Control of intractable spasticity with intrathecal morphine sulfate
Three years ago we reported our preliminary results regarding treatment of intractable spasticity with use of intrathecal morphine. This paper is a follow-up report of 12 patients who underwent implantation of a pump or reservoir for delivery of intrathecal morphine sulfate for control of spasticity...
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| Veröffentlicht in: | Neurosurgery 1989-02, Vol.24 (2), p.236-238 |
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| container_title | Neurosurgery |
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| creator | ERICKSON, D. L LO, J MICHAELSON, M |
| description | Three years ago we reported our preliminary results regarding treatment of intractable spasticity with use of intrathecal morphine. This paper is a follow-up report of 12 patients who underwent implantation of a pump or reservoir for delivery of intrathecal morphine sulfate for control of spasticity. Our primary concern initially was that patients would ultimately become drug tolerant and lose the beneficial effect of the morphine. Only one of these 12 patients has developed drug tolerance. The longest follow-up period has been 4.3 years, and this patient has maintained excellent control of his spasticity with a stable dose of 2 mg of morphine daily. |
| doi_str_mv | 10.1227/00006123-198902000-00013 |
| format | Article |
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L ; LO, J ; MICHAELSON, M</creator><creatorcontrib>ERICKSON, D. L ; LO, J ; MICHAELSON, M</creatorcontrib><description>Three years ago we reported our preliminary results regarding treatment of intractable spasticity with use of intrathecal morphine. This paper is a follow-up report of 12 patients who underwent implantation of a pump or reservoir for delivery of intrathecal morphine sulfate for control of spasticity. Our primary concern initially was that patients would ultimately become drug tolerant and lose the beneficial effect of the morphine. Only one of these 12 patients has developed drug tolerance. The longest follow-up period has been 4.3 years, and this patient has maintained excellent control of his spasticity with a stable dose of 2 mg of morphine daily.</description><identifier>ISSN: 0148-396X</identifier><identifier>EISSN: 1524-4040</identifier><identifier>DOI: 10.1227/00006123-198902000-00013</identifier><identifier>PMID: 2918974</identifier><identifier>CODEN: NRSRDY</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Analgesics ; Biological and medical sciences ; Drug Tolerance ; Follow-Up Studies ; Humans ; Infusion Pumps ; Injections, Spinal ; Medical sciences ; Morphine - administration & dosage ; Morphine - therapeutic use ; Muscle Spasticity - drug therapy ; Neuropharmacology ; Pharmacology. 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L</creatorcontrib><creatorcontrib>LO, J</creatorcontrib><creatorcontrib>MICHAELSON, M</creatorcontrib><title>Control of intractable spasticity with intrathecal morphine sulfate</title><title>Neurosurgery</title><addtitle>Neurosurgery</addtitle><description>Three years ago we reported our preliminary results regarding treatment of intractable spasticity with use of intrathecal morphine. This paper is a follow-up report of 12 patients who underwent implantation of a pump or reservoir for delivery of intrathecal morphine sulfate for control of spasticity. Our primary concern initially was that patients would ultimately become drug tolerant and lose the beneficial effect of the morphine. Only one of these 12 patients has developed drug tolerance. The longest follow-up period has been 4.3 years, and this patient has maintained excellent control of his spasticity with a stable dose of 2 mg of morphine daily.</description><subject>Analgesics</subject><subject>Biological and medical sciences</subject><subject>Drug Tolerance</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Infusion Pumps</subject><subject>Injections, Spinal</subject><subject>Medical sciences</subject><subject>Morphine - administration & dosage</subject><subject>Morphine - therapeutic use</subject><subject>Muscle Spasticity - drug therapy</subject><subject>Neuropharmacology</subject><subject>Pharmacology. 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| fulltext | fulltext |
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| ispartof | Neurosurgery, 1989-02, Vol.24 (2), p.236-238 |
| issn | 0148-396X 1524-4040 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Analgesics Biological and medical sciences Drug Tolerance Follow-Up Studies Humans Infusion Pumps Injections, Spinal Medical sciences Morphine - administration & dosage Morphine - therapeutic use Muscle Spasticity - drug therapy Neuropharmacology Pharmacology. Drug treatments Time Factors |
| title | Control of intractable spasticity with intrathecal morphine sulfate |
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