Effects of acute administration of d-amphetamine and haloperidol on procedural learning in man
The effects of an indirect dopamine-agonist, d-amphetamine, and a non-selective dopamine receptor antagonist, haloperidol, were investigated in normal male volunteers using a between-subjects double-blind design in a procedural learning task, thought mainly to involve unconscious/automatic learning....
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| Veröffentlicht in: | Psychopharmacologia 1997-02, Vol.129 (3), p.271-276 |
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| container_title | Psychopharmacologia |
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| creator | KUMARI, V CORR, P. J MULLIGAN, O. F COTTER, P. A CHECKLEY, S. A GRAY, J. A |
| description | The effects of an indirect dopamine-agonist, d-amphetamine, and a non-selective dopamine receptor antagonist, haloperidol, were investigated in normal male volunteers using a between-subjects double-blind design in a procedural learning task, thought mainly to involve unconscious/automatic learning. The results showed: (1) d-amphetamine facilitated response speed, whereas haloperidol inhibited it, in comparison to placebo; (2) the linear increase in procedural learning corresponded with pharmacological manipulation of degree of dopaminergic activity, i.e. subjects given haloperidol showed the least, and subjects given d-amphetamine the greatest, procedural learning. The implications of these findings are discussed in relation to investigation of abnormalities of procedural learning processes in schizophrenia. |
| doi_str_mv | 10.1007/s002130050190 |
| format | Article |
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| subjects | Adolescent Adult Amphetamines Antipsychotics Between-subjects design Biological and medical sciences Blindness Dextroamphetamine - pharmacology Dopamine Agonists - pharmacology Dopamine Antagonists - pharmacology Dopamine receptors Drug toxicity and drugs side effects treatment Haloperidol Haloperidol - pharmacology Humans Learning Learning - drug effects Male Medical sciences Mental disorders Middle Aged Pharmacology. Drug treatments Schizophrenia Toxicity: nervous system and muscle |
| title | Effects of acute administration of d-amphetamine and haloperidol on procedural learning in man |
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