The effect of transdermal estradiol on the conjunctiva in postmenopausal women
Objective: To evaluate the effect of hormonal replacement therapy on the conjunctiva in postmenopausal women. Study design: A prospective clinical study in the setting of a tertiary-care university hospital. Eleven postmenopausal women received hormonal replacement therapy (transdermal estradiol or...
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| Veröffentlicht in: | European journal of obstetrics & gynecology and reproductive biology 1997-03, Vol.72 (1), p.93-96 |
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| container_title | European journal of obstetrics & gynecology and reproductive biology |
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| creator | Vavilis, Dimitrios Agorastos, Theodoros Vakiani, Mahi Jafetas, John Panidis, Dimitrios Konstantinidis, Theodoros Bontis, John |
| description | Objective: To evaluate the effect of hormonal replacement therapy on the conjunctiva in postmenopausal women.
Study design: A prospective clinical study in the setting of a tertiary-care university hospital. Eleven postmenopausal women received hormonal replacement therapy (transdermal estradiol or transdermal estradiol plus medroxyprogesterone acetate) for 4 months. Serum estradiol levels as well as vaginal and conjunctival maturation value (a cytological parameter) were measured before and after the treatment. Data were analysed using the Wilcoxon matched pairs signed-Rank test.
Results: A significant increase of serum estradiol levels (
P < 0.01) and of vaginal maturation value (
P < 0.01) were found. Cytological maturation changes in conjunctival epithelium were also observed. These changes, although mild, were statistically significant (
P < 0.01).
Conclusion: These data support the view that the hormonal replacement therapy induces cytological maturation changes in conjunctival epithelium in postmenopausal women. |
| doi_str_mv | 10.1016/S0301-2115(97)85911-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78886731</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0301211597859118</els_id><sourcerecordid>78886731</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-6e84d59f56d7aa85931f2c671a6e96578e336129995304dca000e5b18150b79f3</originalsourceid><addsrcrecordid>eNqFkE1LAzEQhoMoWqs_obAHET2sJpvm6yRS_ALRg3oOaXaCKbubmuxW_PemtvTqXMIwz0xeHoQmBF8RTPj1G6aYlBUh7EKJS8kUIaXcQyMiRVUKzqb7aLRDjtBxSguci1J1iA4VFnxaqRF6ef-EApwD2xfBFX00XaohtqYpIOWu9qEpQlf0GbOhWwyd7f3KFL4rliH1LXRhaYaU8e-QmxN04EyT4HT7jtHH_d377LF8fn14mt0-l5ZK1Zcc5LRmyjFeC2NydkpcZbkghoPiTEiglJNKKcUontbW5ODA5kQShudCOTpG55u7yxi-hpxUtz5ZaBrTQRiSFlJKLijJINuANoaUIji9jL418UcTrNce9Z9HvZakldB_HrXMe5PtB8O8hXq3tRWX52fbuUnWNC57sz7tsIophsUau9lgkGWsPESdrIfOQu1jVq7r4P8J8gstuo5e</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78886731</pqid></control><display><type>article</type><title>The effect of transdermal estradiol on the conjunctiva in postmenopausal women</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Vavilis, Dimitrios ; Agorastos, Theodoros ; Vakiani, Mahi ; Jafetas, John ; Panidis, Dimitrios ; Konstantinidis, Theodoros ; Bontis, John</creator><creatorcontrib>Vavilis, Dimitrios ; Agorastos, Theodoros ; Vakiani, Mahi ; Jafetas, John ; Panidis, Dimitrios ; Konstantinidis, Theodoros ; Bontis, John</creatorcontrib><description>Objective: To evaluate the effect of hormonal replacement therapy on the conjunctiva in postmenopausal women.
Study design: A prospective clinical study in the setting of a tertiary-care university hospital. Eleven postmenopausal women received hormonal replacement therapy (transdermal estradiol or transdermal estradiol plus medroxyprogesterone acetate) for 4 months. Serum estradiol levels as well as vaginal and conjunctival maturation value (a cytological parameter) were measured before and after the treatment. Data were analysed using the Wilcoxon matched pairs signed-Rank test.
Results: A significant increase of serum estradiol levels (
P < 0.01) and of vaginal maturation value (
P < 0.01) were found. Cytological maturation changes in conjunctival epithelium were also observed. These changes, although mild, were statistically significant (
P < 0.01).
Conclusion: These data support the view that the hormonal replacement therapy induces cytological maturation changes in conjunctival epithelium in postmenopausal women.</description><identifier>ISSN: 0301-2115</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/S0301-2115(97)85911-8</identifier><identifier>PMID: 9076429</identifier><identifier>CODEN: EOGRAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Administration, Cutaneous ; Adult ; Biological and medical sciences ; Conjunctiva - cytology ; Conjunctiva - drug effects ; Conjunctival cytology ; Epithelial Cells ; Epithelium - drug effects ; Estradiol - administration & dosage ; Estradiol - blood ; Estradiol - therapeutic use ; Female ; Hormonal replacement therapy ; Hormones. Endocrine system ; Humans ; Maturation value ; Medical sciences ; Medroxyprogesterone Acetate - administration & dosage ; Medroxyprogesterone Acetate - therapeutic use ; Middle Aged ; Pharmacology. Drug treatments ; Postmenopause ; Vaginal cytology ; Vaginal Smears</subject><ispartof>European journal of obstetrics & gynecology and reproductive biology, 1997-03, Vol.72 (1), p.93-96</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-6e84d59f56d7aa85931f2c671a6e96578e336129995304dca000e5b18150b79f3</citedby><cites>FETCH-LOGICAL-c389t-6e84d59f56d7aa85931f2c671a6e96578e336129995304dca000e5b18150b79f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0301-2115(97)85911-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2595079$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9076429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vavilis, Dimitrios</creatorcontrib><creatorcontrib>Agorastos, Theodoros</creatorcontrib><creatorcontrib>Vakiani, Mahi</creatorcontrib><creatorcontrib>Jafetas, John</creatorcontrib><creatorcontrib>Panidis, Dimitrios</creatorcontrib><creatorcontrib>Konstantinidis, Theodoros</creatorcontrib><creatorcontrib>Bontis, John</creatorcontrib><title>The effect of transdermal estradiol on the conjunctiva in postmenopausal women</title><title>European journal of obstetrics & gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description>Objective: To evaluate the effect of hormonal replacement therapy on the conjunctiva in postmenopausal women.
Study design: A prospective clinical study in the setting of a tertiary-care university hospital. Eleven postmenopausal women received hormonal replacement therapy (transdermal estradiol or transdermal estradiol plus medroxyprogesterone acetate) for 4 months. Serum estradiol levels as well as vaginal and conjunctival maturation value (a cytological parameter) were measured before and after the treatment. Data were analysed using the Wilcoxon matched pairs signed-Rank test.
Results: A significant increase of serum estradiol levels (
P < 0.01) and of vaginal maturation value (
P < 0.01) were found. Cytological maturation changes in conjunctival epithelium were also observed. These changes, although mild, were statistically significant (
P < 0.01).
Conclusion: These data support the view that the hormonal replacement therapy induces cytological maturation changes in conjunctival epithelium in postmenopausal women.</description><subject>Administration, Cutaneous</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Conjunctiva - cytology</subject><subject>Conjunctiva - drug effects</subject><subject>Conjunctival cytology</subject><subject>Epithelial Cells</subject><subject>Epithelium - drug effects</subject><subject>Estradiol - administration & dosage</subject><subject>Estradiol - blood</subject><subject>Estradiol - therapeutic use</subject><subject>Female</subject><subject>Hormonal replacement therapy</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Maturation value</subject><subject>Medical sciences</subject><subject>Medroxyprogesterone Acetate - administration & dosage</subject><subject>Medroxyprogesterone Acetate - therapeutic use</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Postmenopause</subject><subject>Vaginal cytology</subject><subject>Vaginal Smears</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMoWqs_obAHET2sJpvm6yRS_ALRg3oOaXaCKbubmuxW_PemtvTqXMIwz0xeHoQmBF8RTPj1G6aYlBUh7EKJS8kUIaXcQyMiRVUKzqb7aLRDjtBxSguci1J1iA4VFnxaqRF6ef-EApwD2xfBFX00XaohtqYpIOWu9qEpQlf0GbOhWwyd7f3KFL4rliH1LXRhaYaU8e-QmxN04EyT4HT7jtHH_d377LF8fn14mt0-l5ZK1Zcc5LRmyjFeC2NydkpcZbkghoPiTEiglJNKKcUontbW5ODA5kQShudCOTpG55u7yxi-hpxUtz5ZaBrTQRiSFlJKLijJINuANoaUIji9jL418UcTrNce9Z9HvZakldB_HrXMe5PtB8O8hXq3tRWX52fbuUnWNC57sz7tsIophsUau9lgkGWsPESdrIfOQu1jVq7r4P8J8gstuo5e</recordid><startdate>19970301</startdate><enddate>19970301</enddate><creator>Vavilis, Dimitrios</creator><creator>Agorastos, Theodoros</creator><creator>Vakiani, Mahi</creator><creator>Jafetas, John</creator><creator>Panidis, Dimitrios</creator><creator>Konstantinidis, Theodoros</creator><creator>Bontis, John</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970301</creationdate><title>The effect of transdermal estradiol on the conjunctiva in postmenopausal women</title><author>Vavilis, Dimitrios ; Agorastos, Theodoros ; Vakiani, Mahi ; Jafetas, John ; Panidis, Dimitrios ; Konstantinidis, Theodoros ; Bontis, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-6e84d59f56d7aa85931f2c671a6e96578e336129995304dca000e5b18150b79f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Administration, Cutaneous</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Conjunctiva - cytology</topic><topic>Conjunctiva - drug effects</topic><topic>Conjunctival cytology</topic><topic>Epithelial Cells</topic><topic>Epithelium - drug effects</topic><topic>Estradiol - administration & dosage</topic><topic>Estradiol - blood</topic><topic>Estradiol - therapeutic use</topic><topic>Female</topic><topic>Hormonal replacement therapy</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Maturation value</topic><topic>Medical sciences</topic><topic>Medroxyprogesterone Acetate - administration & dosage</topic><topic>Medroxyprogesterone Acetate - therapeutic use</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Postmenopause</topic><topic>Vaginal cytology</topic><topic>Vaginal Smears</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vavilis, Dimitrios</creatorcontrib><creatorcontrib>Agorastos, Theodoros</creatorcontrib><creatorcontrib>Vakiani, Mahi</creatorcontrib><creatorcontrib>Jafetas, John</creatorcontrib><creatorcontrib>Panidis, Dimitrios</creatorcontrib><creatorcontrib>Konstantinidis, Theodoros</creatorcontrib><creatorcontrib>Bontis, John</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vavilis, Dimitrios</au><au>Agorastos, Theodoros</au><au>Vakiani, Mahi</au><au>Jafetas, John</au><au>Panidis, Dimitrios</au><au>Konstantinidis, Theodoros</au><au>Bontis, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of transdermal estradiol on the conjunctiva in postmenopausal women</atitle><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>1997-03-01</date><risdate>1997</risdate><volume>72</volume><issue>1</issue><spage>93</spage><epage>96</epage><pages>93-96</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><coden>EOGRAL</coden><abstract>Objective: To evaluate the effect of hormonal replacement therapy on the conjunctiva in postmenopausal women.
Study design: A prospective clinical study in the setting of a tertiary-care university hospital. Eleven postmenopausal women received hormonal replacement therapy (transdermal estradiol or transdermal estradiol plus medroxyprogesterone acetate) for 4 months. Serum estradiol levels as well as vaginal and conjunctival maturation value (a cytological parameter) were measured before and after the treatment. Data were analysed using the Wilcoxon matched pairs signed-Rank test.
Results: A significant increase of serum estradiol levels (
P < 0.01) and of vaginal maturation value (
P < 0.01) were found. Cytological maturation changes in conjunctival epithelium were also observed. These changes, although mild, were statistically significant (
P < 0.01).
Conclusion: These data support the view that the hormonal replacement therapy induces cytological maturation changes in conjunctival epithelium in postmenopausal women.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>9076429</pmid><doi>10.1016/S0301-2115(97)85911-8</doi><tpages>4</tpages></addata></record> |
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| ispartof | European journal of obstetrics & gynecology and reproductive biology, 1997-03, Vol.72 (1), p.93-96 |
| issn | 0301-2115 1872-7654 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Administration, Cutaneous Adult Biological and medical sciences Conjunctiva - cytology Conjunctiva - drug effects Conjunctival cytology Epithelial Cells Epithelium - drug effects Estradiol - administration & dosage Estradiol - blood Estradiol - therapeutic use Female Hormonal replacement therapy Hormones. Endocrine system Humans Maturation value Medical sciences Medroxyprogesterone Acetate - administration & dosage Medroxyprogesterone Acetate - therapeutic use Middle Aged Pharmacology. Drug treatments Postmenopause Vaginal cytology Vaginal Smears |
| title | The effect of transdermal estradiol on the conjunctiva in postmenopausal women |
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