Gastric ulcer recurrence: follow-up of a double-blind, placebo-controlled trial
Following a multicenter, double-blind trial comparing cimetidine, antacid, and placebo for the treatment of gastric ulcer, patients whose ulcers had healed were followed prospectively to assess the frequency of ulcer relapse. Fifty-eight patients entered the follow-up study. Patients were encouraged...
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| Veröffentlicht in: | Journal of clinical gastroenterology 1989-02, Vol.11 (1), p.12-16 |
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| container_title | Journal of clinical gastroenterology |
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| creator | WOLOSIN, J. D GERTLER, S. L PETERSON, W. L SANDERSFELD, M. A ISENBERG, J. I |
| description | Following a multicenter, double-blind trial comparing cimetidine, antacid, and placebo for the treatment of gastric ulcer, patients whose ulcers had healed were followed prospectively to assess the frequency of ulcer relapse. Fifty-eight patients entered the follow-up study. Patients were encouraged to discontinue smoking and excessive ethanol intake, but were not maintained on antiulcer medications. Clinical evaluation was performed at monthly intervals; repeat endoscopy was performed at the time of symptom recurrence or at 6 to 9 months after ulcer healing. Gastric ulcer recurred in 20 of 58 patients (35%). While 15 (75%) with ulcer recurrence had symptoms, 5 (25%) had asymptomatic recurrences. There were no differences in the incidence of ulcer relapse or symptom recurrences between groups. We conclude that gastric ulcers recur in approximately one-third of patients within 9 months of ulcer healing. |
| doi_str_mv | 10.1097/00004836-198902000-00004 |
| format | Article |
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D ; GERTLER, S. L ; PETERSON, W. L ; SANDERSFELD, M. A ; ISENBERG, J. I</creator><creatorcontrib>WOLOSIN, J. D ; GERTLER, S. L ; PETERSON, W. L ; SANDERSFELD, M. A ; ISENBERG, J. I</creatorcontrib><description>Following a multicenter, double-blind trial comparing cimetidine, antacid, and placebo for the treatment of gastric ulcer, patients whose ulcers had healed were followed prospectively to assess the frequency of ulcer relapse. Fifty-eight patients entered the follow-up study. Patients were encouraged to discontinue smoking and excessive ethanol intake, but were not maintained on antiulcer medications. Clinical evaluation was performed at monthly intervals; repeat endoscopy was performed at the time of symptom recurrence or at 6 to 9 months after ulcer healing. Gastric ulcer recurred in 20 of 58 patients (35%). While 15 (75%) with ulcer recurrence had symptoms, 5 (25%) had asymptomatic recurrences. There were no differences in the incidence of ulcer relapse or symptom recurrences between groups. We conclude that gastric ulcers recur in approximately one-third of patients within 9 months of ulcer healing.</description><identifier>ISSN: 0192-0790</identifier><identifier>EISSN: 1539-2031</identifier><identifier>DOI: 10.1097/00004836-198902000-00004</identifier><identifier>PMID: 2646357</identifier><identifier>CODEN: JCGADC</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Antacids - therapeutic use ; Biological and medical sciences ; Cimetidine - therapeutic use ; Clinical Trials as Topic ; Cohort Studies ; Digestive system ; Double-Blind Method ; Female ; Follow-Up Studies ; Gastroscopy ; Humans ; Male ; Medical sciences ; Middle Aged ; Multicenter Studies as Topic ; Pharmacology. 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L</creatorcontrib><creatorcontrib>SANDERSFELD, M. A</creatorcontrib><creatorcontrib>ISENBERG, J. I</creatorcontrib><title>Gastric ulcer recurrence: follow-up of a double-blind, placebo-controlled trial</title><title>Journal of clinical gastroenterology</title><addtitle>J Clin Gastroenterol</addtitle><description>Following a multicenter, double-blind trial comparing cimetidine, antacid, and placebo for the treatment of gastric ulcer, patients whose ulcers had healed were followed prospectively to assess the frequency of ulcer relapse. Fifty-eight patients entered the follow-up study. Patients were encouraged to discontinue smoking and excessive ethanol intake, but were not maintained on antiulcer medications. Clinical evaluation was performed at monthly intervals; repeat endoscopy was performed at the time of symptom recurrence or at 6 to 9 months after ulcer healing. Gastric ulcer recurred in 20 of 58 patients (35%). While 15 (75%) with ulcer recurrence had symptoms, 5 (25%) had asymptomatic recurrences. There were no differences in the incidence of ulcer relapse or symptom recurrences between groups. We conclude that gastric ulcers recur in approximately one-third of patients within 9 months of ulcer healing.</description><subject>Adult</subject><subject>Aged</subject><subject>Antacids - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cimetidine - therapeutic use</subject><subject>Clinical Trials as Topic</subject><subject>Cohort Studies</subject><subject>Digestive system</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroscopy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multicenter Studies as Topic</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Recurrence</subject><subject>Stomach Ulcer - drug therapy</subject><subject>Stomach Ulcer - epidemiology</subject><issn>0192-0790</issn><issn>1539-2031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFKxDAQhoMo67r6CEIO4sloJkmbxpuIrsLCXvRcknQKlWxbkxbx7Q1anMsw8398MEMIBX4L3Og7nktVsmRgKsNFntjv6oisoZCGCS7hmKw5GMG4NvyUnKX0wTloKWFFVqJUpSz0muy3Nk2x83QOHiON6OcYsfd4T9shhOGLzSMdWmppM8wuIHOh65sbOgbr0Q3MD_0UM4gNzRobzslJa0PCi6VvyPvz09vjC9vtt6-PDzs2QqknhuhFAdwb5TS0whuubOm8qACMUrIpWtc2ulJgwEjr0GihhFUm32IRuJQbcv3nHePwOWOa6kOXPIZgexzmVOuq0qYwkMHLBZzdAZt6jN3Bxu96-UDOr5bcJm9DG23vu_SPldpkiZA_8WJqtw</recordid><startdate>19890201</startdate><enddate>19890201</enddate><creator>WOLOSIN, J. D</creator><creator>GERTLER, S. L</creator><creator>PETERSON, W. L</creator><creator>SANDERSFELD, M. A</creator><creator>ISENBERG, J. 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I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p167t-eec2510c94b71f2c904a6bc28119443d5fbfd78419193abe97242a49079ae1033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antacids - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cimetidine - therapeutic use</topic><topic>Clinical Trials as Topic</topic><topic>Cohort Studies</topic><topic>Digestive system</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroscopy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multicenter Studies as Topic</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Recurrence</topic><topic>Stomach Ulcer - drug therapy</topic><topic>Stomach Ulcer - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WOLOSIN, J. D</creatorcontrib><creatorcontrib>GERTLER, S. L</creatorcontrib><creatorcontrib>PETERSON, W. L</creatorcontrib><creatorcontrib>SANDERSFELD, M. A</creatorcontrib><creatorcontrib>ISENBERG, J. I</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Journal of clinical gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WOLOSIN, J. D</au><au>GERTLER, S. L</au><au>PETERSON, W. L</au><au>SANDERSFELD, M. A</au><au>ISENBERG, J. I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastric ulcer recurrence: follow-up of a double-blind, placebo-controlled trial</atitle><jtitle>Journal of clinical gastroenterology</jtitle><addtitle>J Clin Gastroenterol</addtitle><date>1989-02-01</date><risdate>1989</risdate><volume>11</volume><issue>1</issue><spage>12</spage><epage>16</epage><pages>12-16</pages><issn>0192-0790</issn><eissn>1539-2031</eissn><coden>JCGADC</coden><abstract>Following a multicenter, double-blind trial comparing cimetidine, antacid, and placebo for the treatment of gastric ulcer, patients whose ulcers had healed were followed prospectively to assess the frequency of ulcer relapse. Fifty-eight patients entered the follow-up study. Patients were encouraged to discontinue smoking and excessive ethanol intake, but were not maintained on antiulcer medications. Clinical evaluation was performed at monthly intervals; repeat endoscopy was performed at the time of symptom recurrence or at 6 to 9 months after ulcer healing. Gastric ulcer recurred in 20 of 58 patients (35%). While 15 (75%) with ulcer recurrence had symptoms, 5 (25%) had asymptomatic recurrences. There were no differences in the incidence of ulcer relapse or symptom recurrences between groups. We conclude that gastric ulcers recur in approximately one-third of patients within 9 months of ulcer healing.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>2646357</pmid><doi>10.1097/00004836-198902000-00004</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0192-0790 |
| ispartof | Journal of clinical gastroenterology, 1989-02, Vol.11 (1), p.12-16 |
| issn | 0192-0790 1539-2031 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Antacids - therapeutic use Biological and medical sciences Cimetidine - therapeutic use Clinical Trials as Topic Cohort Studies Digestive system Double-Blind Method Female Follow-Up Studies Gastroscopy Humans Male Medical sciences Middle Aged Multicenter Studies as Topic Pharmacology. Drug treatments Prospective Studies Recurrence Stomach Ulcer - drug therapy Stomach Ulcer - epidemiology |
| title | Gastric ulcer recurrence: follow-up of a double-blind, placebo-controlled trial |
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