Phosphodiesterase Inhibitors Prevent Endothelin-1-Induced Vasoconstriction, Bronchoconstriction, and Thromboxane Release in Perfused Rat Lung

Endothelin-1 (ET-1) causes broncho- and vasoconstriction in the rat isolated perfused lung and induces the release of thromboxane and prostacyclin. Pharmacological inhibition of phosphodiesterases (PDE) is known to relax airway and vascular smooth muscle and it attenuates the release of pro-inflamma...

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