The relationship between chromosome structure and function at a human telomeric region

We have sequenced a contiguous 284,495-bp segment of DNA extending from the terminal (TTAGGG)n repeats of the short arm of chromosome 16, providing a full description of the transition from telomeric through subtelomeric DNA to sequences that are unique to the chromosome. To complement and extend an...

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Veröffentlicht in:	Nature genetics 1997-03, Vol.15 (3), p.252-257
Hauptverfasser:	Flint, Jonathan, Thomas, Karen, Micklem, Gos, Raynham, Helen, Clark, Kevin, Doggett, Norman A, Andrew, Andrew, Higgs, Douglas R
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Chromosome Mapping Chromosomes, Human, Pair 16 Classical genetics, quantitative genetics, hybrids Deoxyribonuclease I Dinucleotide Repeats DNA - chemistry DNA - genetics Fundamental and applied biological sciences. Psychology Genetic Markers Genetics of eukaryotes. Biological and molecular evolution Human Humans Minisatellite Repeats Molecular Sequence Data Polymerase Chain Reaction Repetitive Sequences, Nucleic Acid RNA, Messenger - biosynthesis Telomere Transcription, Genetic
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Beschreibung
Zusammenfassung:	We have sequenced a contiguous 284,495-bp segment of DNA extending from the terminal (TTAGGG)n repeats of the short arm of chromosome 16, providing a full description of the transition from telomeric through subtelomeric DNA to sequences that are unique to the chromosome. To complement and extend analysis of the primary sequence, we have characterized mRNA transcripts, patterns of DNA methylation and DNase I sensitivity. Together with previous data these studies describe in detail the structural and functional organization of a human telomeric region.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/ng0397-252