Susceptibility to natural killer cell-mediated cytolysis is independent of the level of target cell class I HLA expression

To test the hypothesis that susceptibility to NK cell-mediated cytolysis varies inversely with the levels of target cell class I HLA expression, NK-susceptible K562 and MOLT-4 target cells have been transfected via electroporation with cloned human class I HLA-A2 and HLA-B7 genes. Stably transfected...

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Veröffentlicht in:	The Journal of immunology (1950) 1989-03, Vol.142 (6), p.2140-2147
Hauptverfasser:	Leiden, JM, Karpinski, BA, Gottschalk, L, Kornbluth, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Cytotoxicity, Immunologic - drug effects Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - isolation & purification Humans Immunity, Cellular - drug effects Immunity, Innate - drug effects Interferon-gamma - pharmacology Killer Cells, Natural - immunology Leukemia, Erythroblastic, Acute - genetics Leukemia, Erythroblastic, Acute - immunology Leukemia, T-Cell - genetics Leukemia, T-Cell - immunology Transfection
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