Cell-mediated immune responses to poliovirus: I. Conditions for induction, characterization of effector cells, and cross-reactivity between serotypes for delayed hypersensitivity and T cell proliferative responses
Human polioviruses are categorized into three distinct serotypes (types 1, 2, and 3) based upon their reactivity with specific antibodies. Although a great deal of information has been amassed about the induction and characterization of poliovirus antibody responses, little is known about cell-media...
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| Veröffentlicht in: | Cellular immunology 1989, Vol.119 (2), p.252-262 |
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| creator | Wang, Kegiang Sun, Lizhe Jubelt, Burk Waltenbaugh, Carl |
| description | Human polioviruses are categorized into three distinct serotypes (types 1, 2, and 3) based upon their reactivity with specific antibodies. Although a great deal of information has been amassed about the induction and characterization of poliovirus antibody responses, little is known about cell-mediated immunity to poliovirus and its role in protection. Here, we show that intracutaneous injection of ultraviolet light-inactivated poliovirus into the tailbase of BALB/c mice induces delayed hypersensitivity (DTH) and T-cell proliferative (Tprlf) responses. Both DTH and Tprlf responses to poliovirus are mediated by Ly-1
high2
−, L3T4-bearing T cells. Moreover, known serologic cross-reactivity (i.e., antibody-mediated) of poliovirus serotypes is not predictive of cross-reactivity between the cell-mediated immune responses. |
| doi_str_mv | 10.1016/0008-8749(89)90242-6 |
| format | Article |
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high2
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high2
−, L3T4-bearing T cells. Moreover, known serologic cross-reactivity (i.e., antibody-mediated) of poliovirus serotypes is not predictive of cross-reactivity between the cell-mediated immune responses.</description><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cross Reactions</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Hypersensitivity, Delayed - immunology</subject><subject>Immunobiology</subject><subject>Lymphocyte Activation</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Organs and cells involved in the immune response</subject><subject>Phenotype</subject><subject>poliovirus</subject><subject>Poliovirus - immunology</subject><subject>Serotyping</subject><subject>Species Specificity</subject><subject>T-Lymphocytes - immunology</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt9uFCEUxonR1O3qG2jCjUaTToWBYaAXJmbjnyZNvKnXhIEzKWZmWIHZZn1P30emO2m884rA-XHOB9-H0CtKLimh4gMhRFay5eqdVO8VqXldiSdoQ4kiVU0Fe4o2j8hzdJ7ST0Io5YqcobO6YaoWfIP-7GAYqhGcNxkc9uM4T4AjpH2YEiScA96HwYeDj3O6wteXeBcm57MvZdyHiP3kZrtsL7C9M9HYDNH_NssJDj2GvgebC2fLnHSBzeSwjSGlKkJh_cHnI-4g3wNMOEEM-biHU2cHgzkWTXflJCaYkl_xpcftQ0O8j0VcD7HMO_wj-wV61pshwct13aIfXz7f7r5VN9-_Xu8-3VRQszZXhnLS2fKXlIqWAbHcSlE3wGgDDatF20huoGfEcakIMNFQBk62Hbi-75hiW_T21Lfo-DVDynr0aRFmJghz0q0s9xSX_wVpQyVviitb9HoF5664ovfRjyYe9WpYqb9Z6yZZM_TRTNanR4wqRilTonAfTxyU5x88RJ2sh8kWo2MxRLvgNSV6CZJeUqKXlGip9EOQtGB_AadFv0M</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Wang, Kegiang</creator><creator>Sun, Lizhe</creator><creator>Jubelt, Burk</creator><creator>Waltenbaugh, Carl</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Cell-mediated immune responses to poliovirus: I. Conditions for induction, characterization of effector cells, and cross-reactivity between serotypes for delayed hypersensitivity and T cell proliferative responses</title><author>Wang, Kegiang ; Sun, Lizhe ; Jubelt, Burk ; Waltenbaugh, Carl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e237t-a140bc01611673e0c4c8625e315e53267584aef30d4890e36513ed87bedffb393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cross Reactions</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Hypersensitivity, Delayed - immunology</topic><topic>Immunobiology</topic><topic>Lymphocyte Activation</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Organs and cells involved in the immune response</topic><topic>Phenotype</topic><topic>poliovirus</topic><topic>Poliovirus - immunology</topic><topic>Serotyping</topic><topic>Species Specificity</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Kegiang</creatorcontrib><creatorcontrib>Sun, Lizhe</creatorcontrib><creatorcontrib>Jubelt, Burk</creatorcontrib><creatorcontrib>Waltenbaugh, Carl</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Kegiang</au><au>Sun, Lizhe</au><au>Jubelt, Burk</au><au>Waltenbaugh, Carl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell-mediated immune responses to poliovirus: I. Conditions for induction, characterization of effector cells, and cross-reactivity between serotypes for delayed hypersensitivity and T cell proliferative responses</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>1989</date><risdate>1989</risdate><volume>119</volume><issue>2</issue><spage>252</spage><epage>262</epage><pages>252-262</pages><issn>0008-8749</issn><eissn>1090-2163</eissn><coden>CLIMB8</coden><abstract>Human polioviruses are categorized into three distinct serotypes (types 1, 2, and 3) based upon their reactivity with specific antibodies. Although a great deal of information has been amassed about the induction and characterization of poliovirus antibody responses, little is known about cell-mediated immunity to poliovirus and its role in protection. Here, we show that intracutaneous injection of ultraviolet light-inactivated poliovirus into the tailbase of BALB/c mice induces delayed hypersensitivity (DTH) and T-cell proliferative (Tprlf) responses. Both DTH and Tprlf responses to poliovirus are mediated by Ly-1
high2
−, L3T4-bearing T cells. Moreover, known serologic cross-reactivity (i.e., antibody-mediated) of poliovirus serotypes is not predictive of cross-reactivity between the cell-mediated immune responses.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>2539264</pmid><doi>10.1016/0008-8749(89)90242-6</doi><tpages>11</tpages></addata></record> |
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| ispartof | Cellular immunology, 1989, Vol.119 (2), p.252-262 |
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| language | eng |
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| subjects | Analysis of the immune response. Humoral and cellular immunity Animals Biological and medical sciences Cross Reactions Female Fundamental and applied biological sciences. Psychology Fundamental immunology Hypersensitivity, Delayed - immunology Immunobiology Lymphocyte Activation Mice Mice, Inbred BALB C Mice, Inbred C57BL Organs and cells involved in the immune response Phenotype poliovirus Poliovirus - immunology Serotyping Species Specificity T-Lymphocytes - immunology |
| title | Cell-mediated immune responses to poliovirus: I. Conditions for induction, characterization of effector cells, and cross-reactivity between serotypes for delayed hypersensitivity and T cell proliferative responses |
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