Mycobacterium avium reduces expression of costimulatory/adhesion molecules by human monocytes
Organisms of the Mycobacterium avium complex survive the hostile environment of their host cells, the macrophages, and evade immune response, in part, by interfering with processing and presentation of antigen. We studied the effect of infection with M. avium on the expression of the costimulatory/a...
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Veröffentlicht in: | Cellular immunology 1997-02, Vol.176 (1), p.82-91 |
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creator | Mohagheghpour, N Gammon, D van Vollenhoven, A Hornig, Y Bermudez, L E Young, L S |
description | Organisms of the Mycobacterium avium complex survive the hostile environment of their host cells, the macrophages, and evade immune response, in part, by interfering with processing and presentation of antigen. We studied the effect of infection with M. avium on the expression of the costimulatory/adhesion molecules (referred to herein as accessory molecules) because generating an efficient T cell response requires both the recognition of processed antigen and the participation of accessory molecules. Human peripheral blood monocytes displayed reduced levels of CD54, CD58, and CD86 molecules 1 day after in vitro infection. The reduction in the expression of accessory molecules was not mediated by endogenous IL-10 or prostaglandin because monocytes infected in the presence of either anti-IL-10 neutralizing antibody or indomethacin did not express normal levels of surface CD54, CD58, and CD86 molecules. Consistent with these phenotypic changes, M. avium-infected monocytes were less effective in supporting Ag-independent proliferation of autologous CD4+ T cells. |
doi_str_mv | 10.1006/cimm.1996.1070 |
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We studied the effect of infection with M. avium on the expression of the costimulatory/adhesion molecules (referred to herein as accessory molecules) because generating an efficient T cell response requires both the recognition of processed antigen and the participation of accessory molecules. Human peripheral blood monocytes displayed reduced levels of CD54, CD58, and CD86 molecules 1 day after in vitro infection. The reduction in the expression of accessory molecules was not mediated by endogenous IL-10 or prostaglandin because monocytes infected in the presence of either anti-IL-10 neutralizing antibody or indomethacin did not express normal levels of surface CD54, CD58, and CD86 molecules. Consistent with these phenotypic changes, M. avium-infected monocytes were less effective in supporting Ag-independent proliferation of autologous CD4+ T cells.</description><identifier>ISSN: 0008-8749</identifier><identifier>DOI: 10.1006/cimm.1996.1070</identifier><identifier>PMID: 9070321</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Antigens, CD - biosynthesis ; Cell Adhesion Molecules - biosynthesis ; Cells, Cultured ; Histocompatibility Antigens Class I - biosynthesis ; HLA-DR Antigens - biosynthesis ; Humans ; Lymphocyte Activation ; Monocytes - immunology ; Monocytes - metabolism ; Monocytes - microbiology ; Mycobacterium avium ; Mycobacterium avium - immunology ; Mycobacterium avium - physiology ; T-Lymphocytes - immunology</subject><ispartof>Cellular immunology, 1997-02, Vol.176 (1), p.82-91</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9070321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohagheghpour, N</creatorcontrib><creatorcontrib>Gammon, D</creatorcontrib><creatorcontrib>van Vollenhoven, A</creatorcontrib><creatorcontrib>Hornig, Y</creatorcontrib><creatorcontrib>Bermudez, L E</creatorcontrib><creatorcontrib>Young, L S</creatorcontrib><title>Mycobacterium avium reduces expression of costimulatory/adhesion molecules by human monocytes</title><title>Cellular immunology</title><addtitle>Cell Immunol</addtitle><description>Organisms of the Mycobacterium avium complex survive the hostile environment of their host cells, the macrophages, and evade immune response, in part, by interfering with processing and presentation of antigen. 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Consistent with these phenotypic changes, M. avium-infected monocytes were less effective in supporting Ag-independent proliferation of autologous CD4+ T cells.</description><subject>Antigens, CD - biosynthesis</subject><subject>Cell Adhesion Molecules - biosynthesis</subject><subject>Cells, Cultured</subject><subject>Histocompatibility Antigens Class I - biosynthesis</subject><subject>HLA-DR Antigens - biosynthesis</subject><subject>Humans</subject><subject>Lymphocyte Activation</subject><subject>Monocytes - immunology</subject><subject>Monocytes - metabolism</subject><subject>Monocytes - microbiology</subject><subject>Mycobacterium avium</subject><subject>Mycobacterium avium - immunology</subject><subject>Mycobacterium avium - physiology</subject><subject>T-Lymphocytes - immunology</subject><issn>0008-8749</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1PwzAQxT2ASimsbEiZ2NKeY9eJR1TxJRWxwIgi2zmrQXEd7BiR_54UurPc6d776UnvCLmisKQAYmVa55ZUSjGdJZyQOQBUeVVyeUbOY_wAoJRLmJGZnHxW0Dl5fx6N18oMGNrkMvV1mAGbZDBm-N0HjLH1-8zbzPg4tC51avBhXKlmh7-O8x2a1E24HrNdcuog7b0ZB4wX5NSqLuLlcS_I2_3d6-Yx3748PG1ut3lfsHLI9RoEQylKUVnLBW1wDZwZQS0IydbIOFpkaLmuDKcItLIauUZRGF1MMluQm7_cPvjPhHGoXRsNdp3ao0-xLqtqaizEvyAVAFzIYgKvj2DSDpu6D61TYayPj2M_vfdwgw</recordid><startdate>19970225</startdate><enddate>19970225</enddate><creator>Mohagheghpour, N</creator><creator>Gammon, D</creator><creator>van Vollenhoven, A</creator><creator>Hornig, Y</creator><creator>Bermudez, L E</creator><creator>Young, L S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19970225</creationdate><title>Mycobacterium avium reduces expression of costimulatory/adhesion molecules by human monocytes</title><author>Mohagheghpour, N ; Gammon, D ; van Vollenhoven, A ; Hornig, Y ; Bermudez, L E ; Young, L S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p237t-b5063e96768ff461de5043c61f06935e34efe3ef4b8c41e018fbe4be62cb2ef43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Antigens, CD - biosynthesis</topic><topic>Cell Adhesion Molecules - biosynthesis</topic><topic>Cells, Cultured</topic><topic>Histocompatibility Antigens Class I - biosynthesis</topic><topic>HLA-DR Antigens - biosynthesis</topic><topic>Humans</topic><topic>Lymphocyte Activation</topic><topic>Monocytes - immunology</topic><topic>Monocytes - metabolism</topic><topic>Monocytes - microbiology</topic><topic>Mycobacterium avium</topic><topic>Mycobacterium avium - immunology</topic><topic>Mycobacterium avium - physiology</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohagheghpour, N</creatorcontrib><creatorcontrib>Gammon, D</creatorcontrib><creatorcontrib>van Vollenhoven, A</creatorcontrib><creatorcontrib>Hornig, Y</creatorcontrib><creatorcontrib>Bermudez, L E</creatorcontrib><creatorcontrib>Young, L S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohagheghpour, N</au><au>Gammon, D</au><au>van Vollenhoven, A</au><au>Hornig, Y</au><au>Bermudez, L E</au><au>Young, L S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mycobacterium avium reduces expression of costimulatory/adhesion molecules by human monocytes</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>1997-02-25</date><risdate>1997</risdate><volume>176</volume><issue>1</issue><spage>82</spage><epage>91</epage><pages>82-91</pages><issn>0008-8749</issn><abstract>Organisms of the Mycobacterium avium complex survive the hostile environment of their host cells, the macrophages, and evade immune response, in part, by interfering with processing and presentation of antigen. 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subjects | Antigens, CD - biosynthesis Cell Adhesion Molecules - biosynthesis Cells, Cultured Histocompatibility Antigens Class I - biosynthesis HLA-DR Antigens - biosynthesis Humans Lymphocyte Activation Monocytes - immunology Monocytes - metabolism Monocytes - microbiology Mycobacterium avium Mycobacterium avium - immunology Mycobacterium avium - physiology T-Lymphocytes - immunology |
title | Mycobacterium avium reduces expression of costimulatory/adhesion molecules by human monocytes |
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