Relation of Donor Age and Preexisting Coronary Artery Disease on Angiography and Intracoronary Ultrasound to Later Development of Accelerated Allograft Coronary Artery Disease
Objectives. This study assessed the influence of donor age and preexisting donor coronary artery disease on the later development of allograft coronary artery disease, ischemic events and overall survival. Background. The increasing demand for heart donors has led to a tendency to liberalize age cri...
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| Veröffentlicht in: | Journal of the American College of Cardiology 1997-03, Vol.29 (3), p.623-629 |
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| creator | Gao, Shao-Zhou Hunt, Sharon A Alderman, Edwin L Liang, David Yeung, Alan C Schroeder, John S |
| description | Objectives. This study assessed the influence of donor age and preexisting donor coronary artery disease on the later development of allograft coronary artery disease, ischemic events and overall survival.
Background. The increasing demand for heart donors has led to a tendency to liberalize age criteria for donor acceptability.
Methods. A total of 233 consecutive heart transplant recipients who had baseline, early postoperative and follow-up coronary angiograms, as well as a subset of 47 patients with baseline intracoronary ultrasound imaging recordings, were analyzed (mean 3.8 years of follow-up). Patients were subclassified according to the presence of donor coronary artery disease on the baseline angiogram and stratified at age 40 years.
Results. Patients without evidence of preexisting coronary artery disease on a baseline angiogram (n = 219) were significantly less likely to develop new disease than the 14 patients with preexisting coronary artery disease (p = 0.002). Although older donors exhibited earlier coronary artery disease than younger donors at 3 years of follow-up, there was no difference by 5 years (p = 0.25). There was no difference in survival or probability of developing ischemic events between the groups. Baseline ultrasound imaging revealed substantial disease in 7 of 9 older donated hearts, and in only 7 of 38 younger donated hearts (p = 0.002). Preexisting coronary artery disease, nonuse of calcium channel blocking agents, older donor age, posttransplantation cytomegalovirus infection, elevated very low density lipoprotein levels and previous ischemic heart disease in the recipient were significant predictors of allograft coronary artery disease.
Conclusions. Heart donors with angiographic evidence of pre-existing coronary artery disease and older donors are more likely to develop new allograft coronary artery disease by 3 years. However, there is no difference in patient survival or freedom from ischemic events between younger and older donors at a mean follow-up of 3.8 years.
(J Am Coll Cardiol 1997;29:623–9) |
| doi_str_mv | 10.1016/S0735-1097(96)00521-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78873371</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0735109796005219</els_id><sourcerecordid>78873371</sourcerecordid><originalsourceid>FETCH-LOGICAL-c536t-49041afc0f5173534ec29990258a7da37ecc244fca6e8723e104082b1209c1ad3</originalsourceid><addsrcrecordid>eNqFkd1uEzEQhS0EKqHwCJV8gRBcLB3vrtfrK7RK-KkUqQjoteV6Z4ORYwfbqehT8Yp1fsgd6tXIOt-ZGc8h5ILBewasu_wOouEVAyneyu4dAK9ZJZ-QGeO8rxouxVMyOyHPyYuUfgFA1zN5Rs4kdCChnpG_39DpbIOnYaKL4EOkwwqp9iP9GhH_2JStX9F5iMHreE-HmLGUhU2oE9LiG_zKhlXUm5_3e9uVz1Gbf_yNK68UtkXIgS51cdMF3qELmzX6vJs6GIMOY5FGOji36zXl_018SZ5N2iV8dazn5ObTxx_zL9Xy-vPVfFhWhjddrloJLdOTgYmzcoOmRVNLWX7Mey1G3Qg0pm7byegOe1E3yKCFvr5lNUjD9NickzeHvpsYfm8xZbW2qezptMewTUr0vWgawQrID6CJIaWIk9pEuy6LKwZqF5TaB6V2KSjZqX1QShbfxXHA9naN48l1TKbor4-6Tka7KWpvbDphNZcMOC_YhwOG5Rh3FqNKxqI3ONqIJqsx2EcWeQDkjbJL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78873371</pqid></control><display><type>article</type><title>Relation of Donor Age and Preexisting Coronary Artery Disease on Angiography and Intracoronary Ultrasound to Later Development of Accelerated Allograft Coronary Artery Disease</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Gao, Shao-Zhou ; Hunt, Sharon A ; Alderman, Edwin L ; Liang, David ; Yeung, Alan C ; Schroeder, John S</creator><creatorcontrib>Gao, Shao-Zhou ; Hunt, Sharon A ; Alderman, Edwin L ; Liang, David ; Yeung, Alan C ; Schroeder, John S</creatorcontrib><description>Objectives. This study assessed the influence of donor age and preexisting donor coronary artery disease on the later development of allograft coronary artery disease, ischemic events and overall survival.
Background. The increasing demand for heart donors has led to a tendency to liberalize age criteria for donor acceptability.
Methods. A total of 233 consecutive heart transplant recipients who had baseline, early postoperative and follow-up coronary angiograms, as well as a subset of 47 patients with baseline intracoronary ultrasound imaging recordings, were analyzed (mean 3.8 years of follow-up). Patients were subclassified according to the presence of donor coronary artery disease on the baseline angiogram and stratified at age 40 years.
Results. Patients without evidence of preexisting coronary artery disease on a baseline angiogram (n = 219) were significantly less likely to develop new disease than the 14 patients with preexisting coronary artery disease (p = 0.002). Although older donors exhibited earlier coronary artery disease than younger donors at 3 years of follow-up, there was no difference by 5 years (p = 0.25). There was no difference in survival or probability of developing ischemic events between the groups. Baseline ultrasound imaging revealed substantial disease in 7 of 9 older donated hearts, and in only 7 of 38 younger donated hearts (p = 0.002). Preexisting coronary artery disease, nonuse of calcium channel blocking agents, older donor age, posttransplantation cytomegalovirus infection, elevated very low density lipoprotein levels and previous ischemic heart disease in the recipient were significant predictors of allograft coronary artery disease.
Conclusions. Heart donors with angiographic evidence of pre-existing coronary artery disease and older donors are more likely to develop new allograft coronary artery disease by 3 years. However, there is no difference in patient survival or freedom from ischemic events between younger and older donors at a mean follow-up of 3.8 years.
(J Am Coll Cardiol 1997;29:623–9)</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/S0735-1097(96)00521-9</identifier><identifier>PMID: 9060902</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Age Factors ; Biological and medical sciences ; Coronary Angiography ; Coronary Disease - diagnostic imaging ; Coronary Disease - etiology ; Disease Progression ; Heart Transplantation ; Humans ; Medical sciences ; Postoperative Complications ; Retrospective Studies ; Risk Factors ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Tissue Donors ; Transplantation, Homologous ; Ultrasonography, Interventional</subject><ispartof>Journal of the American College of Cardiology, 1997-03, Vol.29 (3), p.623-629</ispartof><rights>1997 The American College of Cardiology</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-49041afc0f5173534ec29990258a7da37ecc244fca6e8723e104082b1209c1ad3</citedby><cites>FETCH-LOGICAL-c536t-49041afc0f5173534ec29990258a7da37ecc244fca6e8723e104082b1209c1ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0735-1097(96)00521-9$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2591055$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9060902$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Shao-Zhou</creatorcontrib><creatorcontrib>Hunt, Sharon A</creatorcontrib><creatorcontrib>Alderman, Edwin L</creatorcontrib><creatorcontrib>Liang, David</creatorcontrib><creatorcontrib>Yeung, Alan C</creatorcontrib><creatorcontrib>Schroeder, John S</creatorcontrib><title>Relation of Donor Age and Preexisting Coronary Artery Disease on Angiography and Intracoronary Ultrasound to Later Development of Accelerated Allograft Coronary Artery Disease</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Objectives. This study assessed the influence of donor age and preexisting donor coronary artery disease on the later development of allograft coronary artery disease, ischemic events and overall survival.
Background. The increasing demand for heart donors has led to a tendency to liberalize age criteria for donor acceptability.
Methods. A total of 233 consecutive heart transplant recipients who had baseline, early postoperative and follow-up coronary angiograms, as well as a subset of 47 patients with baseline intracoronary ultrasound imaging recordings, were analyzed (mean 3.8 years of follow-up). Patients were subclassified according to the presence of donor coronary artery disease on the baseline angiogram and stratified at age 40 years.
Results. Patients without evidence of preexisting coronary artery disease on a baseline angiogram (n = 219) were significantly less likely to develop new disease than the 14 patients with preexisting coronary artery disease (p = 0.002). Although older donors exhibited earlier coronary artery disease than younger donors at 3 years of follow-up, there was no difference by 5 years (p = 0.25). There was no difference in survival or probability of developing ischemic events between the groups. Baseline ultrasound imaging revealed substantial disease in 7 of 9 older donated hearts, and in only 7 of 38 younger donated hearts (p = 0.002). Preexisting coronary artery disease, nonuse of calcium channel blocking agents, older donor age, posttransplantation cytomegalovirus infection, elevated very low density lipoprotein levels and previous ischemic heart disease in the recipient were significant predictors of allograft coronary artery disease.
Conclusions. Heart donors with angiographic evidence of pre-existing coronary artery disease and older donors are more likely to develop new allograft coronary artery disease by 3 years. However, there is no difference in patient survival or freedom from ischemic events between younger and older donors at a mean follow-up of 3.8 years.
(J Am Coll Cardiol 1997;29:623–9)</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Coronary Angiography</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - etiology</subject><subject>Disease Progression</subject><subject>Heart Transplantation</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Postoperative Complications</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Tissue Donors</subject><subject>Transplantation, Homologous</subject><subject>Ultrasonography, Interventional</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd1uEzEQhS0EKqHwCJV8gRBcLB3vrtfrK7RK-KkUqQjoteV6Z4ORYwfbqehT8Yp1fsgd6tXIOt-ZGc8h5ILBewasu_wOouEVAyneyu4dAK9ZJZ-QGeO8rxouxVMyOyHPyYuUfgFA1zN5Rs4kdCChnpG_39DpbIOnYaKL4EOkwwqp9iP9GhH_2JStX9F5iMHreE-HmLGUhU2oE9LiG_zKhlXUm5_3e9uVz1Gbf_yNK68UtkXIgS51cdMF3qELmzX6vJs6GIMOY5FGOji36zXl_018SZ5N2iV8dazn5ObTxx_zL9Xy-vPVfFhWhjddrloJLdOTgYmzcoOmRVNLWX7Mey1G3Qg0pm7byegOe1E3yKCFvr5lNUjD9NickzeHvpsYfm8xZbW2qezptMewTUr0vWgawQrID6CJIaWIk9pEuy6LKwZqF5TaB6V2KSjZqX1QShbfxXHA9naN48l1TKbor4-6Tka7KWpvbDphNZcMOC_YhwOG5Rh3FqNKxqI3ONqIJqsx2EcWeQDkjbJL</recordid><startdate>19970301</startdate><enddate>19970301</enddate><creator>Gao, Shao-Zhou</creator><creator>Hunt, Sharon A</creator><creator>Alderman, Edwin L</creator><creator>Liang, David</creator><creator>Yeung, Alan C</creator><creator>Schroeder, John S</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970301</creationdate><title>Relation of Donor Age and Preexisting Coronary Artery Disease on Angiography and Intracoronary Ultrasound to Later Development of Accelerated Allograft Coronary Artery Disease</title><author>Gao, Shao-Zhou ; Hunt, Sharon A ; Alderman, Edwin L ; Liang, David ; Yeung, Alan C ; Schroeder, John S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-49041afc0f5173534ec29990258a7da37ecc244fca6e8723e104082b1209c1ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Coronary Angiography</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Coronary Disease - etiology</topic><topic>Disease Progression</topic><topic>Heart Transplantation</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Postoperative Complications</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Tissue Donors</topic><topic>Transplantation, Homologous</topic><topic>Ultrasonography, Interventional</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Shao-Zhou</creatorcontrib><creatorcontrib>Hunt, Sharon A</creatorcontrib><creatorcontrib>Alderman, Edwin L</creatorcontrib><creatorcontrib>Liang, David</creatorcontrib><creatorcontrib>Yeung, Alan C</creatorcontrib><creatorcontrib>Schroeder, John S</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Shao-Zhou</au><au>Hunt, Sharon A</au><au>Alderman, Edwin L</au><au>Liang, David</au><au>Yeung, Alan C</au><au>Schroeder, John S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation of Donor Age and Preexisting Coronary Artery Disease on Angiography and Intracoronary Ultrasound to Later Development of Accelerated Allograft Coronary Artery Disease</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>1997-03-01</date><risdate>1997</risdate><volume>29</volume><issue>3</issue><spage>623</spage><epage>629</epage><pages>623-629</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>Objectives. This study assessed the influence of donor age and preexisting donor coronary artery disease on the later development of allograft coronary artery disease, ischemic events and overall survival.
Background. The increasing demand for heart donors has led to a tendency to liberalize age criteria for donor acceptability.
Methods. A total of 233 consecutive heart transplant recipients who had baseline, early postoperative and follow-up coronary angiograms, as well as a subset of 47 patients with baseline intracoronary ultrasound imaging recordings, were analyzed (mean 3.8 years of follow-up). Patients were subclassified according to the presence of donor coronary artery disease on the baseline angiogram and stratified at age 40 years.
Results. Patients without evidence of preexisting coronary artery disease on a baseline angiogram (n = 219) were significantly less likely to develop new disease than the 14 patients with preexisting coronary artery disease (p = 0.002). Although older donors exhibited earlier coronary artery disease than younger donors at 3 years of follow-up, there was no difference by 5 years (p = 0.25). There was no difference in survival or probability of developing ischemic events between the groups. Baseline ultrasound imaging revealed substantial disease in 7 of 9 older donated hearts, and in only 7 of 38 younger donated hearts (p = 0.002). Preexisting coronary artery disease, nonuse of calcium channel blocking agents, older donor age, posttransplantation cytomegalovirus infection, elevated very low density lipoprotein levels and previous ischemic heart disease in the recipient were significant predictors of allograft coronary artery disease.
Conclusions. Heart donors with angiographic evidence of pre-existing coronary artery disease and older donors are more likely to develop new allograft coronary artery disease by 3 years. However, there is no difference in patient survival or freedom from ischemic events between younger and older donors at a mean follow-up of 3.8 years.
(J Am Coll Cardiol 1997;29:623–9)</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9060902</pmid><doi>10.1016/S0735-1097(96)00521-9</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the American College of Cardiology, 1997-03, Vol.29 (3), p.623-629 |
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| subjects | Adolescent Adult Age Factors Biological and medical sciences Coronary Angiography Coronary Disease - diagnostic imaging Coronary Disease - etiology Disease Progression Heart Transplantation Humans Medical sciences Postoperative Complications Retrospective Studies Risk Factors Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Tissue Donors Transplantation, Homologous Ultrasonography, Interventional |
| title | Relation of Donor Age and Preexisting Coronary Artery Disease on Angiography and Intracoronary Ultrasound to Later Development of Accelerated Allograft Coronary Artery Disease |
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