Tazobactam is a potent inactivator of selected inhibitor-resistant class A β-lactamases

The β-lactam β-lactamase inhibitor combinations (ampicillin/clavulanate, ampicillin/sulbactam, ticarcillin/clavulanate and piperacillin/tazobactam) were tested against selected inhibitor-resistant class A β-lactamases of the TEM and OHIO-1 varieties. Minimum inhibitor concentrations (MIC) revealed t...

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Veröffentlicht in:	FEMS microbiology letters 1997-03, Vol.148 (1), p.59-62
Hauptverfasser:	Bonomo, R.A, Rudin, S.A, Shlaes, D.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Ampicillin - pharmacology Ampicillin Resistance - physiology Anti-Bacterial Agents - pharmacology beta-Lactamase Inhibitors Clavulanic Acid - pharmacology Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Escherichia coli Escherichia coli - drug effects Escherichia coli - enzymology Inhibitor-resistant β-lactamase Kinetics Penicillanic Acid - analogs & derivatives Penicillanic Acid - metabolism Penicillanic Acid - pharmacology Penicillins - pharmacology Piperacillin Piperacillin - pharmacology Tazobactam
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