The PIT-1 Gene Is Regulated by Distinct Early and Late Pituitary-Specific Enhancers

The differentiation of three anterior pituitary cell types is regulated by the tissue-specific POU domain factor Pit-1, which is initially expressed on Embryonic Day 13.5–14 in mice. The Pit-1gene remains continuously, highly expressed in the somatotrope, thyrotrope, and lactotrope cells of the adul...

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Veröffentlicht in:	Developmental biology 1997-02, Vol.182 (1), p.180-190
Hauptverfasser:	DiMattia, Gabriel E., Rhodes, Simon J., Krones, Anna, Carrière, Catherine, O'Connell, Shawn, Kalla, Kristin, Arias, Carlos, Sawchenko, Paul, Rosenfeld, Michael G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA-Binding Proteins - biosynthesis Dwarfism - genetics Enhancer Elements, Genetic Gene Expression Regulation, Developmental Homeodomain Proteins - biosynthesis Human Growth Hormone - biosynthesis Human Growth Hormone - genetics Humans Mice Mice, Mutant Strains Mice, Transgenic Organ Specificity Pituitary Gland, Anterior - embryology Pituitary Gland, Anterior - metabolism Recombinant Fusion Proteins - biosynthesis Transcription Factor Pit-1 Transcription Factors - biosynthesis Transcriptional Activation
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