Conversion of highly malignant colon cancer from an aggressive to a controlled disease by oral administration of a metalloproteinase inhibitor

In this study, we describe the activity of CT1746, an orally-active synthetic MMP inhibitor that has a greater specificity for gelatinase A, gelatinase B and stromelysin than for interstitial collagenase and matrilysin, in a nude mouse model that better mimics the clinical development of human colon...

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Veröffentlicht in:	Clinical & experimental metastasis 1997-03, Vol.15 (2), p.184-195
Hauptverfasser:	An, Z, Wang, X, Willmott, N, Chander, S K, Tickle, S, Docherty, A J, Mountain, A, Millican, A T, Morphy, R, Porter, J R, Epemolu, R O, Kubota, T, Moossa, A R, Hoffman, R M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - therapeutic use Animals Antineoplastic Agents - therapeutic use Colonic Neoplasms - drug therapy Colonic Neoplasms - enzymology Colonic Neoplasms - pathology Drug Screening Assays, Antitumor Humans Male Metalloendopeptidases - antagonists & inhibitors Mice Mice, Nude Neoplasm Proteins - antagonists & inhibitors Transplantation, Heterologous
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