Cell Cycle–Dependent Polar Localization of Chromosome Partitioning Proteins in Caulobacter crescentus
In the bacterium C. crescentus, the cellular homologs of plasmid partitioning proteins, ParA and ParB, localize to both poles of the predivisional cell following the completion of DNA replication. ParB binds to DNA sequences adjacent to the origin of replication suggesting that this region of the ge...
Gespeichert in:
Veröffentlicht in: | Cell 1997-03, Vol.88 (5), p.675-684 |
---|---|
Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 684 |
---|---|
container_issue | 5 |
container_start_page | 675 |
container_title | Cell |
container_volume | 88 |
creator | Mohl, Dane A Gober, James W |
description | In the bacterium C. crescentus, the cellular homologs of plasmid partitioning proteins, ParA and ParB, localize to both poles of the predivisional cell following the completion of DNA replication. ParB binds to DNA sequences adjacent to the origin of replication suggesting that this region of the genome is tethered to the poles of the cell at a specific time in the cell cycle. Increasing the cellular levels of ParA and ParB disrupts polar localization and results in defects in both cell division and chromosome partitioning. These results suggest that ParA and ParB are involved in partitioning newly replicated chromosomes to the poles of the predivisional cell and may function as components of a bacterial mitotic apparatus. |
doi_str_mv | 10.1016/S0092-8674(00)81910-8 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78872407</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0092867400819108</els_id><sourcerecordid>78872407</sourcerecordid><originalsourceid>FETCH-LOGICAL-c422t-8bca0f0ea01db88d12892e5caf28906098946ce966a2e6958c7822e3fab1f0a83</originalsourceid><addsrcrecordid>eNqFUU1P3DAQtRBou0B_ApJPFT2kjL1xYp8QCqVFWomVSs-W40zAlRNv7QSJnvgP_EN-SbMf4sppRjNv5j29R8gZg28MWHHxC0DxTBZlfg7wVTLFIJMHZM5AlVnOSn5I5u-QT-Q4pT8AIIUQMzJTIHIB5Zw8VOg9rZ6tx7eX12tcY99gP9BV8CbSZbDGu39mcKGnoaXVYwxdSKFDujJxcJu56x_oKoYBXZ-o62llRh9qYweM1EZMdno3plNy1Bqf8PO-npDfN9_vq5_Z8u7HbXW1zGzO-ZDJ2hpoAQ2wppayYVwqjsKadmqgACVVXlhURWE4FkpIW0rOcdGamrVg5OKEfNn9Xcfwd8Q06M5NErw3PYYx6VLKkudQfghkQrGFkHwCih3QxpBSxFavo-tMfNYM9CYJvU1Cb2zWAHqbhN4oOdsTjHWHzfvV3vppf7nb42THk8Ook3XYW2xcRDvoJrgPGP4DlHSaaw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15913582</pqid></control><display><type>article</type><title>Cell Cycle–Dependent Polar Localization of Chromosome Partitioning Proteins in Caulobacter crescentus</title><source>MEDLINE</source><source>Cell Press Free Archives</source><source>Elsevier ScienceDirect Journals</source><source>EZB Electronic Journals Library</source><creator>Mohl, Dane A ; Gober, James W</creator><creatorcontrib>Mohl, Dane A ; Gober, James W</creatorcontrib><description>In the bacterium C. crescentus, the cellular homologs of plasmid partitioning proteins, ParA and ParB, localize to both poles of the predivisional cell following the completion of DNA replication. ParB binds to DNA sequences adjacent to the origin of replication suggesting that this region of the genome is tethered to the poles of the cell at a specific time in the cell cycle. Increasing the cellular levels of ParA and ParB disrupts polar localization and results in defects in both cell division and chromosome partitioning. These results suggest that ParA and ParB are involved in partitioning newly replicated chromosomes to the poles of the predivisional cell and may function as components of a bacterial mitotic apparatus.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/S0092-8674(00)81910-8</identifier><identifier>PMID: 9054507</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bacterial Proteins - analysis ; Bacterial Proteins - genetics ; Base Sequence ; caulobacter crescentus ; Caulobacter crescentus - chemistry ; Caulobacter crescentus - cytology ; Caulobacter crescentus - genetics ; Cell Cycle - physiology ; Chromosomes, Bacterial - physiology ; Gene Expression Regulation, Bacterial - physiology ; Genes, Bacterial - physiology ; Mitosis - physiology ; Molecular Sequence Data ; Replication Origin - genetics ; Repressor Proteins - genetics ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid</subject><ispartof>Cell, 1997-03, Vol.88 (5), p.675-684</ispartof><rights>1997 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-8bca0f0ea01db88d12892e5caf28906098946ce966a2e6958c7822e3fab1f0a83</citedby><cites>FETCH-LOGICAL-c422t-8bca0f0ea01db88d12892e5caf28906098946ce966a2e6958c7822e3fab1f0a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0092-8674(00)81910-8$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9054507$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohl, Dane A</creatorcontrib><creatorcontrib>Gober, James W</creatorcontrib><title>Cell Cycle–Dependent Polar Localization of Chromosome Partitioning Proteins in Caulobacter crescentus</title><title>Cell</title><addtitle>Cell</addtitle><description>In the bacterium C. crescentus, the cellular homologs of plasmid partitioning proteins, ParA and ParB, localize to both poles of the predivisional cell following the completion of DNA replication. ParB binds to DNA sequences adjacent to the origin of replication suggesting that this region of the genome is tethered to the poles of the cell at a specific time in the cell cycle. Increasing the cellular levels of ParA and ParB disrupts polar localization and results in defects in both cell division and chromosome partitioning. These results suggest that ParA and ParB are involved in partitioning newly replicated chromosomes to the poles of the predivisional cell and may function as components of a bacterial mitotic apparatus.</description><subject>Bacterial Proteins - analysis</subject><subject>Bacterial Proteins - genetics</subject><subject>Base Sequence</subject><subject>caulobacter crescentus</subject><subject>Caulobacter crescentus - chemistry</subject><subject>Caulobacter crescentus - cytology</subject><subject>Caulobacter crescentus - genetics</subject><subject>Cell Cycle - physiology</subject><subject>Chromosomes, Bacterial - physiology</subject><subject>Gene Expression Regulation, Bacterial - physiology</subject><subject>Genes, Bacterial - physiology</subject><subject>Mitosis - physiology</subject><subject>Molecular Sequence Data</subject><subject>Replication Origin - genetics</subject><subject>Repressor Proteins - genetics</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1P3DAQtRBou0B_ApJPFT2kjL1xYp8QCqVFWomVSs-W40zAlRNv7QSJnvgP_EN-SbMf4sppRjNv5j29R8gZg28MWHHxC0DxTBZlfg7wVTLFIJMHZM5AlVnOSn5I5u-QT-Q4pT8AIIUQMzJTIHIB5Zw8VOg9rZ6tx7eX12tcY99gP9BV8CbSZbDGu39mcKGnoaXVYwxdSKFDujJxcJu56x_oKoYBXZ-o62llRh9qYweM1EZMdno3plNy1Bqf8PO-npDfN9_vq5_Z8u7HbXW1zGzO-ZDJ2hpoAQ2wppayYVwqjsKadmqgACVVXlhURWE4FkpIW0rOcdGamrVg5OKEfNn9Xcfwd8Q06M5NErw3PYYx6VLKkudQfghkQrGFkHwCih3QxpBSxFavo-tMfNYM9CYJvU1Cb2zWAHqbhN4oOdsTjHWHzfvV3vppf7nb42THk8Ook3XYW2xcRDvoJrgPGP4DlHSaaw</recordid><startdate>19970307</startdate><enddate>19970307</enddate><creator>Mohl, Dane A</creator><creator>Gober, James W</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19970307</creationdate><title>Cell Cycle–Dependent Polar Localization of Chromosome Partitioning Proteins in Caulobacter crescentus</title><author>Mohl, Dane A ; Gober, James W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-8bca0f0ea01db88d12892e5caf28906098946ce966a2e6958c7822e3fab1f0a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Bacterial Proteins - analysis</topic><topic>Bacterial Proteins - genetics</topic><topic>Base Sequence</topic><topic>caulobacter crescentus</topic><topic>Caulobacter crescentus - chemistry</topic><topic>Caulobacter crescentus - cytology</topic><topic>Caulobacter crescentus - genetics</topic><topic>Cell Cycle - physiology</topic><topic>Chromosomes, Bacterial - physiology</topic><topic>Gene Expression Regulation, Bacterial - physiology</topic><topic>Genes, Bacterial - physiology</topic><topic>Mitosis - physiology</topic><topic>Molecular Sequence Data</topic><topic>Replication Origin - genetics</topic><topic>Repressor Proteins - genetics</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohl, Dane A</creatorcontrib><creatorcontrib>Gober, James W</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohl, Dane A</au><au>Gober, James W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell Cycle–Dependent Polar Localization of Chromosome Partitioning Proteins in Caulobacter crescentus</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1997-03-07</date><risdate>1997</risdate><volume>88</volume><issue>5</issue><spage>675</spage><epage>684</epage><pages>675-684</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>In the bacterium C. crescentus, the cellular homologs of plasmid partitioning proteins, ParA and ParB, localize to both poles of the predivisional cell following the completion of DNA replication. ParB binds to DNA sequences adjacent to the origin of replication suggesting that this region of the genome is tethered to the poles of the cell at a specific time in the cell cycle. Increasing the cellular levels of ParA and ParB disrupts polar localization and results in defects in both cell division and chromosome partitioning. These results suggest that ParA and ParB are involved in partitioning newly replicated chromosomes to the poles of the predivisional cell and may function as components of a bacterial mitotic apparatus.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>9054507</pmid><doi>10.1016/S0092-8674(00)81910-8</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0092-8674 |
ispartof | Cell, 1997-03, Vol.88 (5), p.675-684 |
issn | 0092-8674 1097-4172 |
language | eng |
recordid | cdi_proquest_miscellaneous_78872407 |
source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB Electronic Journals Library |
subjects | Bacterial Proteins - analysis Bacterial Proteins - genetics Base Sequence caulobacter crescentus Caulobacter crescentus - chemistry Caulobacter crescentus - cytology Caulobacter crescentus - genetics Cell Cycle - physiology Chromosomes, Bacterial - physiology Gene Expression Regulation, Bacterial - physiology Genes, Bacterial - physiology Mitosis - physiology Molecular Sequence Data Replication Origin - genetics Repressor Proteins - genetics Sequence Analysis, DNA Sequence Homology, Amino Acid |
title | Cell Cycle–Dependent Polar Localization of Chromosome Partitioning Proteins in Caulobacter crescentus |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T19%3A45%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cell%20Cycle%E2%80%93Dependent%20Polar%20Localization%20of%20Chromosome%20Partitioning%20Proteins%20in%20Caulobacter%20crescentus&rft.jtitle=Cell&rft.au=Mohl,%20Dane%20A&rft.date=1997-03-07&rft.volume=88&rft.issue=5&rft.spage=675&rft.epage=684&rft.pages=675-684&rft.issn=0092-8674&rft.eissn=1097-4172&rft_id=info:doi/10.1016/S0092-8674(00)81910-8&rft_dat=%3Cproquest_cross%3E78872407%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15913582&rft_id=info:pmid/9054507&rft_els_id=S0092867400819108&rfr_iscdi=true |