Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts

The acute release of radicals upon reperfusion following myocardial ischemia may include both nitric oxide (NO) and superoxide anion (O2-.). The generation of peroxynitrite (ONOO-) from these radicals may contribute to ischemia-reperfusion injury. Our objective was to measure the generation of ONOO-...

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Veröffentlicht in:	Cardiovascular research 1997-02, Vol.33 (2), p.422-432
Hauptverfasser:	YASMIN, W, STRYNADKA, K. D, SCHULZ, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiology. Vascular system Coronary heart disease Heart Male Medical sciences Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - prevention & control Myocardium - metabolism Nitrates - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors omega-N-Methylarginine - pharmacology Penicillamine - analogs & derivatives Penicillamine - pharmacology Perfusion Rats Rats, Sprague-Dawley S-Nitroso-N-Acetylpenicillamine Vasodilator Agents - pharmacology
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