Cardiovascular Effects of a Trandolapril/Verapamil Combination in Patients With Mild to Moderate Essential Hypertension

The cardiovascular effects of a combination of trandolapril and verapamil were evaluated in 14 patients with mild to moderate essential hypertension. This combination therapy decreased arterial pressure mainly through a decrease in total peripheral resistance without causing an increase in heart rat...

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Veröffentlicht in:	The American journal of cardiology 1997-03, Vol.79 (6), p.826-828
Hauptverfasser:	Aepfelbacher, Franz C., Messerli, Franz H., Nunez, Eduardo, Michalewicz, Leszek
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angiotensin-Converting Enzyme Inhibitors - therapeutic use Antihypertensive Agents - therapeutic use Antihypertensives Blood pressure Calcium Channel Blockers - therapeutic use Cardiovascular System - drug effects Cardiovascular System - physiopathology Delayed-Action Preparations Demographics Drug dosages Drug therapy Drug Therapy, Combination Enzymes Female Heart Heart rate Humans Hypertension Hypertension - drug therapy Hypertension - physiopathology Indoles - therapeutic use Iodine Male Middle Aged Patients Plasma Stroke Time Factors Verapamil Verapamil - therapeutic use
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Beschreibung
Zusammenfassung:	The cardiovascular effects of a combination of trandolapril and verapamil were evaluated in 14 patients with mild to moderate essential hypertension. This combination therapy decreased arterial pressure mainly through a decrease in total peripheral resistance without causing an increase in heart rate or cardiac output: left ventricular mass was significantly reduced, cardiac systolic function improved, and plasma volume and renal blood flow remained unchanged.
ISSN:	0002-9149 1879-1913
DOI:	10.1016/S0002-9149(96)00883-1