Antiproliferative effect of gossypol and its optical isomers on human reproductive cancer cell lines

The antiproliferative effect of gossypol and its optical isomers on various human cell lines of reproductive and nonreproductive tissue origin was studied. Various reproductive cancer cell lines of ovarian, gestational, and testicular origin were highly sensitive (IC50 values of 0.86–1.98) to gossyp...

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Veröffentlicht in:	Gynecologic oncology 1989-03, Vol.32 (3), p.273-277
Hauptverfasser:	Band, Vimla, Hoffer, Anita P., Band, Hamid, Rhinehardt, Ann E., Knapp, Robert C., Matlin, Stephen A., Anderson, Deborah J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacokinetics Biological and medical sciences Cell Division - drug effects Cell Line Chemotherapy DNA, Neoplasm - biosynthesis Dose-Response Relationship, Drug Female Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Genital Neoplasms, Female - metabolism Genital Neoplasms, Female - pathology Genital Neoplasms, Male - metabolism Genital Neoplasms, Male - pathology Gossypol - analogs & derivatives Gossypol - pharmacology Humans Isomerism Leucine - metabolism Leukemia, Experimental - metabolism Leukemia, Experimental - pathology Male Medical sciences Mitochondria - metabolism Neoplasm Proteins - biosynthesis Pharmacology. Drug treatments Rhodamine 123 Rhodamines - pharmacokinetics
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