Protective Effects of Murine Monoclonal Antibodies in Experimental Septicemia: E. coli Antibodies Protect Against Different Serotypes of E. coli
Murine monoclonal antibodies that bind outer membrane antigens of the J5 mutant of Escherichia coli O111 :B4 were derived from spleencells of BALB/c mice immunized with killed whole cells and boosted with lipopolysaccharide (LPS) and LPS-associated proteins. Seven hybridomas were selected for their...
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| Veröffentlicht in: | The Journal of infectious diseases 1989-04, Vol.159 (4), p.641-647 |
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| container_title | The Journal of infectious diseases |
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| creator | Salles, Marie-France Mandine, Eliane Zalisz, René Guenounou, Moncef Smets, Pierre |
| description | Murine monoclonal antibodies that bind outer membrane antigens of the J5 mutant of Escherichia coli O111 :B4 were derived from spleencells of BALB/c mice immunized with killed whole cells and boosted with lipopolysaccharide (LPS) and LPS-associated proteins. Seven hybridomas were selected for their reactivity against the J5 LPS; they cross-reacted with O111, O55, O127, and O128 E. coli LPS. One (B7B3) also reacted with the Serratia marcescens LPS and Klebsiella pneumoniae lipid A. A protective effect was obtained with D6B4 antibody in a lethal endotoxemia model induced by LPS from O111, O127, and O128 E. coli serotypes in D-galactosamine-sensitized mice. D6B4 and D6B3 antibodies protected mice infected with E. coli O111:B4, when administered before infection. The D6B4 antibody was also protective when administered after infection. The antibodies D6B3 and D4B5 were protective in heterologous infection induced byE. coli O2:K1. |
| doi_str_mv | 10.1093/infdis/159.4.641 |
| format | Article |
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Seven hybridomas were selected for their reactivity against the J5 LPS; they cross-reacted with O111, O55, O127, and O128 E. coli LPS. One (B7B3) also reacted with the Serratia marcescens LPS and Klebsiella pneumoniae lipid A. A protective effect was obtained with D6B4 antibody in a lethal endotoxemia model induced by LPS from O111, O127, and O128 E. coli serotypes in D-galactosamine-sensitized mice. D6B4 and D6B3 antibodies protected mice infected with E. coli O111:B4, when administered before infection. The D6B4 antibody was also protective when administered after infection. The antibodies D6B3 and D4B5 were protective in heterologous infection induced byE. coli O2:K1.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/159.4.641</identifier><identifier>PMID: 2647860</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Animals ; Antibodies ; Antibodies, Bacterial - immunology ; Antibodies, Monoclonal - immunology ; Antibodies, Monoclonal - therapeutic use ; Antibody Specificity ; Antigens ; Bacteria ; Cross Reactions ; Endotoxins ; Enzyme-Linked Immunosorbent Assay ; Escherichia coli ; Escherichia coli - immunology ; Escherichia coli Infections - immunology ; Escherichia coli Infections - prevention & control ; Female ; Hybridomas ; Infections ; Lipids ; Lipopolysaccharides ; Lipopolysaccharides - immunology ; Mice ; Monoclonal antibodies ; Original Articles ; Sepsis - immunology ; Sepsis - prevention & control</subject><ispartof>The Journal of infectious diseases, 1989-04, Vol.159 (4), p.641-647</ispartof><rights>Copyright 1989 The University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c300t-9fad2b7e5fc19e1d93c25e43a569f97188ae769eccf9d5f3714e6570f510fe6c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30137091$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30137091$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2647860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Salles, Marie-France</creatorcontrib><creatorcontrib>Mandine, Eliane</creatorcontrib><creatorcontrib>Zalisz, René</creatorcontrib><creatorcontrib>Guenounou, Moncef</creatorcontrib><creatorcontrib>Smets, Pierre</creatorcontrib><title>Protective Effects of Murine Monoclonal Antibodies in Experimental Septicemia: E. coli Antibodies Protect Against Different Serotypes of E. coli</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Murine monoclonal antibodies that bind outer membrane antigens of the J5 mutant of Escherichia coli O111 :B4 were derived from spleencells of BALB/c mice immunized with killed whole cells and boosted with lipopolysaccharide (LPS) and LPS-associated proteins. Seven hybridomas were selected for their reactivity against the J5 LPS; they cross-reacted with O111, O55, O127, and O128 E. coli LPS. One (B7B3) also reacted with the Serratia marcescens LPS and Klebsiella pneumoniae lipid A. A protective effect was obtained with D6B4 antibody in a lethal endotoxemia model induced by LPS from O111, O127, and O128 E. coli serotypes in D-galactosamine-sensitized mice. D6B4 and D6B3 antibodies protected mice infected with E. coli O111:B4, when administered before infection. The D6B4 antibody was also protective when administered after infection. The antibodies D6B3 and D4B5 were protective in heterologous infection induced byE. coli O2:K1.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Antibody Specificity</subject><subject>Antigens</subject><subject>Bacteria</subject><subject>Cross Reactions</subject><subject>Endotoxins</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Escherichia coli</subject><subject>Escherichia coli - immunology</subject><subject>Escherichia coli Infections - immunology</subject><subject>Escherichia coli Infections - prevention & control</subject><subject>Female</subject><subject>Hybridomas</subject><subject>Infections</subject><subject>Lipids</subject><subject>Lipopolysaccharides</subject><subject>Lipopolysaccharides - immunology</subject><subject>Mice</subject><subject>Monoclonal antibodies</subject><subject>Original Articles</subject><subject>Sepsis - immunology</subject><subject>Sepsis - prevention & control</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFvFCEYxYnR1LV692LCydtsYRhg8LZ2V2vSjZrWxHghLPNhqLPDFFjT_hf-yVJnsnrzBMl7v-8l7yH0kpIlJYqd-cF1Pp1RrpbNUjT0EVpQzmQlBGWP0YKQuq5oq9RT9CylG0JIw4Q8QSe1aGQryAL9-hRDBpv9T8Ab58ov4eDw9hD9AHgbhmD7MJger4bsd6HzkLAf8OZuhOj3MOQiXcGYvYW9N2_wZolt6P2_9jkBr74bP6SM177kxIIWsEj3I_yJnMnn6IkzfYIX83uKvrzbXJ9fVJcf3384X11WlhGSK-VMV-8kcGepAtopZmsODTNcKKckbVsDUiiw1qmOOyZpA4JL4jglDoRlp-j1dHeM4fYAKeu9Txb63gwQDknLtm1JafG_RsobXuqkxUgmo40hpQhOj6UiE-81JfphLT2tVQilGz0hr-bbh90euiMwz_NXv0k5xKPMCGWSqAe-mnSfMtwddRN_aCGZ5Pri6ze9XV-_rT-vlb5ivwFqoayF</recordid><startdate>198904</startdate><enddate>198904</enddate><creator>Salles, Marie-France</creator><creator>Mandine, Eliane</creator><creator>Zalisz, René</creator><creator>Guenounou, Moncef</creator><creator>Smets, Pierre</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198904</creationdate><title>Protective Effects of Murine Monoclonal Antibodies in Experimental Septicemia: E. coli Antibodies Protect Against Different Serotypes of E. coli</title><author>Salles, Marie-France ; Mandine, Eliane ; Zalisz, René ; Guenounou, Moncef ; Smets, Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-9fad2b7e5fc19e1d93c25e43a569f97188ae769eccf9d5f3714e6570f510fe6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Bacterial - immunology</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Antibody Specificity</topic><topic>Antigens</topic><topic>Bacteria</topic><topic>Cross Reactions</topic><topic>Endotoxins</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Escherichia coli</topic><topic>Escherichia coli - immunology</topic><topic>Escherichia coli Infections - immunology</topic><topic>Escherichia coli Infections - prevention & control</topic><topic>Female</topic><topic>Hybridomas</topic><topic>Infections</topic><topic>Lipids</topic><topic>Lipopolysaccharides</topic><topic>Lipopolysaccharides - immunology</topic><topic>Mice</topic><topic>Monoclonal antibodies</topic><topic>Original Articles</topic><topic>Sepsis - immunology</topic><topic>Sepsis - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salles, Marie-France</creatorcontrib><creatorcontrib>Mandine, Eliane</creatorcontrib><creatorcontrib>Zalisz, René</creatorcontrib><creatorcontrib>Guenounou, Moncef</creatorcontrib><creatorcontrib>Smets, Pierre</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salles, Marie-France</au><au>Mandine, Eliane</au><au>Zalisz, René</au><au>Guenounou, Moncef</au><au>Smets, Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective Effects of Murine Monoclonal Antibodies in Experimental Septicemia: E. coli Antibodies Protect Against Different Serotypes of E. coli</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1989-04</date><risdate>1989</risdate><volume>159</volume><issue>4</issue><spage>641</spage><epage>647</epage><pages>641-647</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Murine monoclonal antibodies that bind outer membrane antigens of the J5 mutant of Escherichia coli O111 :B4 were derived from spleencells of BALB/c mice immunized with killed whole cells and boosted with lipopolysaccharide (LPS) and LPS-associated proteins. Seven hybridomas were selected for their reactivity against the J5 LPS; they cross-reacted with O111, O55, O127, and O128 E. coli LPS. One (B7B3) also reacted with the Serratia marcescens LPS and Klebsiella pneumoniae lipid A. A protective effect was obtained with D6B4 antibody in a lethal endotoxemia model induced by LPS from O111, O127, and O128 E. coli serotypes in D-galactosamine-sensitized mice. D6B4 and D6B3 antibodies protected mice infected with E. coli O111:B4, when administered before infection. The D6B4 antibody was also protective when administered after infection. The antibodies D6B3 and D4B5 were protective in heterologous infection induced byE. coli O2:K1.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>2647860</pmid><doi>10.1093/infdis/159.4.641</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Antibodies Antibodies, Bacterial - immunology Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antibody Specificity Antigens Bacteria Cross Reactions Endotoxins Enzyme-Linked Immunosorbent Assay Escherichia coli Escherichia coli - immunology Escherichia coli Infections - immunology Escherichia coli Infections - prevention & control Female Hybridomas Infections Lipids Lipopolysaccharides Lipopolysaccharides - immunology Mice Monoclonal antibodies Original Articles Sepsis - immunology Sepsis - prevention & control |
| title | Protective Effects of Murine Monoclonal Antibodies in Experimental Septicemia: E. coli Antibodies Protect Against Different Serotypes of E. coli |
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