Influence of vitamin E treatment on glutathione system after renal ischemia in immature and adult rats
Survival rates were not significantly different 5 days after 20-min unilateral ischemia followed by contralateral nephrectomy: 58 % in 20-day-old vs. 77 % in 55-day-old rats. This experimental approach was used to characterize age dependent differences in the susceptibility of the glutathione system...
Gespeichert in:
| Veröffentlicht in: | Experimental and toxicologic pathology (Print) 1997-02, Vol.49 (1), p.81-86 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 86 |
|---|---|
| container_issue | 1 |
| container_start_page | 81 |
| container_title | Experimental and toxicologic pathology (Print) |
| container_volume | 49 |
| creator | Fleck, Ch Haubold, D. Hillmann, T. Bräunlich, H. |
| description | Survival rates were not significantly different 5 days after 20-min unilateral ischemia followed by contralateral nephrectomy: 58 % in 20-day-old vs. 77 % in 55-day-old rats. This experimental approach was used to characterize age dependent differences in the susceptibility of the glutathione system to ischemia and protective effects of treatment with vitamin E (10 mg/100 g b.wt. once daily s.c.) on the outcome after renal ischemia. The degree of postischemic changes (GSH, γ-GT, TBARS) was the highest on days 1 and 2 after ischemia; at this time, survival rates were similar in young and adult rats. In adult animals, both glutathione content and the activity of γ-GT were significantly reduced after ischemia whereas in immature rats only the glutathione content was distinctly diminished. At the 5th day after ischemia the parameters were almost normalized in the two age groups. Repeated administration of vitamin E improved the survival rate in adult rats up to 100%; in young animals, lethality was not influenced by vitamin E treatment. This reflects the beneficial effects of vitamin E on the glutathione system in adults whereas the vitamin was without effect on the immature rats' glutathione system. |
| doi_str_mv | 10.1016/S0940-2993(97)80072-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78895658</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0940299397800723</els_id><sourcerecordid>78895658</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-996ebe7180004706ac8d2b539c9a5051d88a3b11dbf89065127e110bfd26c4c3</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhi0EKkvhJ1TyASE4BPwRJ_YJVVWBSpU40Ls1scfUKHaK7VTqvyfbXe2V0xzmeT0zjwm54OwzZ3z48ouZnnXCGPnRjJ80Y6Po5Auy4wPXHe-lfEl2J-Q1eVPrH8YEM4qfkTPDtGKa7Ui4yWFeMTukS6CPsUGKmV7TVhBawtzokunveW3Q7uOSkdan2jBRCA0LLZhhprG6e0wR6JaMKUFbC1LInoJf50YLtPqWvAowV3x3rOfk7tv13dWP7vbn95ury9vOSW1aZ8yAE458u4b1IxvAaS8mJY0zoJjiXmuQE-d-CtqwQXExIudsCl4MrnfynHw4PPtQlr8r1mbTthzOM2Rc1mpHrY0alN5AdQBdWWotGOxDiQnKk-XM7vXaZ712786a0T7rtXLLXRwHrFNCf0odfW7998c-VAdzKJBdrCdMDEbIXmzY1wOGm4vHiMVWF_ef4GNB16xf4n8W-QcA7Zc2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78895658</pqid></control><display><type>article</type><title>Influence of vitamin E treatment on glutathione system after renal ischemia in immature and adult rats</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Fleck, Ch ; Haubold, D. ; Hillmann, T. ; Bräunlich, H.</creator><creatorcontrib>Fleck, Ch ; Haubold, D. ; Hillmann, T. ; Bräunlich, H.</creatorcontrib><description>Survival rates were not significantly different 5 days after 20-min unilateral ischemia followed by contralateral nephrectomy: 58 % in 20-day-old vs. 77 % in 55-day-old rats. This experimental approach was used to characterize age dependent differences in the susceptibility of the glutathione system to ischemia and protective effects of treatment with vitamin E (10 mg/100 g b.wt. once daily s.c.) on the outcome after renal ischemia. The degree of postischemic changes (GSH, γ-GT, TBARS) was the highest on days 1 and 2 after ischemia; at this time, survival rates were similar in young and adult rats. In adult animals, both glutathione content and the activity of γ-GT were significantly reduced after ischemia whereas in immature rats only the glutathione content was distinctly diminished. At the 5th day after ischemia the parameters were almost normalized in the two age groups. Repeated administration of vitamin E improved the survival rate in adult rats up to 100%; in young animals, lethality was not influenced by vitamin E treatment. This reflects the beneficial effects of vitamin E on the glutathione system in adults whereas the vitamin was without effect on the immature rats' glutathione system.</description><identifier>ISSN: 0940-2993</identifier><identifier>EISSN: 1618-1433</identifier><identifier>DOI: 10.1016/S0940-2993(97)80072-3</identifier><identifier>PMID: 9085080</identifier><language>eng</language><publisher>Jena: Elsevier GmbH</publisher><subject>Age Factors ; Animals ; Biological and medical sciences ; Female ; gamma-Glutamyltransferase - metabolism ; Glutathione ; Glutathione - metabolism ; Ischemia, renal ; Kidney - blood supply ; Kidney - drug effects ; Kidney - metabolism ; Kidney, age ; Lipid peroxidation ; Lipid Peroxidation - drug effects ; Maturation, rat ; Medical sciences ; Nephrectomy ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Peroxidation, lipid ; Rats ; Rats, Wistar ; Renal ischemia ; Renovascular diseases ; Reperfusion ; Reperfusion Injury - drug therapy ; Reperfusion Injury - metabolism ; Reperfusion Injury - mortality ; Survival Rate ; Thiobarbituric Acid Reactive Substances - metabolism ; Vitamin E ; Vitamin E - pharmacology</subject><ispartof>Experimental and toxicologic pathology (Print), 1997-02, Vol.49 (1), p.81-86</ispartof><rights>1997 Gustav Fischer Verlag</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-996ebe7180004706ac8d2b539c9a5051d88a3b11dbf89065127e110bfd26c4c3</citedby><cites>FETCH-LOGICAL-c389t-996ebe7180004706ac8d2b539c9a5051d88a3b11dbf89065127e110bfd26c4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0940-2993(97)80072-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,23930,23931,25140,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2692342$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9085080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fleck, Ch</creatorcontrib><creatorcontrib>Haubold, D.</creatorcontrib><creatorcontrib>Hillmann, T.</creatorcontrib><creatorcontrib>Bräunlich, H.</creatorcontrib><title>Influence of vitamin E treatment on glutathione system after renal ischemia in immature and adult rats</title><title>Experimental and toxicologic pathology (Print)</title><addtitle>Exp Toxicol Pathol</addtitle><description>Survival rates were not significantly different 5 days after 20-min unilateral ischemia followed by contralateral nephrectomy: 58 % in 20-day-old vs. 77 % in 55-day-old rats. This experimental approach was used to characterize age dependent differences in the susceptibility of the glutathione system to ischemia and protective effects of treatment with vitamin E (10 mg/100 g b.wt. once daily s.c.) on the outcome after renal ischemia. The degree of postischemic changes (GSH, γ-GT, TBARS) was the highest on days 1 and 2 after ischemia; at this time, survival rates were similar in young and adult rats. In adult animals, both glutathione content and the activity of γ-GT were significantly reduced after ischemia whereas in immature rats only the glutathione content was distinctly diminished. At the 5th day after ischemia the parameters were almost normalized in the two age groups. Repeated administration of vitamin E improved the survival rate in adult rats up to 100%; in young animals, lethality was not influenced by vitamin E treatment. This reflects the beneficial effects of vitamin E on the glutathione system in adults whereas the vitamin was without effect on the immature rats' glutathione system.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>gamma-Glutamyltransferase - metabolism</subject><subject>Glutathione</subject><subject>Glutathione - metabolism</subject><subject>Ischemia, renal</subject><subject>Kidney - blood supply</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidney, age</subject><subject>Lipid peroxidation</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Maturation, rat</subject><subject>Medical sciences</subject><subject>Nephrectomy</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Peroxidation, lipid</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Renal ischemia</subject><subject>Renovascular diseases</subject><subject>Reperfusion</subject><subject>Reperfusion Injury - drug therapy</subject><subject>Reperfusion Injury - metabolism</subject><subject>Reperfusion Injury - mortality</subject><subject>Survival Rate</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Vitamin E</subject><subject>Vitamin E - pharmacology</subject><issn>0940-2993</issn><issn>1618-1433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKkvhJ1TyASE4BPwRJ_YJVVWBSpU40Ls1scfUKHaK7VTqvyfbXe2V0xzmeT0zjwm54OwzZ3z48ouZnnXCGPnRjJ80Y6Po5Auy4wPXHe-lfEl2J-Q1eVPrH8YEM4qfkTPDtGKa7Ui4yWFeMTukS6CPsUGKmV7TVhBawtzokunveW3Q7uOSkdan2jBRCA0LLZhhprG6e0wR6JaMKUFbC1LInoJf50YLtPqWvAowV3x3rOfk7tv13dWP7vbn95ury9vOSW1aZ8yAE458u4b1IxvAaS8mJY0zoJjiXmuQE-d-CtqwQXExIudsCl4MrnfynHw4PPtQlr8r1mbTthzOM2Rc1mpHrY0alN5AdQBdWWotGOxDiQnKk-XM7vXaZ712786a0T7rtXLLXRwHrFNCf0odfW7998c-VAdzKJBdrCdMDEbIXmzY1wOGm4vHiMVWF_ef4GNB16xf4n8W-QcA7Zc2</recordid><startdate>19970201</startdate><enddate>19970201</enddate><creator>Fleck, Ch</creator><creator>Haubold, D.</creator><creator>Hillmann, T.</creator><creator>Bräunlich, H.</creator><general>Elsevier GmbH</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970201</creationdate><title>Influence of vitamin E treatment on glutathione system after renal ischemia in immature and adult rats</title><author>Fleck, Ch ; Haubold, D. ; Hillmann, T. ; Bräunlich, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-996ebe7180004706ac8d2b539c9a5051d88a3b11dbf89065127e110bfd26c4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>gamma-Glutamyltransferase - metabolism</topic><topic>Glutathione</topic><topic>Glutathione - metabolism</topic><topic>Ischemia, renal</topic><topic>Kidney - blood supply</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidney, age</topic><topic>Lipid peroxidation</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Maturation, rat</topic><topic>Medical sciences</topic><topic>Nephrectomy</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Peroxidation, lipid</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Renal ischemia</topic><topic>Renovascular diseases</topic><topic>Reperfusion</topic><topic>Reperfusion Injury - drug therapy</topic><topic>Reperfusion Injury - metabolism</topic><topic>Reperfusion Injury - mortality</topic><topic>Survival Rate</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Vitamin E</topic><topic>Vitamin E - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fleck, Ch</creatorcontrib><creatorcontrib>Haubold, D.</creatorcontrib><creatorcontrib>Hillmann, T.</creatorcontrib><creatorcontrib>Bräunlich, H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental and toxicologic pathology (Print)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fleck, Ch</au><au>Haubold, D.</au><au>Hillmann, T.</au><au>Bräunlich, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of vitamin E treatment on glutathione system after renal ischemia in immature and adult rats</atitle><jtitle>Experimental and toxicologic pathology (Print)</jtitle><addtitle>Exp Toxicol Pathol</addtitle><date>1997-02-01</date><risdate>1997</risdate><volume>49</volume><issue>1</issue><spage>81</spage><epage>86</epage><pages>81-86</pages><issn>0940-2993</issn><eissn>1618-1433</eissn><abstract>Survival rates were not significantly different 5 days after 20-min unilateral ischemia followed by contralateral nephrectomy: 58 % in 20-day-old vs. 77 % in 55-day-old rats. This experimental approach was used to characterize age dependent differences in the susceptibility of the glutathione system to ischemia and protective effects of treatment with vitamin E (10 mg/100 g b.wt. once daily s.c.) on the outcome after renal ischemia. The degree of postischemic changes (GSH, γ-GT, TBARS) was the highest on days 1 and 2 after ischemia; at this time, survival rates were similar in young and adult rats. In adult animals, both glutathione content and the activity of γ-GT were significantly reduced after ischemia whereas in immature rats only the glutathione content was distinctly diminished. At the 5th day after ischemia the parameters were almost normalized in the two age groups. Repeated administration of vitamin E improved the survival rate in adult rats up to 100%; in young animals, lethality was not influenced by vitamin E treatment. This reflects the beneficial effects of vitamin E on the glutathione system in adults whereas the vitamin was without effect on the immature rats' glutathione system.</abstract><cop>Jena</cop><pub>Elsevier GmbH</pub><pmid>9085080</pmid><doi>10.1016/S0940-2993(97)80072-3</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0940-2993 |
| ispartof | Experimental and toxicologic pathology (Print), 1997-02, Vol.49 (1), p.81-86 |
| issn | 0940-2993 1618-1433 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78895658 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Age Factors Animals Biological and medical sciences Female gamma-Glutamyltransferase - metabolism Glutathione Glutathione - metabolism Ischemia, renal Kidney - blood supply Kidney - drug effects Kidney - metabolism Kidney, age Lipid peroxidation Lipid Peroxidation - drug effects Maturation, rat Medical sciences Nephrectomy Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Peroxidation, lipid Rats Rats, Wistar Renal ischemia Renovascular diseases Reperfusion Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - mortality Survival Rate Thiobarbituric Acid Reactive Substances - metabolism Vitamin E Vitamin E - pharmacology |
| title | Influence of vitamin E treatment on glutathione system after renal ischemia in immature and adult rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T21%3A53%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20vitamin%20E%20treatment%20on%20glutathione%20system%20after%20renal%20ischemia%20in%20immature%20and%20adult%20rats&rft.jtitle=Experimental%20and%20toxicologic%20pathology%20(Print)&rft.au=Fleck,%20Ch&rft.date=1997-02-01&rft.volume=49&rft.issue=1&rft.spage=81&rft.epage=86&rft.pages=81-86&rft.issn=0940-2993&rft.eissn=1618-1433&rft_id=info:doi/10.1016/S0940-2993(97)80072-3&rft_dat=%3Cproquest_cross%3E78895658%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78895658&rft_id=info:pmid/9085080&rft_els_id=S0940299397800723&rfr_iscdi=true |