R. ; Luscher, Thomas F. ; Gertz, Morie A. ; Jamil Tajik, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-19fb96ea595fffe760c910a2adeec543d6f852eb0e27d0edc16223cb9764fe073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Amyloidosis</topic><topic>Amyloidosis - complications</topic><topic>Amyloidosis - pathology</topic><topic>Amyloidosis - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Blood Flow Velocity</topic><topic>Coronary Circulation</topic><topic>Diastole</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Heart - physiopathology</topic><topic>Heart Diseases - complications</topic><topic>Heart Diseases - physiopathology</topic><topic>Heart Ventricles</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Mitral Valve Insufficiency - complications</topic><topic>Myocardial Contraction</topic><topic>Myocardium - pathology</topic><topic>Other metabolic disorders</topic><topic>Pulmonary Veins - physiopathology</topic><topic>Systole</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klein, Allan L.</creatorcontrib><creatorcontrib>Hatle, Liv K.</creatorcontrib><creatorcontrib>Burstow, Darryl J.</creatorcontrib><creatorcontrib>Seward, James B.</creatorcontrib><creatorcontrib>Kyle, Robert A.</creatorcontrib><creatorcontrib>Bailey, Kent R.</creatorcontrib><creatorcontrib>Luscher, Thomas F.</creatorcontrib><creatorcontrib>Gertz, Morie A.</creatorcontrib><creatorcontrib>Jamil Tajik, A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klein, Allan L.</au><au>Hatle, Liv K.</au><au>Burstow, Darryl J.</au><au>Seward, James B.</au><au>Kyle, Robert A.</au><au>Bailey, Kent R.</au><au>Luscher, Thomas F.</au><au>Gertz, Morie A.</au><au>Jamil Tajik, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Doppler characterization of left ventricular diastolic function in cardiac amyloidosis</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>1989-04-01</date><risdate>1989</risdate><volume>13</volume><issue>5</issue><spage>1017</spage><epage>1026</epage><pages>1017-1026</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract><![CDATA[Sixty-four patients with primary systemic amyloidosis—53 with two-dimensional echocardiographic features of cardiac involvement (Group I) and 11 without cardiac involvement (Group II)—underwent Doppler echocardiographic assessment of left ventricular diastolic function. Pulsed wave Doppler recordings of left ventricular inflow velocities and pulmonary vein flow velocities with respiratory monitoring in these patients were compared with findings in a normal group.
Patients in Group I showed striking abnormalities of left ventricular diastolic filling when classified into subgroups by mean left ventricular wall thickness: early >12 but <15 mm; advanced ≥15 mm. In early amyloidosis, relaxation was abnormal, with decreased peak early velocity (75 ± 20 versus 86 ± 16 cm/s; p < 0.01), increased late velocity (71 ± 22 versus 56 ± 13 cm/s; p < 0.01), decreased early to late velocity ratio (1.2 ± 0.6 versus 1.6 ± 0.5; p < 0.01) and prolonged isovolumic relaxation time (87 ± 15 versus 73 ± 13 ms; p < 0.01) compared with normal values. In advanced amyloidosis, there was a restrictive filling pattern with a markedly shortened deceleration time (148 ± 50 versus 199 ± 32 ms; p < 0.001), decreased pulmonary vein peak systolic flow velocity (34 ± 16 versus 54 ± 2 cm/s; p < 0.01) and increased diastolic flow velocity (55 ± 20 versus 44 ± 12 cm/s; p < 0.01) compared with normal values. Group II and the subgroup with early amyloidosis had similar flow velocity patterns.
Thus, this study documents that in cardiac amyloidosis, a spectrum of diastolic filling abnormalities exists; the restrictive filling pattern is seen only in the advanced stages.]]></abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2647814</pmid><doi>10.1016/0735-1097(89)90254-4</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-1097 |
| ispartof | Journal of the American College of Cardiology, 1989-04, Vol.13 (5), p.1017-1026 |
| issn | 0735-1097 1558-3597 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78905616 |
| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Amyloidosis Amyloidosis - complications Amyloidosis - pathology Amyloidosis - physiopathology Biological and medical sciences Blood Flow Velocity Coronary Circulation Diastole Echocardiography Female Heart - physiopathology Heart Diseases - complications Heart Diseases - physiopathology Heart Ventricles Humans Male Medical sciences Metabolic diseases Middle Aged Mitral Valve Insufficiency - complications Myocardial Contraction Myocardium - pathology Other metabolic disorders Pulmonary Veins - physiopathology Systole Ultrasonography |
| title | Doppler characterization of left ventricular diastolic function in cardiac amyloidosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T16%3A12%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Doppler%20characterization%20of%20left%20ventricular%20diastolic%20function%20in%20cardiac%20amyloidosis&rft.jtitle=Journal%20of%20the%20American%20College%20of%20Cardiology&rft.au=Klein,%20Allan%20L.&rft.date=1989-04-01&rft.volume=13&rft.issue=5&rft.spage=1017&rft.epage=1026&rft.pages=1017-1026&rft.issn=0735-1097&rft.eissn=1558-3597&rft.coden=JACCDI&rft_id=info:doi/10.1016/0735-1097(89)90254-4&rft_dat=%3Cproquest_cross%3E78905616%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78905616&rft_id=info:pmid/2647814&rft_els_id=0735109789902544&rfr_iscdi=true |