Molecular Determinants of Agonist Discrimination by NMDA Receptor Subunits: Analysis of the Glutamate Binding Site on the NR2B Subunit

NMDA receptors require both L-glutamate and the coagonist glycine for efficient channel activation. The glycine binding site of these heteromeric receptor proteins is formed by regions of the NMDAR1 (NR1) subunit that display sequence similarity to bacterial amino acid binding proteins. Here, we dem...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 1997-03, Vol.18 (3), p.493-503
Hauptverfasser:	Laube, Bodo, Hirai, Hirokazu, Sturgess, Mike, Betz, Heinrich, Kuhse, Jochen
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-5-phosphonovalerate - pharmacology Amino Acid Sequence Binding Sites Excitatory Amino Acid Agonists - pharmacology Glutamic Acid - metabolism Glutamic Acid - pharmacology Glycine - pharmacology Ion Channel Gating - drug effects Models, Molecular Molecular Sequence Data Piperazines - pharmacology Receptors, N-Methyl-D-Aspartate - agonists Receptors, N-Methyl-D-Aspartate - chemistry Receptors, N-Methyl-D-Aspartate - metabolism Sequence Alignment Sequence Homology, Amino Acid
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