Investigations of the Mechanism of the Positive Inotropic Action of BDF 9148: Comparison with DPI 201-106 and the Enantiomers

The electromechanical and biochemical activities of the positive inotropic compounds BDF 9148 and DPI 201-106 were compared in guinea-pig myocardic preparations. Additionally, the properties of the BDF 9148 enantiomers were studied to compare their positive inotropic effects. In guinea pig papillary...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1997-02, Vol.29 (2), p.164-173
Hauptverfasser:	Raap, Achim, Armah, Benjamin, Mest, Hans-Jürgen, Stenzel, Wolfgang, Schloos, Jürgen, Blechacz, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azetidines - pharmacology Biological and medical sciences Cardiotonic agents Cardiotonic Agents - pharmacology Cardiovascular system Cyclic AMP - metabolism Guinea Pigs Heart Rate - drug effects In Vitro Techniques Male Medical sciences Myocardial Contraction - drug effects Papillary Muscles - drug effects Papillary Muscles - physiology Pharmacology. Drug treatments Piperazines - pharmacology Rats Sodium-Potassium-Exchanging ATPase - drug effects Stereoisomerism
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