Effects of ulinastatin on experimental ulcerative colitis in rats

We examined the effect of ulinastatin in comparison with prednisolone (PSL) and salazosulfapyridine (SASP), well-known drugs for ulcerative colitis (UC), on two experimental UC models induced by dextran sulfate sodium (DSS) or trinitrobenzene sulfonic acid (TNB) in rats. Ulinastatin at the doses of...

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Veröffentlicht in:	Folia Pharmacologica Japonica 1997, Vol.109(1), pp.41-52
Hauptverfasser:	NAGAO, Yuji, MIYATA, Haruo, MIZUGUCHI, Kiyoshi, BAN, Minako, KATO, Katsuaki
Format:	Artikel
Sprache:	jpn
Schlagworte:	Animals Cathepsin G Cathepsins - antagonists & inhibitors Colitis, Ulcerative - drug therapy Female Glycoproteins - administration & dosage Glycoproteins - pharmacology Glycoproteins - therapeutic use Humans Interleukin-8 - biosynthesis Leukocyte Elastase - antagonists & inhibitors Leukocytes - enzymology Macrophages, Peritoneal - metabolism Male Prednisolone - therapeutic use Rabbits Rats Rats, Sprague-Dawley Rats, Wistar Serine Endopeptidases Sulfasalazine - therapeutic use Trypsin Inhibitors - administration & dosage Trypsin Inhibitors - pharmacology Trypsin Inhibitors - therapeutic use Tumor Necrosis Factor-alpha - biosynthesis
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