INFLUENCE OF AGEING ON CILIARY BEAT FREQUENCY AND ON CILIARY RESPONSE TO LEUKOTRIENE D4 IN GUINEA-PIG TRACHEAL EPITHELIUM
SUMMARY 1. In the present study on guinea‐pig tracheal epithelium, the influence of age on ciliary beat frequency (CBF) was investigated. 2. An age‐dependent decrease in CBF was seen: as the age of the guinea‐pig increased from 0.9 to 16.3 months, CBF decreased from 20.2 to 6.9 Hz. 3. The effect of...
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| Veröffentlicht in: | Clinical and experimental pharmacology & physiology 1997-02, Vol.24 (2), p.166-169 |
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| container_title | Clinical and experimental pharmacology & physiology |
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| creator | Joki, Susanna Saano, Veijo |
| description | SUMMARY
1. In the present study on guinea‐pig tracheal epithelium, the influence of age on ciliary beat frequency (CBF) was investigated.
2. An age‐dependent decrease in CBF was seen: as the age of the guinea‐pig increased from 0.9 to 16.3 months, CBF decreased from 20.2 to 6.9 Hz.
3. The effect of leukotriene D4 (LTD4) on CBF was also examined using tracheal explants from guinea‐pigs of varying ages. The lower CBF of the older animal was increased by LTD4 to a larger extent than was the higher CBF seen in explants taken from younger animals.
4. Ciliary activity and possibly also the sensitivity of the cilia to drugs, seems to be dependent upon the age of the animal, which has to be taken into consideration when comparing the results of different studies on the effects of xenobiotics on mucociliary function. |
| doi_str_mv | 10.1111/j.1440-1681.1997.tb01802.x |
| format | Article |
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1. In the present study on guinea‐pig tracheal epithelium, the influence of age on ciliary beat frequency (CBF) was investigated.
2. An age‐dependent decrease in CBF was seen: as the age of the guinea‐pig increased from 0.9 to 16.3 months, CBF decreased from 20.2 to 6.9 Hz.
3. The effect of leukotriene D4 (LTD4) on CBF was also examined using tracheal explants from guinea‐pigs of varying ages. The lower CBF of the older animal was increased by LTD4 to a larger extent than was the higher CBF seen in explants taken from younger animals.
4. Ciliary activity and possibly also the sensitivity of the cilia to drugs, seems to be dependent upon the age of the animal, which has to be taken into consideration when comparing the results of different studies on the effects of xenobiotics on mucociliary function.</description><identifier>ISSN: 0305-1870</identifier><identifier>EISSN: 1440-1681</identifier><identifier>DOI: 10.1111/j.1440-1681.1997.tb01802.x</identifier><identifier>PMID: 9075591</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>age ; Aging - drug effects ; Aging - physiology ; Animals ; Cilia - drug effects ; Cilia - physiology ; ciliary beat frequency ; Epithelium - drug effects ; Epithelium - physiology ; Guinea Pigs ; guinea-pig ; leukotriene D4 ; Leukotriene D4 - pharmacology ; Male ; Mucociliary Clearance - drug effects ; Trachea - drug effects ; Trachea - physiology</subject><ispartof>Clinical and experimental pharmacology & physiology, 1997-02, Vol.24 (2), p.166-169</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4076-ee85cac3f82f98fcfaf749c352e37533117efefbd6928b50a63a2894836ad5ac3</citedby><cites>FETCH-LOGICAL-c4076-ee85cac3f82f98fcfaf749c352e37533117efefbd6928b50a63a2894836ad5ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1681.1997.tb01802.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1681.1997.tb01802.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9075591$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Joki, Susanna</creatorcontrib><creatorcontrib>Saano, Veijo</creatorcontrib><title>INFLUENCE OF AGEING ON CILIARY BEAT FREQUENCY AND ON CILIARY RESPONSE TO LEUKOTRIENE D4 IN GUINEA-PIG TRACHEAL EPITHELIUM</title><title>Clinical and experimental pharmacology & physiology</title><addtitle>Clin Exp Pharmacol Physiol</addtitle><description>SUMMARY
1. In the present study on guinea‐pig tracheal epithelium, the influence of age on ciliary beat frequency (CBF) was investigated.
2. An age‐dependent decrease in CBF was seen: as the age of the guinea‐pig increased from 0.9 to 16.3 months, CBF decreased from 20.2 to 6.9 Hz.
3. The effect of leukotriene D4 (LTD4) on CBF was also examined using tracheal explants from guinea‐pigs of varying ages. The lower CBF of the older animal was increased by LTD4 to a larger extent than was the higher CBF seen in explants taken from younger animals.
4. Ciliary activity and possibly also the sensitivity of the cilia to drugs, seems to be dependent upon the age of the animal, which has to be taken into consideration when comparing the results of different studies on the effects of xenobiotics on mucociliary function.</description><subject>age</subject><subject>Aging - drug effects</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Cilia - drug effects</subject><subject>Cilia - physiology</subject><subject>ciliary beat frequency</subject><subject>Epithelium - drug effects</subject><subject>Epithelium - physiology</subject><subject>Guinea Pigs</subject><subject>guinea-pig</subject><subject>leukotriene D4</subject><subject>Leukotriene D4 - pharmacology</subject><subject>Male</subject><subject>Mucociliary Clearance - drug effects</subject><subject>Trachea - drug effects</subject><subject>Trachea - physiology</subject><issn>0305-1870</issn><issn>1440-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE9r2zAchkVZ6bK2H2EgdtjNnmRZf7zDwHUUR8yTU9fe6Ek4jgzJkqazEpZ8-9okhF2ny-_wvu8jeAD4hJGP-_dl5eMwRB5mAvs4iri_myMsUOAfrsDoEr0DI0QQ9bDg6D344NwKIUQRIzfgJkKc0giPwFHpSVZJnUiYT2CcSqVTmGuYqEzFxTN8kHEJJ4V8HDrPMNbjf9NCPs1y_SRhmcNMVt_zslBSSzgOodIwrZSWsTdTKSyLOJnKOINypsqpzFT14w5ct_Xa2fvzvQXVRJbJ1MvyVCVx5jUh4syzVtCmbkgrgjYSbdPWLQ-jhtDAEk4JwZjb1rbzBYsCMaeoZqQORBQKwuoF7Ye34POJ-9pt_-yt25nN0jV2va5f7HbvDBciQpijvvj1VGy6rXOdbc1rt9zU3dFgZAbvZmUGuWaQawbv5uzdHPrxx_Mv-_nGLi7Ts-g-_3bK_y7X9vgfZJPIGWasB3gnwNLt7OECqLvfhvHehPmlUxNkP8ciyR7MmLwB6ayXYA</recordid><startdate>199702</startdate><enddate>199702</enddate><creator>Joki, Susanna</creator><creator>Saano, Veijo</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199702</creationdate><title>INFLUENCE OF AGEING ON CILIARY BEAT FREQUENCY AND ON CILIARY RESPONSE TO LEUKOTRIENE D4 IN GUINEA-PIG TRACHEAL EPITHELIUM</title><author>Joki, Susanna ; Saano, Veijo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4076-ee85cac3f82f98fcfaf749c352e37533117efefbd6928b50a63a2894836ad5ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>age</topic><topic>Aging - drug effects</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Cilia - drug effects</topic><topic>Cilia - physiology</topic><topic>ciliary beat frequency</topic><topic>Epithelium - drug effects</topic><topic>Epithelium - physiology</topic><topic>Guinea Pigs</topic><topic>guinea-pig</topic><topic>leukotriene D4</topic><topic>Leukotriene D4 - pharmacology</topic><topic>Male</topic><topic>Mucociliary Clearance - drug effects</topic><topic>Trachea - drug effects</topic><topic>Trachea - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joki, Susanna</creatorcontrib><creatorcontrib>Saano, Veijo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental pharmacology & physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joki, Susanna</au><au>Saano, Veijo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>INFLUENCE OF AGEING ON CILIARY BEAT FREQUENCY AND ON CILIARY RESPONSE TO LEUKOTRIENE D4 IN GUINEA-PIG TRACHEAL EPITHELIUM</atitle><jtitle>Clinical and experimental pharmacology & physiology</jtitle><addtitle>Clin Exp Pharmacol Physiol</addtitle><date>1997-02</date><risdate>1997</risdate><volume>24</volume><issue>2</issue><spage>166</spage><epage>169</epage><pages>166-169</pages><issn>0305-1870</issn><eissn>1440-1681</eissn><abstract>SUMMARY
1. In the present study on guinea‐pig tracheal epithelium, the influence of age on ciliary beat frequency (CBF) was investigated.
2. An age‐dependent decrease in CBF was seen: as the age of the guinea‐pig increased from 0.9 to 16.3 months, CBF decreased from 20.2 to 6.9 Hz.
3. The effect of leukotriene D4 (LTD4) on CBF was also examined using tracheal explants from guinea‐pigs of varying ages. The lower CBF of the older animal was increased by LTD4 to a larger extent than was the higher CBF seen in explants taken from younger animals.
4. Ciliary activity and possibly also the sensitivity of the cilia to drugs, seems to be dependent upon the age of the animal, which has to be taken into consideration when comparing the results of different studies on the effects of xenobiotics on mucociliary function.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9075591</pmid><doi>10.1111/j.1440-1681.1997.tb01802.x</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0305-1870 |
| ispartof | Clinical and experimental pharmacology & physiology, 1997-02, Vol.24 (2), p.166-169 |
| issn | 0305-1870 1440-1681 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | age Aging - drug effects Aging - physiology Animals Cilia - drug effects Cilia - physiology ciliary beat frequency Epithelium - drug effects Epithelium - physiology Guinea Pigs guinea-pig leukotriene D4 Leukotriene D4 - pharmacology Male Mucociliary Clearance - drug effects Trachea - drug effects Trachea - physiology |
| title | INFLUENCE OF AGEING ON CILIARY BEAT FREQUENCY AND ON CILIARY RESPONSE TO LEUKOTRIENE D4 IN GUINEA-PIG TRACHEAL EPITHELIUM |
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