Normalization by dietary cod-liver oil of reduced thrombogenesis in essential fatty acid deficient rats
Rats, deficient in essential fatty acids (EFA), were given diets containing 5 energy% sunflowerseed oil (SO, rich in linoleic acid), cod-liver oil (CLO, rich in timnodonic acid and cervonic acid), or hydrogenated coconut oil (HCO), containing no EFAs at all. SO and CLO feeding resulted in normalizat...
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| Veröffentlicht in: | Thrombosis research 1989, Vol.53 (1), p.45-53 |
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| creator | Hornstra, G. Haddeman, E. Don, J.A. |
| description | Rats, deficient in essential fatty acids (EFA), were given diets containing 5 energy% sunflowerseed oil (SO, rich in linoleic acid), cod-liver oil (CLO, rich in timnodonic acid and cervonic acid), or hydrogenated coconut oil (HCO), containing no EFAs at all. SO and CLO feeding resulted in normalization of the reduced arterial thrombus formation in EFA-deficient animals. SO feeding was associated with the normalization of the arachidonic acid content of platelet phospholipids. CLO feeding did not have this effect but greatly increased the availability of timnodonic acid (EPA) and cervonic acid (DHA). Further reseach is required to investigate whether these changes in fatty acid composition can be hold responsible for the normalizing effect of dietary CLO on the disturbed arterial thrombosis tendency in EFA deficient rats, possibly via the formation of eicosanoids. |
| doi_str_mv | 10.1016/0049-3848(89)90114-X |
| format | Article |
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SO and CLO feeding resulted in normalization of the reduced arterial thrombus formation in EFA-deficient animals. SO feeding was associated with the normalization of the arachidonic acid content of platelet phospholipids. CLO feeding did not have this effect but greatly increased the availability of timnodonic acid (EPA) and cervonic acid (DHA). Further reseach is required to investigate whether these changes in fatty acid composition can be hold responsible for the normalizing effect of dietary CLO on the disturbed arterial thrombosis tendency in EFA deficient rats, possibly via the formation of eicosanoids.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/0049-3848(89)90114-X</identifier><identifier>PMID: 2922701</identifier><identifier>CODEN: THBRAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Ltd</publisher><subject>Animals ; Arterial thrombosis ; Biological and medical sciences ; blood platelet ; Coconut Oil ; Cod Liver Oil - administration & dosage ; Cod Liver Oil - therapeutic use ; Dietary Fats - therapeutic use ; Dietary Fats, Unsaturated - administration & dosage ; Disorders of blood lipids. Hyperlipoproteinemia ; essential fatty acid deficiency ; fatty acid ; Fatty Acids, Essential - deficiency ; Fish Oils - therapeutic use ; Male ; Medical sciences ; Metabolic diseases ; phospholipid ; Plant Oils - therapeutic use ; rat ; Rats ; Rats, Inbred Strains ; Sunflower Oil ; Thrombosis - drug therapy</subject><ispartof>Thrombosis research, 1989, Vol.53 (1), p.45-53</ispartof><rights>1989</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c335t-ea3f470fcd499b2881e10b83d7ec0d88f888455bc04a8e2f927db15dffd18123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0049-3848(89)90114-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7232857$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2922701$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hornstra, G.</creatorcontrib><creatorcontrib>Haddeman, E.</creatorcontrib><creatorcontrib>Don, J.A.</creatorcontrib><title>Normalization by dietary cod-liver oil of reduced thrombogenesis in essential fatty acid deficient rats</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>Rats, deficient in essential fatty acids (EFA), were given diets containing 5 energy% sunflowerseed oil (SO, rich in linoleic acid), cod-liver oil (CLO, rich in timnodonic acid and cervonic acid), or hydrogenated coconut oil (HCO), containing no EFAs at all. SO and CLO feeding resulted in normalization of the reduced arterial thrombus formation in EFA-deficient animals. SO feeding was associated with the normalization of the arachidonic acid content of platelet phospholipids. CLO feeding did not have this effect but greatly increased the availability of timnodonic acid (EPA) and cervonic acid (DHA). Further reseach is required to investigate whether these changes in fatty acid composition can be hold responsible for the normalizing effect of dietary CLO on the disturbed arterial thrombosis tendency in EFA deficient rats, possibly via the formation of eicosanoids.</description><subject>Animals</subject><subject>Arterial thrombosis</subject><subject>Biological and medical sciences</subject><subject>blood platelet</subject><subject>Coconut Oil</subject><subject>Cod Liver Oil - administration & dosage</subject><subject>Cod Liver Oil - therapeutic use</subject><subject>Dietary Fats - therapeutic use</subject><subject>Dietary Fats, Unsaturated - administration & dosage</subject><subject>Disorders of blood lipids. Hyperlipoproteinemia</subject><subject>essential fatty acid deficiency</subject><subject>fatty acid</subject><subject>Fatty Acids, Essential - deficiency</subject><subject>Fish Oils - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>phospholipid</subject><subject>Plant Oils - therapeutic use</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Sunflower Oil</subject><subject>Thrombosis - drug therapy</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFrFTEQx4Mo9bX6DRRyENHD1iSbNclFkGJVKO2lh95CNpnUkd1NTfIKr5_erO_xjp4GZn7_YeZHyBvOzjnjnz8xJk3Xa6k_aPPRMM5ld_eMbLhWphNSiedkc0RektNSfjPGFTfDCTkRRgjF-IbcX6c8uwmfXMW00HFHA0J1eUd9Ct2Ej5BpwommSDOErYdA66-c5jHdwwIFC8WFQimwVHQTja7WHXUeAw0Q0WPr0-xqeUVeRDcVeH2oZ-T28tvtxY_u6ub7z4uvV53v-6F24PooFYs-SGNGoTUHzkbdBwWeBa2j1loOw-iZdBpENEKFkQ8hxsA1F_0Zeb9f-5DTny2UamcsHqbJLZC2xao1355voNyDPqdSMkT7kHFuf1vO7KrXru7s6s5qY__ptXct9vawfzvOEI6hg882f3eYu-LdFLNbPJYjpkQv9KAa9mWPQVPxiJBtWVU1u5jBVxsS_v-Ov8YomEc</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Hornstra, G.</creator><creator>Haddeman, E.</creator><creator>Don, J.A.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Normalization by dietary cod-liver oil of reduced thrombogenesis in essential fatty acid deficient rats</title><author>Hornstra, G. ; Haddeman, E. ; Don, J.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-ea3f470fcd499b2881e10b83d7ec0d88f888455bc04a8e2f927db15dffd18123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Arterial thrombosis</topic><topic>Biological and medical sciences</topic><topic>blood platelet</topic><topic>Coconut Oil</topic><topic>Cod Liver Oil - administration & dosage</topic><topic>Cod Liver Oil - therapeutic use</topic><topic>Dietary Fats - therapeutic use</topic><topic>Dietary Fats, Unsaturated - administration & dosage</topic><topic>Disorders of blood lipids. Hyperlipoproteinemia</topic><topic>essential fatty acid deficiency</topic><topic>fatty acid</topic><topic>Fatty Acids, Essential - deficiency</topic><topic>Fish Oils - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>phospholipid</topic><topic>Plant Oils - therapeutic use</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Sunflower Oil</topic><topic>Thrombosis - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hornstra, G.</creatorcontrib><creatorcontrib>Haddeman, E.</creatorcontrib><creatorcontrib>Don, J.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hornstra, G.</au><au>Haddeman, E.</au><au>Don, J.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normalization by dietary cod-liver oil of reduced thrombogenesis in essential fatty acid deficient rats</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>1989</date><risdate>1989</risdate><volume>53</volume><issue>1</issue><spage>45</spage><epage>53</epage><pages>45-53</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><coden>THBRAA</coden><abstract>Rats, deficient in essential fatty acids (EFA), were given diets containing 5 energy% sunflowerseed oil (SO, rich in linoleic acid), cod-liver oil (CLO, rich in timnodonic acid and cervonic acid), or hydrogenated coconut oil (HCO), containing no EFAs at all. SO and CLO feeding resulted in normalization of the reduced arterial thrombus formation in EFA-deficient animals. SO feeding was associated with the normalization of the arachidonic acid content of platelet phospholipids. CLO feeding did not have this effect but greatly increased the availability of timnodonic acid (EPA) and cervonic acid (DHA). Further reseach is required to investigate whether these changes in fatty acid composition can be hold responsible for the normalizing effect of dietary CLO on the disturbed arterial thrombosis tendency in EFA deficient rats, possibly via the formation of eicosanoids.</abstract><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>2922701</pmid><doi>10.1016/0049-3848(89)90114-X</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0049-3848 |
| ispartof | Thrombosis research, 1989, Vol.53 (1), p.45-53 |
| issn | 0049-3848 1879-2472 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Arterial thrombosis Biological and medical sciences blood platelet Coconut Oil Cod Liver Oil - administration & dosage Cod Liver Oil - therapeutic use Dietary Fats - therapeutic use Dietary Fats, Unsaturated - administration & dosage Disorders of blood lipids. Hyperlipoproteinemia essential fatty acid deficiency fatty acid Fatty Acids, Essential - deficiency Fish Oils - therapeutic use Male Medical sciences Metabolic diseases phospholipid Plant Oils - therapeutic use rat Rats Rats, Inbred Strains Sunflower Oil Thrombosis - drug therapy |
| title | Normalization by dietary cod-liver oil of reduced thrombogenesis in essential fatty acid deficient rats |
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