Peroxidase Substrates Stimulate the Oxidation of Hydralazine to Metabolites Which Cause Single-Strand Breaks in DNA

Hydrazines are believed to be oxidized by peroxidases to reactive intermediates responsible for a variety of adverse side effects including cancer and drug-induced lupus. However, hydrazines are regarded as a poor peroxidase substrates because inactivation of the peroxidase occurs during oxidation o...

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Veröffentlicht in:	Chemical research in toxicology 1997-03, Vol.10 (3), p.328-334
Hauptverfasser:	Reilly, Christopher A, Aust, Steven D
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA Damage DNA, Single-Stranded - chemistry Electron Spin Resonance Spectroscopy Free Radicals Horseradish Peroxidase Hydralazine - metabolism Hydrogen-Ion Concentration Oxidation-Reduction Peroxidases - metabolism Spectrophotometry, Ultraviolet
Online-Zugang:	Volltext
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