Proto-oncogene expression during early myeloid differentiation of normal peripheral blood progenitor cells
Peripheral blood mononuclear cells cultured in liquid medium with fetal calf serum undergo differentiation to myeloblasts (7 days) and then mature granulocytes (14–21 days). This culture system was used to study proto-oncogene expression during pre-myeloblast myeloid differentiation. c- myc mRNA was...
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| Veröffentlicht in: | Leukemia research 1989, Vol.13 (2), p.165,171-169,172 |
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| container_end_page | 169,172 |
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| container_title | Leukemia research |
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| creator | Baer, Maria R. Xue Zhi Gao Sato, Hiroshi Singh, Pradeep Preisler, Harvey D. |
| description | Peripheral blood mononuclear cells cultured in liquid medium with fetal calf serum undergo differentiation to myeloblasts (7 days) and then mature granulocytes (14–21 days). This culture system was used to study proto-oncogene expression during pre-myeloblast myeloid differentiation. c-
myc mRNA was present in the peripheral blood mononuclear cells placed into culture, fell during the first 2–4 days of culture and then rose between days 2–4 and day 7 of culture, prior to and coincident with the appearance of myeloblasts. Histone H3 mRNA was absent or present at very low levels at initiation of cultures, and then rose throughout the first 7 days of culture. c-
fms mRNA was absent at initiation of cultures, and appeared on days 2–5 of culture, prior to the appearance of myeloblasts. c-
fos mRNA was not detected during differentiation of peripheral blood mononuclear cells to myeloblasts. Elucidation of patterns of proto-oncogene expression during normal myeloid differentiation is a prerequisite for interpretation of proto-oncogene expression in myeloid leukemia cells. |
| doi_str_mv | 10.1016/0145-2126(89)90141-0 |
| format | Article |
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myc mRNA was present in the peripheral blood mononuclear cells placed into culture, fell during the first 2–4 days of culture and then rose between days 2–4 and day 7 of culture, prior to and coincident with the appearance of myeloblasts. Histone H3 mRNA was absent or present at very low levels at initiation of cultures, and then rose throughout the first 7 days of culture. c-
fms mRNA was absent at initiation of cultures, and appeared on days 2–5 of culture, prior to the appearance of myeloblasts. c-
fos mRNA was not detected during differentiation of peripheral blood mononuclear cells to myeloblasts. Elucidation of patterns of proto-oncogene expression during normal myeloid differentiation is a prerequisite for interpretation of proto-oncogene expression in myeloid leukemia cells.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/0145-2126(89)90141-0</identifier><identifier>PMID: 2648084</identifier><identifier>CODEN: LEREDD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Blotting, Northern ; Cell Differentiation ; Cell differentiation, maturation, development, hematopoiesis ; Cell physiology ; Cells, Cultured ; differentiation ; Fundamental and applied biological sciences. Psychology ; Granulocytes - physiology ; Hematopoietic Stem Cells - physiology ; Histones - metabolism ; Humans ; Molecular and cellular biology ; myeloid progenitors ; Proto-Oncogene Proteins - metabolism ; Proto-Oncogene Proteins c-myc ; Proto-Oncogenes ; RNA, Messenger - metabolism ; Transcription, Genetic</subject><ispartof>Leukemia research, 1989, Vol.13 (2), p.165,171-169,172</ispartof><rights>1989</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-70017face2d8d929b85fa4167d7ec46ac503413c78556f298c6e188701b8ae583</citedby><cites>FETCH-LOGICAL-c417t-70017face2d8d929b85fa4167d7ec46ac503413c78556f298c6e188701b8ae583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0145-2126(89)90141-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7345029$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2648084$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baer, Maria R.</creatorcontrib><creatorcontrib>Xue Zhi Gao</creatorcontrib><creatorcontrib>Sato, Hiroshi</creatorcontrib><creatorcontrib>Singh, Pradeep</creatorcontrib><creatorcontrib>Preisler, Harvey D.</creatorcontrib><title>Proto-oncogene expression during early myeloid differentiation of normal peripheral blood progenitor cells</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>Peripheral blood mononuclear cells cultured in liquid medium with fetal calf serum undergo differentiation to myeloblasts (7 days) and then mature granulocytes (14–21 days). This culture system was used to study proto-oncogene expression during pre-myeloblast myeloid differentiation. c-
myc mRNA was present in the peripheral blood mononuclear cells placed into culture, fell during the first 2–4 days of culture and then rose between days 2–4 and day 7 of culture, prior to and coincident with the appearance of myeloblasts. Histone H3 mRNA was absent or present at very low levels at initiation of cultures, and then rose throughout the first 7 days of culture. c-
fms mRNA was absent at initiation of cultures, and appeared on days 2–5 of culture, prior to the appearance of myeloblasts. c-
fos mRNA was not detected during differentiation of peripheral blood mononuclear cells to myeloblasts. Elucidation of patterns of proto-oncogene expression during normal myeloid differentiation is a prerequisite for interpretation of proto-oncogene expression in myeloid leukemia cells.</description><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Cell Differentiation</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell physiology</subject><subject>Cells, Cultured</subject><subject>differentiation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Granulocytes - physiology</subject><subject>Hematopoietic Stem Cells - physiology</subject><subject>Histones - metabolism</subject><subject>Humans</subject><subject>Molecular and cellular biology</subject><subject>myeloid progenitors</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-myc</subject><subject>Proto-Oncogenes</subject><subject>RNA, Messenger - metabolism</subject><subject>Transcription, Genetic</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv3CAQhVGUKtmk-QeNxCGq2oNTsMHApVIVNW2lSOmhOSMWhpTIBhe8UfffF2dXe2xOw2i-eXq8QegdJdeU0P4ToYw3LW37D1J9VLWjDTlCKypF13DZ8WO0OiCn6KyUJ0IIV1SdoJO2Z5JItkJPP3OaU5OiTY8QAcPfKUMpIUXsNjnERwwmD1s8bmFIwWEXvIcMcQ5mXqDkcUx5NAOeIIfpN-T6XA8pOTzlRTLMKWMLw1DeojfeDAUu9vUcPdx-_XXzvbm7__bj5stdYxkVcyMIocIbC62TTrVqLbk3jPbCCbCsN5aTjtHOCsl571slbQ9USkHoWhqoHz9H73e61cCfDZRZj6EsDkyEtClaSKkYU6-DlFNVDfQVZDvQ5lRKBq-nHEaTt5oSvdxCL0HrJWgtlX65hSZ17XKvv1mP4A5L-_Dr_Go_N8WawWcTbSgHTHSMk1ZV7PMOgxrac4Csiw0QLbiQwc7apfB_H_8A7qKmlg</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Baer, Maria R.</creator><creator>Xue Zhi Gao</creator><creator>Sato, Hiroshi</creator><creator>Singh, Pradeep</creator><creator>Preisler, Harvey D.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Proto-oncogene expression during early myeloid differentiation of normal peripheral blood progenitor cells</title><author>Baer, Maria R. ; Xue Zhi Gao ; Sato, Hiroshi ; Singh, Pradeep ; Preisler, Harvey D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-70017face2d8d929b85fa4167d7ec46ac503413c78556f298c6e188701b8ae583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Biological and medical sciences</topic><topic>Blotting, Northern</topic><topic>Cell Differentiation</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell physiology</topic><topic>Cells, Cultured</topic><topic>differentiation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Granulocytes - physiology</topic><topic>Hematopoietic Stem Cells - physiology</topic><topic>Histones - metabolism</topic><topic>Humans</topic><topic>Molecular and cellular biology</topic><topic>myeloid progenitors</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Proto-Oncogene Proteins c-myc</topic><topic>Proto-Oncogenes</topic><topic>RNA, Messenger - metabolism</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baer, Maria R.</creatorcontrib><creatorcontrib>Xue Zhi Gao</creatorcontrib><creatorcontrib>Sato, Hiroshi</creatorcontrib><creatorcontrib>Singh, Pradeep</creatorcontrib><creatorcontrib>Preisler, Harvey D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baer, Maria R.</au><au>Xue Zhi Gao</au><au>Sato, Hiroshi</au><au>Singh, Pradeep</au><au>Preisler, Harvey D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proto-oncogene expression during early myeloid differentiation of normal peripheral blood progenitor cells</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>1989</date><risdate>1989</risdate><volume>13</volume><issue>2</issue><spage>165,171</spage><epage>169,172</epage><pages>165,171-169,172</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><coden>LEREDD</coden><abstract>Peripheral blood mononuclear cells cultured in liquid medium with fetal calf serum undergo differentiation to myeloblasts (7 days) and then mature granulocytes (14–21 days). This culture system was used to study proto-oncogene expression during pre-myeloblast myeloid differentiation. c-
myc mRNA was present in the peripheral blood mononuclear cells placed into culture, fell during the first 2–4 days of culture and then rose between days 2–4 and day 7 of culture, prior to and coincident with the appearance of myeloblasts. Histone H3 mRNA was absent or present at very low levels at initiation of cultures, and then rose throughout the first 7 days of culture. c-
fms mRNA was absent at initiation of cultures, and appeared on days 2–5 of culture, prior to the appearance of myeloblasts. c-
fos mRNA was not detected during differentiation of peripheral blood mononuclear cells to myeloblasts. Elucidation of patterns of proto-oncogene expression during normal myeloid differentiation is a prerequisite for interpretation of proto-oncogene expression in myeloid leukemia cells.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>2648084</pmid><doi>10.1016/0145-2126(89)90141-0</doi><tpages>8</tpages></addata></record> |
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| subjects | Biological and medical sciences Blotting, Northern Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell physiology Cells, Cultured differentiation Fundamental and applied biological sciences. Psychology Granulocytes - physiology Hematopoietic Stem Cells - physiology Histones - metabolism Humans Molecular and cellular biology myeloid progenitors Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-myc Proto-Oncogenes RNA, Messenger - metabolism Transcription, Genetic |
| title | Proto-oncogene expression during early myeloid differentiation of normal peripheral blood progenitor cells |
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