Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs
Recently, an acute phase (AP) protein response has been reported in major depression. In order to examine whether an AP response occurs in other psychiatric disorders, such as schizophrenia and mania, the authors measured plasma AP reactants, such as haptoglobin (Hp), immunoglobulin G (IgG), IgM, fi...
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Veröffentlicht in: | Psychiatry research 1997-01, Vol.66 (1), p.1-11 |
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description | Recently, an acute phase (AP) protein response has been reported in major depression. In order to examine whether an AP response occurs in other psychiatric disorders, such as schizophrenia and mania, the authors measured plasma AP reactants, such as haptoglobin (Hp), immunoglobulin G (IgG), IgM, fibrinogen (Fb), complement component 3 (C3C), C4,
α
1-antitrypsin (
α
1AT),
α
1-acid-glycoprotein (
α
1S) and hemopexin (Hpx), in 27 schizophrenic, 23 manic, 29 major depressed and 21 normal subjects. Schizophrenic patients had significantly higher plasma Hp, Fb, C3C, C4,
α
1S and Hpx than normal controls. Manic subjects showed significantly higher plasma Hp, Fb,
α
1S and Hpx than normal volunteers. Depressed subjects had significantly higher plasma Hp, Fb, C3C, C4 and
α
1S than normal controls. Overall, the above disorders in AP reactants were more pronounced in schizophrenic than in depressed subjects. No significant differences in the above AP reactants could be found between normal volunteers, and schizophrenic, manic or depressed patients who underwent chronic treatment with psychotropic drugs. Plasma Hp, Fb, C3C, C4,
α
1S, and Hpx were significantly higher in schizophrenic, manic and depressed patients who were non-medicated than in those who were treated with antidepressants, antipsychotics or lithium. The results suggest that not only major depression but also schizophrenia and mania are accompanied by an AP response, and that the latter may be suppressed by (sub)chronic treatment with psychotropic drugs. |
doi_str_mv | 10.1016/S0165-1781(96)02915-0 |
format | Article |
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α
1-antitrypsin (
α
1AT),
α
1-acid-glycoprotein (
α
1S) and hemopexin (Hpx), in 27 schizophrenic, 23 manic, 29 major depressed and 21 normal subjects. Schizophrenic patients had significantly higher plasma Hp, Fb, C3C, C4,
α
1S and Hpx than normal controls. Manic subjects showed significantly higher plasma Hp, Fb,
α
1S and Hpx than normal volunteers. Depressed subjects had significantly higher plasma Hp, Fb, C3C, C4 and
α
1S than normal controls. Overall, the above disorders in AP reactants were more pronounced in schizophrenic than in depressed subjects. No significant differences in the above AP reactants could be found between normal volunteers, and schizophrenic, manic or depressed patients who underwent chronic treatment with psychotropic drugs. Plasma Hp, Fb, C3C, C4,
α
1S, and Hpx were significantly higher in schizophrenic, manic and depressed patients who were non-medicated than in those who were treated with antidepressants, antipsychotics or lithium. The results suggest that not only major depression but also schizophrenia and mania are accompanied by an AP response, and that the latter may be suppressed by (sub)chronic treatment with psychotropic drugs.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/S0165-1781(96)02915-0</identifier><identifier>PMID: 9061799</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acute phase response ; Acute-Phase Proteins - analysis ; Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Bipolar Disorder - blood ; Bipolar Disorder - drug therapy ; Cytokines ; Cytokines - biosynthesis ; Depression ; Depressive Disorder - blood ; Depressive Disorder - drug therapy ; Female ; Humans ; Immune disorders ; Male ; Mania ; Medical sciences ; Middle Aged ; Phenotype ; Plasma - chemistry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Psychotropic Drugs - pharmacology ; Psychotropic Drugs - therapeutic use ; Schizophrenia ; Schizophrenia - blood ; Schizophrenia - drug therapy</subject><ispartof>Psychiatry research, 1997-01, Vol.66 (1), p.1-11</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-f88a4b2c7c2518d14e9e04c4186e374463070345628e04556e694de02f89f0d43</citedby><cites>FETCH-LOGICAL-c507t-f88a4b2c7c2518d14e9e04c4186e374463070345628e04556e694de02f89f0d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0165-1781(96)02915-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2599675$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9061799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maes, Michael</creatorcontrib><creatorcontrib>Delange, Joris</creatorcontrib><creatorcontrib>Ranjan, Rakesch</creatorcontrib><creatorcontrib>Meltzer, Herbert Y.</creatorcontrib><creatorcontrib>Desnyder, Roger</creatorcontrib><creatorcontrib>Cooremans, Walter</creatorcontrib><creatorcontrib>Scharpé, Simon</creatorcontrib><title>Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Recently, an acute phase (AP) protein response has been reported in major depression. In order to examine whether an AP response occurs in other psychiatric disorders, such as schizophrenia and mania, the authors measured plasma AP reactants, such as haptoglobin (Hp), immunoglobulin G (IgG), IgM, fibrinogen (Fb), complement component 3 (C3C), C4,
α
1-antitrypsin (
α
1AT),
α
1-acid-glycoprotein (
α
1S) and hemopexin (Hpx), in 27 schizophrenic, 23 manic, 29 major depressed and 21 normal subjects. Schizophrenic patients had significantly higher plasma Hp, Fb, C3C, C4,
α
1S and Hpx than normal controls. Manic subjects showed significantly higher plasma Hp, Fb,
α
1S and Hpx than normal volunteers. Depressed subjects had significantly higher plasma Hp, Fb, C3C, C4 and
α
1S than normal controls. Overall, the above disorders in AP reactants were more pronounced in schizophrenic than in depressed subjects. No significant differences in the above AP reactants could be found between normal volunteers, and schizophrenic, manic or depressed patients who underwent chronic treatment with psychotropic drugs. Plasma Hp, Fb, C3C, C4,
α
1S, and Hpx were significantly higher in schizophrenic, manic and depressed patients who were non-medicated than in those who were treated with antidepressants, antipsychotics or lithium. The results suggest that not only major depression but also schizophrenia and mania are accompanied by an AP response, and that the latter may be suppressed by (sub)chronic treatment with psychotropic drugs.</description><subject>Acute phase response</subject><subject>Acute-Phase Proteins - analysis</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Bipolar Disorder - blood</subject><subject>Bipolar Disorder - drug therapy</subject><subject>Cytokines</subject><subject>Cytokines - biosynthesis</subject><subject>Depression</subject><subject>Depressive Disorder - blood</subject><subject>Depressive Disorder - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Immune disorders</subject><subject>Male</subject><subject>Mania</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Phenotype</subject><subject>Plasma - chemistry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Psychotropic Drugs - pharmacology</subject><subject>Psychotropic Drugs - therapeutic use</subject><subject>Schizophrenia</subject><subject>Schizophrenia - blood</subject><subject>Schizophrenia - drug therapy</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEuLFDEQgIMo67j6ExZyEFGwNenOcy-yLL5gwYN6Dpmk2snS3WlT3cL4683sDHP1UlWkvqokHyFXnL3jjKv332uQDdeGv7bqDWstlw17RDbc6LbRvO0ek80ZeUqeId4zxlpu7QW5sExxbe2GhJuwLkDnnccaS14gTUjTRDHs0t887wpMyb-lo6-J-inW6j4XGmEugJjydE3HHNfBL7Wm2z2dcR92eSl5ToHGsv7C5-RJ7weEF6d8SX5--vjj9ktz9-3z19ubuyZIppemN8aLbRt0aCU3kQuwwEQQ3CjotBCqY5p1QqrW1HMpFSgrIrC2N7ZnUXSX5NVxb_3H7xVwcWPCAMPgJ8grOm2M5p1lFZRHMJSMWKB3c0mjL3vHmTvIdQ9y3cGcs8o9yHWHuavTBet2hHieOtms_Zenvsfgh774KSQ8Y620VmlZsQ9HDKqMPwmKw5BgChBTgbC4mNN_HvIPdFuWIw</recordid><startdate>19970115</startdate><enddate>19970115</enddate><creator>Maes, Michael</creator><creator>Delange, Joris</creator><creator>Ranjan, Rakesch</creator><creator>Meltzer, Herbert Y.</creator><creator>Desnyder, Roger</creator><creator>Cooremans, Walter</creator><creator>Scharpé, Simon</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970115</creationdate><title>Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs</title><author>Maes, Michael ; Delange, Joris ; Ranjan, Rakesch ; Meltzer, Herbert Y. ; Desnyder, Roger ; Cooremans, Walter ; Scharpé, Simon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-f88a4b2c7c2518d14e9e04c4186e374463070345628e04556e694de02f89f0d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acute phase response</topic><topic>Acute-Phase Proteins - analysis</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Bipolar Disorder - blood</topic><topic>Bipolar Disorder - drug therapy</topic><topic>Cytokines</topic><topic>Cytokines - biosynthesis</topic><topic>Depression</topic><topic>Depressive Disorder - blood</topic><topic>Depressive Disorder - drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Immune disorders</topic><topic>Male</topic><topic>Mania</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Phenotype</topic><topic>Plasma - chemistry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Psychotropic Drugs - pharmacology</topic><topic>Psychotropic Drugs - therapeutic use</topic><topic>Schizophrenia</topic><topic>Schizophrenia - blood</topic><topic>Schizophrenia - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maes, Michael</creatorcontrib><creatorcontrib>Delange, Joris</creatorcontrib><creatorcontrib>Ranjan, Rakesch</creatorcontrib><creatorcontrib>Meltzer, Herbert Y.</creatorcontrib><creatorcontrib>Desnyder, Roger</creatorcontrib><creatorcontrib>Cooremans, Walter</creatorcontrib><creatorcontrib>Scharpé, Simon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maes, Michael</au><au>Delange, Joris</au><au>Ranjan, Rakesch</au><au>Meltzer, Herbert Y.</au><au>Desnyder, Roger</au><au>Cooremans, Walter</au><au>Scharpé, Simon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>1997-01-15</date><risdate>1997</risdate><volume>66</volume><issue>1</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>Recently, an acute phase (AP) protein response has been reported in major depression. In order to examine whether an AP response occurs in other psychiatric disorders, such as schizophrenia and mania, the authors measured plasma AP reactants, such as haptoglobin (Hp), immunoglobulin G (IgG), IgM, fibrinogen (Fb), complement component 3 (C3C), C4,
α
1-antitrypsin (
α
1AT),
α
1-acid-glycoprotein (
α
1S) and hemopexin (Hpx), in 27 schizophrenic, 23 manic, 29 major depressed and 21 normal subjects. Schizophrenic patients had significantly higher plasma Hp, Fb, C3C, C4,
α
1S and Hpx than normal controls. Manic subjects showed significantly higher plasma Hp, Fb,
α
1S and Hpx than normal volunteers. Depressed subjects had significantly higher plasma Hp, Fb, C3C, C4 and
α
1S than normal controls. Overall, the above disorders in AP reactants were more pronounced in schizophrenic than in depressed subjects. No significant differences in the above AP reactants could be found between normal volunteers, and schizophrenic, manic or depressed patients who underwent chronic treatment with psychotropic drugs. Plasma Hp, Fb, C3C, C4,
α
1S, and Hpx were significantly higher in schizophrenic, manic and depressed patients who were non-medicated than in those who were treated with antidepressants, antipsychotics or lithium. The results suggest that not only major depression but also schizophrenia and mania are accompanied by an AP response, and that the latter may be suppressed by (sub)chronic treatment with psychotropic drugs.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>9061799</pmid><doi>10.1016/S0165-1781(96)02915-0</doi><tpages>11</tpages></addata></record> |
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subjects | Acute phase response Acute-Phase Proteins - analysis Adult Adult and adolescent clinical studies Biological and medical sciences Bipolar Disorder - blood Bipolar Disorder - drug therapy Cytokines Cytokines - biosynthesis Depression Depressive Disorder - blood Depressive Disorder - drug therapy Female Humans Immune disorders Male Mania Medical sciences Middle Aged Phenotype Plasma - chemistry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Psychotropic Drugs - pharmacology Psychotropic Drugs - therapeutic use Schizophrenia Schizophrenia - blood Schizophrenia - drug therapy |
title | Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs |
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