Detection of C-type natriuretic peptide (CNP) and atrial natriuretic peptide (ANP-B) receptor mRNAs in rat inner ear
C-TYPE natriuretic peptide (CNP) is the third member of the natriuretic peptide family which plays an important role in body fluid homeostasis. To determine a possible role of CNP in regulation of an inner ear fluid, we investigated the expression of CNP and atrial natriuretic peptide B receptor (AN...
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| Veröffentlicht in: | Neuroreport 1997-01, Vol.8 (2), p.439-443 |
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| container_title | Neuroreport |
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| creator | Suzuki, Mikio Kitano, Hiroya Kitanishi, Tsuyoshi Yazawa, Yoshiro Kitajima, Kazutomo Takeda, Taizou Kimura, Hiroshi Tooyama, Ikuo |
| description | C-TYPE natriuretic peptide (CNP) is the third member of the natriuretic peptide family which plays an important role in body fluid homeostasis. To determine a possible role of CNP in regulation of an inner ear fluid, we investigated the expression of CNP and atrial natriuretic peptide B receptor (ANP-B receptor) mRNAs in rat inner ear using a reverse transcription polymerase chain reaction (RT-PCR) method. Amplification products with sizes expected for CNP and ANP-B were detected in the inner ear. After cloning and analysis, the sequences for PCR products were identical to those of CNP or ANP-B receptor in the brain. These results indicate that both CNP and ANP-B receptor are expressed in the inner ear of the rat and suggest that CNP may play a role in inner ear function (such as regulation of inner ear fluid) in an autocrine and/or paracrine manner. |
| doi_str_mv | 10.1097/00001756-199701200-00013 |
| format | Article |
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To determine a possible role of CNP in regulation of an inner ear fluid, we investigated the expression of CNP and atrial natriuretic peptide B receptor (ANP-B receptor) mRNAs in rat inner ear using a reverse transcription polymerase chain reaction (RT-PCR) method. Amplification products with sizes expected for CNP and ANP-B were detected in the inner ear. After cloning and analysis, the sequences for PCR products were identical to those of CNP or ANP-B receptor in the brain. These results indicate that both CNP and ANP-B receptor are expressed in the inner ear of the rat and suggest that CNP may play a role in inner ear function (such as regulation of inner ear fluid) in an autocrine and/or paracrine manner.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199701200-00013</identifier><identifier>PMID: 9080425</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Animals ; Base Sequence ; Biological and medical sciences ; Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation ; Ear, Inner - metabolism ; Fundamental and applied biological sciences. Psychology ; Guanylate Cyclase - metabolism ; Male ; Molecular Sequence Data ; Polymerase Chain Reaction ; Rats ; Rats, Wistar ; Receptors, Atrial Natriuretic Factor - metabolism ; RNA, Messenger - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 1997-01, Vol.8 (2), p.439-443</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3823-ed68c8f199e77400f30478e4abbed1d4bad055942621e6b94e738a9a95f81b123</citedby><cites>FETCH-LOGICAL-c3823-ed68c8f199e77400f30478e4abbed1d4bad055942621e6b94e738a9a95f81b123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2589917$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9080425$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suzuki, Mikio</creatorcontrib><creatorcontrib>Kitano, Hiroya</creatorcontrib><creatorcontrib>Kitanishi, Tsuyoshi</creatorcontrib><creatorcontrib>Yazawa, Yoshiro</creatorcontrib><creatorcontrib>Kitajima, Kazutomo</creatorcontrib><creatorcontrib>Takeda, Taizou</creatorcontrib><creatorcontrib>Kimura, Hiroshi</creatorcontrib><creatorcontrib>Tooyama, Ikuo</creatorcontrib><title>Detection of C-type natriuretic peptide (CNP) and atrial natriuretic peptide (ANP-B) receptor mRNAs in rat inner ear</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>C-TYPE natriuretic peptide (CNP) is the third member of the natriuretic peptide family which plays an important role in body fluid homeostasis. To determine a possible role of CNP in regulation of an inner ear fluid, we investigated the expression of CNP and atrial natriuretic peptide B receptor (ANP-B receptor) mRNAs in rat inner ear using a reverse transcription polymerase chain reaction (RT-PCR) method. Amplification products with sizes expected for CNP and ANP-B were detected in the inner ear. After cloning and analysis, the sequences for PCR products were identical to those of CNP or ANP-B receptor in the brain. These results indicate that both CNP and ANP-B receptor are expressed in the inner ear of the rat and suggest that CNP may play a role in inner ear function (such as regulation of inner ear fluid) in an autocrine and/or paracrine manner.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</subject><subject>Ear, Inner - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guanylate Cyclase - metabolism</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>Polymerase Chain Reaction</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Atrial Natriuretic Factor - metabolism</subject><subject>RNA, Messenger - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v3CAQhlHUKt18_IRIHKoqOdCCAQPHzTYflaJNFCVSbgjjseLWazuAFeXfl81u9tRyGWneZxjxgBBm9DujRv2g-TAlS8KMUZQVlJJ1h--hGROKEyn10yc0o0YaIkwpv6CDGH9nxFCm99G-oZqKQs5Q-gkJfGqHHg8NXpD0NgLuXQrtFCC1Ho8wprYGfLpY3p1h19d4Hbru39B8eUfOz3AAnztDwKv75TzitsfBpVx6CBhcOEKfG9dFON7WQ_R4efGwuCY3t1e_FvMb4rkuOIG61F43-YmglKC04VQoDcJVFdSsFpWrqZRGFGXBoKyMAMW1M87IRrOKFfwQfdvcO4bhZYKY7KqNHrrO9TBM0SptKOdMZlBvQB-GGAM0dgztyoU3y6hdC7cfwu1OuH0XnkdPtjumagX1bnBrOOdft7mL3nVNcL1v4w4rpDaGqYyJDfY6dAlC_NNNrxDsM7guPdv_fTf_C-otloc</recordid><startdate>19970120</startdate><enddate>19970120</enddate><creator>Suzuki, Mikio</creator><creator>Kitano, Hiroya</creator><creator>Kitanishi, Tsuyoshi</creator><creator>Yazawa, Yoshiro</creator><creator>Kitajima, Kazutomo</creator><creator>Takeda, Taizou</creator><creator>Kimura, Hiroshi</creator><creator>Tooyama, Ikuo</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970120</creationdate><title>Detection of C-type natriuretic peptide (CNP) and atrial natriuretic peptide (ANP-B) receptor mRNAs in rat inner ear</title><author>Suzuki, Mikio ; Kitano, Hiroya ; Kitanishi, Tsuyoshi ; Yazawa, Yoshiro ; Kitajima, Kazutomo ; Takeda, Taizou ; Kimura, Hiroshi ; Tooyama, Ikuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3823-ed68c8f199e77400f30478e4abbed1d4bad055942621e6b94e738a9a95f81b123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</topic><topic>Ear, Inner - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guanylate Cyclase - metabolism</topic><topic>Male</topic><topic>Molecular Sequence Data</topic><topic>Polymerase Chain Reaction</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Atrial Natriuretic Factor - metabolism</topic><topic>RNA, Messenger - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzuki, Mikio</creatorcontrib><creatorcontrib>Kitano, Hiroya</creatorcontrib><creatorcontrib>Kitanishi, Tsuyoshi</creatorcontrib><creatorcontrib>Yazawa, Yoshiro</creatorcontrib><creatorcontrib>Kitajima, Kazutomo</creatorcontrib><creatorcontrib>Takeda, Taizou</creatorcontrib><creatorcontrib>Kimura, Hiroshi</creatorcontrib><creatorcontrib>Tooyama, Ikuo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzuki, Mikio</au><au>Kitano, Hiroya</au><au>Kitanishi, Tsuyoshi</au><au>Yazawa, Yoshiro</au><au>Kitajima, Kazutomo</au><au>Takeda, Taizou</au><au>Kimura, Hiroshi</au><au>Tooyama, Ikuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of C-type natriuretic peptide (CNP) and atrial natriuretic peptide (ANP-B) receptor mRNAs in rat inner ear</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1997-01-20</date><risdate>1997</risdate><volume>8</volume><issue>2</issue><spage>439</spage><epage>443</epage><pages>439-443</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>C-TYPE natriuretic peptide (CNP) is the third member of the natriuretic peptide family which plays an important role in body fluid homeostasis. To determine a possible role of CNP in regulation of an inner ear fluid, we investigated the expression of CNP and atrial natriuretic peptide B receptor (ANP-B receptor) mRNAs in rat inner ear using a reverse transcription polymerase chain reaction (RT-PCR) method. Amplification products with sizes expected for CNP and ANP-B were detected in the inner ear. After cloning and analysis, the sequences for PCR products were identical to those of CNP or ANP-B receptor in the brain. These results indicate that both CNP and ANP-B receptor are expressed in the inner ear of the rat and suggest that CNP may play a role in inner ear function (such as regulation of inner ear fluid) in an autocrine and/or paracrine manner.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9080425</pmid><doi>10.1097/00001756-199701200-00013</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neuroreport, 1997-01, Vol.8 (2), p.439-443 |
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| language | eng |
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| subjects | Animals Base Sequence Biological and medical sciences Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Ear, Inner - metabolism Fundamental and applied biological sciences. Psychology Guanylate Cyclase - metabolism Male Molecular Sequence Data Polymerase Chain Reaction Rats Rats, Wistar Receptors, Atrial Natriuretic Factor - metabolism RNA, Messenger - metabolism Vertebrates: nervous system and sense organs |
| title | Detection of C-type natriuretic peptide (CNP) and atrial natriuretic peptide (ANP-B) receptor mRNAs in rat inner ear |
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