The Role of Mn(II)-Peroxidase Activity of Mycobacterial Catalase-Peroxidase in Activation of the Antibiotic Isoniazid

The catalase-peroxidase of Mycobacteria smegmatis exhibits Mn(II)-peroxidase activity characterized by a low K m for Mn(II) (5 μ M ) and a high K m for t -butyl hydroperoxide (100 m M ). This activity, monitored by the formation of Mn(III)-malate or -malonate, is inhibited by Co(II) but not by supe...

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Veröffentlicht in:	The Journal of biological chemistry 1997-04, Vol.272 (14), p.8867-8870
Hauptverfasser:	Magliozzo, R S, Marcinkeviciene, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents - metabolism Bacterial Proteins Isoniazid - metabolism Kinetics Malonates - metabolism Mycobacterium - enzymology Mycobacterium smegmatis Oxidation-Reduction Peroxidases - metabolism Spectrophotometry, Atomic
Online-Zugang:	Volltext
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