EFFECT OF ORAL DOXAPRAM ON MORPHINE-INDUCED CHANGES IN THE VENTILATORY RESPONSE TO CARBON DIOXIDE
A double-blind crossover volunteer trial has been carried out to determine if oral doxapram reduces the respiratory depression caused by morphine 0.12 mg kg−1 i.m. Doxapram was given to the subjects 90 min before the morphine and significantly reduced the displacement of the ventilatory response to...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1989-02, Vol.62 (2), p.159-163 |
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| container_title | British journal of anaesthesia : BJA |
| container_volume | 62 |
| creator | RANDALL, N.P.C. PLEUVRY, B.J. FAZACKERLEY, E.J. MODLA, C.Y. PRESCOTT, L.F. HEALY, T.E.J. |
| description | A double-blind crossover volunteer trial has been carried out to determine if oral doxapram reduces the respiratory depression caused by morphine 0.12 mg kg−1 i.m. Doxapram was given to the subjects 90 min before the morphine and significantly reduced the displacement of the ventilatory response to carbon dioxide caused by the morphine. This occurred despite the fact that the plasma concentrations of doxapram were significantly lower when the subject had been given morphine than when a placebo injection had been administered. Doxapram alone in doses of 300 mg and 600 mg did not alter significantly the respiratory variables measured in this study. |
| doi_str_mv | 10.1093/bja/62.2.159 |
| format | Article |
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Doxapram was given to the subjects 90 min before the morphine and significantly reduced the displacement of the ventilatory response to carbon dioxide caused by the morphine. This occurred despite the fact that the plasma concentrations of doxapram were significantly lower when the subject had been given morphine than when a placebo injection had been administered. Doxapram alone in doses of 300 mg and 600 mg did not alter significantly the respiratory variables measured in this study.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/62.2.159</identifier><identifier>PMID: 2493800</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Administration, Oral ; Adult ; Biological and medical sciences ; Carbon Dioxide - physiology ; Depression, Chemical ; Doxapram - administration & dosage ; Doxapram - blood ; Doxapram - pharmacology ; Female ; Humans ; Male ; Medical sciences ; Morphine - pharmacology ; Pharmacology. 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Doxapram was given to the subjects 90 min before the morphine and significantly reduced the displacement of the ventilatory response to carbon dioxide caused by the morphine. This occurred despite the fact that the plasma concentrations of doxapram were significantly lower when the subject had been given morphine than when a placebo injection had been administered. Doxapram alone in doses of 300 mg and 600 mg did not alter significantly the respiratory variables measured in this study.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Carbon Dioxide - physiology</subject><subject>Depression, Chemical</subject><subject>Doxapram - administration & dosage</subject><subject>Doxapram - blood</subject><subject>Doxapram - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Morphine - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Respiration - drug effects</subject><subject>Respiratory system</subject><subject>Time Factors</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0M9v0zAUB3BrAo1ucOOK5APitHS249jxMUucJqiLqzSbChfLdRwpoz9G3CL47wlq1ROnd_h-3tPTF4CPGE0xEuH9-sXcMzIlUxyJKzDBlOOAcY7fgAlCiAdIYPIO3Hj_ghDmRETX4JpQEcYITYCReS7TBqocqjqZw0ytkkWdPEJVwUdVL4qykkFZZU-pzGBaJNVMLmFZwaaQ8FlWTTlPGlV_g7VcLlS1lLBRME3qh3E9K9WqzOR78LYzG-8-nOcteMplkxbBXM3KNJkHlobxIRBcRB3FtI0EZkSEbWeiuCM8pBEnDrk1aw2jIUVWxIy21BHDCbWMY9NiG6HwFnw53X0d9j-Pzh_0tvfWbTZm5_ZHr3kcszjm0QjvTtAOe-8H1-nXod-a4Y_GSP9rVI-NakY00WOjI_90vntcb117wecKx_zzOTfemk03mJ3t_YVxjFjI2ciCE-v9wf2-xGb4oRkPeaSL1Xf9NcZFnbOZfhg9O3k3dvard4P2tnc769p-cPag233__3__AjuylZE</recordid><startdate>19890201</startdate><enddate>19890201</enddate><creator>RANDALL, N.P.C.</creator><creator>PLEUVRY, B.J.</creator><creator>FAZACKERLEY, E.J.</creator><creator>MODLA, C.Y.</creator><creator>PRESCOTT, L.F.</creator><creator>HEALY, T.E.J.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890201</creationdate><title>EFFECT OF ORAL DOXAPRAM ON MORPHINE-INDUCED CHANGES IN THE VENTILATORY RESPONSE TO CARBON DIOXIDE</title><author>RANDALL, N.P.C. ; PLEUVRY, B.J. ; FAZACKERLEY, E.J. ; MODLA, C.Y. ; PRESCOTT, L.F. ; HEALY, T.E.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-9795f414d5916293dfa58f2734572e0eb6da64340c9864d4e2a724c671ad1c503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Carbon Dioxide - physiology</topic><topic>Depression, Chemical</topic><topic>Doxapram - administration & dosage</topic><topic>Doxapram - blood</topic><topic>Doxapram - pharmacology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Morphine - pharmacology</topic><topic>Pharmacology. 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| fulltext | fulltext |
| identifier | ISSN: 0007-0912 |
| ispartof | British journal of anaesthesia : BJA, 1989-02, Vol.62 (2), p.159-163 |
| issn | 0007-0912 1471-6771 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78868875 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Administration, Oral Adult Biological and medical sciences Carbon Dioxide - physiology Depression, Chemical Doxapram - administration & dosage Doxapram - blood Doxapram - pharmacology Female Humans Male Medical sciences Morphine - pharmacology Pharmacology. Drug treatments Respiration - drug effects Respiratory system Time Factors |
| title | EFFECT OF ORAL DOXAPRAM ON MORPHINE-INDUCED CHANGES IN THE VENTILATORY RESPONSE TO CARBON DIOXIDE |
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