Apoptotic hepatocytes become insoluble in detergents and chaotropic agents as a result of transglutaminase action

Physiological deletion of cells ensues programmed death which involves formation of apoptotic bodies with fragmented DNA. Here we report that apoptotic hepatocytes are insoluble in detergents, urea, guanidine hydrochloride, reducing agents and thereby can be isolated from rat liver following collage...

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Veröffentlicht in:	FEBS letters 1989-03, Vol.245 (1), p.150-154
Hauptverfasser:	Fesus, Laszlo, Thomazy, Vilmos, Autuori, Francesco, Ceru, Maria P., Tarcsa, Edit, Piacentini, Mauro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Detergents Dipeptides DNA - metabolism Guanidine Guanidines Hot Temperature Liver - cytology Liver - enzymology Liver - physiology Male Mercaptoethanol Microscopy, Electron, Scanning Protein crosslinkage protein-glutamine gamma -glutamyltransferase Rats Rats, Inbred Strains Sodium Dodecyl Sulfate Solubility Spermidine - analogs & derivatives Surface-Active Agents Terminal differentiation Transglutaminase Transglutaminases - metabolism Urea
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