Hydrogen Tunneling in Enzyme Reactions

Primary and secondary protium-to-tritium (H/T) and deuterium-to-tritium (D/T) kinetic isotope effects for the catalytic oxidation of benzyl alcohol to benzaldehyde by yeast alcohol dehydrogenase (YADH) at 25 degrees Celsius have been determined. Previous studies showed that this reaction is nearly o...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1989-03, Vol.243 (4896), p.1325-1330
Hauptverfasser:	Cha, Yuan, Murray, Christopher J., Klinman, Judith P.
Format:	Artikel
Sprache:	eng
Schlagworte:	550501 - Metabolism- Tracer Techniques ALCOHOL DEHYDROGENASE Alcohol Dehydrogenase - metabolism ALCOHOLS ALDEHYDES AROMATICS BASIC BIOLOGICAL SCIENCES BENZALDEHYDE BENZYL ALCOHOL Benzyl Alcohols Biochemistry Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology CHEMICAL REACTIONS Chemistry Chemistry, Physical and theoretical Electron tunneling electrons ELEMENTS Enzymatic reactions ENZYME ACTIVITY Enzyme kinetics ENZYMES EUMYCOTA Fundamental and applied biological sciences. Psychology FUNGI HEMIACETAL DEHYDROGENASES HYDROGEN Hydrogen isotopes HYDROXY COMPOUNDS ISOTOPE APPLICATIONS ISOTOPE EFFECTS Isotopes Kinetics LABELLED COMPOUNDS Mathematics METABOLISM Methods. Procedures. Technologies MICROORGANISMS Models, Theoretical NONMETALS ORGANIC COMPOUNDS Oxidation Oxidation-Reduction OXIDOREDUCTASES Physical chemistry PLANTS Quantum tunneling REDOX REACTIONS SACCHAROMYCES SACCHAROMYCES CEREVISIAE Saccharomyces cerevisiae - enzymology THERMODYNAMICS TRACER TECHNIQUES Tritium TRITIUM COMPOUNDS Tunneling (Physics) YEASTS
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