Decreased expression of HLA class I on ocular melanoma cells following in vitro photodynamic therapy
Our objective was to investigate whether photodynamic therapy (PDT) influences the expression of HLA Class I and β2-microglobulin molecules on cultured uveal melanoma cells. Uveal melanoma cells were incubated with hematoporphyrin esters (HPE) and illuminated using red light. HLA expression on cells...
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| Veröffentlicht in: | Cancer letters 1997-01, Vol.112 (2), p.239-243 |
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| container_title | Cancer letters |
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| creator | Blom, Derk-Jan R. Schuitmaker, Hans J. de Waard-Siebinga, Itte Dubbelman, Tom M.A.R. Jager, Martine J. |
| description | Our objective was to investigate whether photodynamic therapy (PDT) influences the expression of HLA Class I and β2-microglobulin molecules on cultured uveal melanoma cells. Uveal melanoma cells were incubated with hematoporphyrin esters (HPE) and illuminated using red light. HLA expression on cells was determined by flowcytometry. PDT treatment induced an immediate reduction in expression of HLA Class I and β2-microglobulin, followed by a transient increase in expression after 2 h. Normalization occurred after 6 h. Treatment of ocular melanoma cells with PDT temporally alters the expression of HLA Class I and β2-microglobulin, which may affect anti-tumor-immune responses. |
| doi_str_mv | 10.1016/S0304-3835(96)04578-8 |
| format | Article |
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Uveal melanoma cells were incubated with hematoporphyrin esters (HPE) and illuminated using red light. HLA expression on cells was determined by flowcytometry. PDT treatment induced an immediate reduction in expression of HLA Class I and β2-microglobulin, followed by a transient increase in expression after 2 h. Normalization occurred after 6 h. Treatment of ocular melanoma cells with PDT temporally alters the expression of HLA Class I and β2-microglobulin, which may affect anti-tumor-immune responses.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(96)04578-8</identifier><identifier>PMID: 9066734</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Antigens, Neoplasm - biosynthesis ; beta 2-Microglobulin - biosynthesis ; Biological and medical sciences ; Flow Cytometry ; Hematoporphyrins - pharmacology ; Histocompatibility Antigens Class I - biosynthesis ; HLA Class I antigens ; Humans ; Medical sciences ; Melanoma - drug therapy ; Melanoma - metabolism ; Photochemotherapy ; Photodynamic treatment ; Photoradiation therapy and photosensitizing agent ; Photosensitizing Agents - pharmacology ; Treatment with physical agents ; Treatment. General aspects ; Tumor Cells, Cultured ; Tumors ; Uveal melanoma ; Uveal Neoplasms - drug therapy ; Uveal Neoplasms - metabolism</subject><ispartof>Cancer letters, 1997-01, Vol.112 (2), p.239-243</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-44b0edeadc3037e81c8fffb256a2b49cca2d7a7168ee0afe4a8d09c1a1ecdf543</citedby><cites>FETCH-LOGICAL-c420t-44b0edeadc3037e81c8fffb256a2b49cca2d7a7168ee0afe4a8d09c1a1ecdf543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3835(96)04578-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2590458$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9066734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blom, Derk-Jan R.</creatorcontrib><creatorcontrib>Schuitmaker, Hans J.</creatorcontrib><creatorcontrib>de Waard-Siebinga, Itte</creatorcontrib><creatorcontrib>Dubbelman, Tom M.A.R.</creatorcontrib><creatorcontrib>Jager, Martine J.</creatorcontrib><title>Decreased expression of HLA class I on ocular melanoma cells following in vitro photodynamic therapy</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Our objective was to investigate whether photodynamic therapy (PDT) influences the expression of HLA Class I and β2-microglobulin molecules on cultured uveal melanoma cells. Uveal melanoma cells were incubated with hematoporphyrin esters (HPE) and illuminated using red light. HLA expression on cells was determined by flowcytometry. PDT treatment induced an immediate reduction in expression of HLA Class I and β2-microglobulin, followed by a transient increase in expression after 2 h. Normalization occurred after 6 h. Treatment of ocular melanoma cells with PDT temporally alters the expression of HLA Class I and β2-microglobulin, which may affect anti-tumor-immune responses.</description><subject>Antigens, Neoplasm - biosynthesis</subject><subject>beta 2-Microglobulin - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Flow Cytometry</subject><subject>Hematoporphyrins - pharmacology</subject><subject>Histocompatibility Antigens Class I - biosynthesis</subject><subject>HLA Class I antigens</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Melanoma - drug therapy</subject><subject>Melanoma - metabolism</subject><subject>Photochemotherapy</subject><subject>Photodynamic treatment</subject><subject>Photoradiation therapy and photosensitizing agent</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Treatment with physical agents</subject><subject>Treatment. 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| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1997-01, Vol.112 (2), p.239-243 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Antigens, Neoplasm - biosynthesis beta 2-Microglobulin - biosynthesis Biological and medical sciences Flow Cytometry Hematoporphyrins - pharmacology Histocompatibility Antigens Class I - biosynthesis HLA Class I antigens Humans Medical sciences Melanoma - drug therapy Melanoma - metabolism Photochemotherapy Photodynamic treatment Photoradiation therapy and photosensitizing agent Photosensitizing Agents - pharmacology Treatment with physical agents Treatment. General aspects Tumor Cells, Cultured Tumors Uveal melanoma Uveal Neoplasms - drug therapy Uveal Neoplasms - metabolism |
| title | Decreased expression of HLA class I on ocular melanoma cells following in vitro photodynamic therapy |
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