Expression of mdr1 and mrp in the normal B‐cell homologue of B‐cell chronic lymphocytic leukaemia

B‐cell chronic lymphocytic leukaemia (CLL) cells commonly express the multidrug resistance phenotype. The aim of this study was to establish whether the normal homologue in B‐cell ontogeny of B‐CLL also expressed the multidrug resistance (mdr) phenotype. Human tonsillar lymphocytes were sorted to yi...

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Veröffentlicht in:	British journal of haematology 1997-03, Vol.96 (4), p.697-707
Hauptverfasser:	WALL, D. M. P., EL‐OSTA, S., TZELEPIS, D., BERTONCELLO, I., KANTHARIDIS, P., CHOU, S. T., ZALCBERG, J. R., PARKIN, J. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents ATP Binding Cassette Transporter, Subfamily B ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism ATP-Binding Cassette Transporters - metabolism B-Lymphocyte Subsets Biological and medical sciences B‐CLL Drug Resistance, Multiple - genetics Drug Resistance, Neoplasm - genetics General aspects Humans Immunophenotyping Leukemia, B-Cell - metabolism mdr1 Medical sciences normal B‐cell homologues Pharmacology. Drug treatments Phenotype RNA, Messenger - metabolism T-Lymphocyte Subsets Tumor Cells, Cultured
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