The human obesity gene map: the 1996 update
An update of the human obesity gene map up to October 1996 is presented. Evidence from Mendelian disorders exhibiting obesity as a clinical feature, single-gene mutation rodent models, quantitative trait loci uncovered in crossbreeding experiments with mouse, rat, and pig models, association and cas...
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| Veröffentlicht in: | Obesity research 1997-01, Vol.5 (1), p.49-61 |
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| creator | Perusse, L. (Laval University, Ste-Foy, Quebec, Canada.) Chagnon, Y.C Dionne, F.T Bouchard, C |
| description | An update of the human obesity gene map up to October 1996 is presented. Evidence from Mendelian disorders exhibiting obesity as a clinical feature, single-gene mutation rodent models, quantitative trait loci uncovered in crossbreeding experiments with mouse, rat, and pig models, association and case-control studies with candidate genes, and linkage studies with genes and other markers is reviewed. All chromosomal locations of the animal loci are converted into human genome locations based on syntenic relationships between the genomes. A complete listing of all these loci reveals that only 4 of the 24 human chromosomes are not yet represented, i.e., 9, 18, 21, and Y. Several chromosome arms are characterized by the presence of several putative loci. The following arms include at least three such loci: 1p, 1q, 3p, 4q, 6p, 7q, 8p, 8q, 11p, 11q, 15q, 20q, and Xq. Studies with negative association and linkage results are also reviewed |
| doi_str_mv | 10.1002/j.1550-8528.1997.tb00283.x |
| format | Article |
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(Laval University, Ste-Foy, Quebec, Canada.) ; Chagnon, Y.C ; Dionne, F.T ; Bouchard, C</creator><creatorcontrib>Perusse, L. (Laval University, Ste-Foy, Quebec, Canada.) ; Chagnon, Y.C ; Dionne, F.T ; Bouchard, C</creatorcontrib><description>An update of the human obesity gene map up to October 1996 is presented. Evidence from Mendelian disorders exhibiting obesity as a clinical feature, single-gene mutation rodent models, quantitative trait loci uncovered in crossbreeding experiments with mouse, rat, and pig models, association and case-control studies with candidate genes, and linkage studies with genes and other markers is reviewed. All chromosomal locations of the animal loci are converted into human genome locations based on syntenic relationships between the genomes. A complete listing of all these loci reveals that only 4 of the 24 human chromosomes are not yet represented, i.e., 9, 18, 21, and Y. Several chromosome arms are characterized by the presence of several putative loci. The following arms include at least three such loci: 1p, 1q, 3p, 4q, 6p, 7q, 8p, 8q, 11p, 11q, 15q, 20q, and Xq. 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(Laval University, Ste-Foy, Quebec, Canada.)</creatorcontrib><creatorcontrib>Chagnon, Y.C</creatorcontrib><creatorcontrib>Dionne, F.T</creatorcontrib><creatorcontrib>Bouchard, C</creatorcontrib><title>The human obesity gene map: the 1996 update</title><title>Obesity research</title><addtitle>Obes Res</addtitle><description>An update of the human obesity gene map up to October 1996 is presented. Evidence from Mendelian disorders exhibiting obesity as a clinical feature, single-gene mutation rodent models, quantitative trait loci uncovered in crossbreeding experiments with mouse, rat, and pig models, association and case-control studies with candidate genes, and linkage studies with genes and other markers is reviewed. All chromosomal locations of the animal loci are converted into human genome locations based on syntenic relationships between the genomes. A complete listing of all these loci reveals that only 4 of the 24 human chromosomes are not yet represented, i.e., 9, 18, 21, and Y. Several chromosome arms are characterized by the presence of several putative loci. The following arms include at least three such loci: 1p, 1q, 3p, 4q, 6p, 7q, 8p, 8q, 11p, 11q, 15q, 20q, and Xq. Studies with negative association and linkage results are also reviewed</description><subject>animal models</subject><subject>Animals</subject><subject>association</subject><subject>Chromosome Mapping</subject><subject>FENOTIPOS</subject><subject>GENE</subject><subject>GENERO HUMANO</subject><subject>GENES</subject><subject>Genetic Linkage</subject><subject>GENRE HUMAIN</subject><subject>Humans</subject><subject>linkage</subject><subject>LOCALISATION DE GENE</subject><subject>LOCALIZACION DE GENES</subject><subject>LOCI</subject><subject>LOCUS</subject><subject>mapping</subject><subject>MARCADORES GENETICOS</subject><subject>MARQUEUR GENETIQUE</subject><subject>Mendelian disorders</subject><subject>Mice</subject><subject>MODELE ANIMAL</subject><subject>MODELOS ANIMALES</subject><subject>Mutation</subject><subject>obesity</subject><subject>Obesity - genetics</subject><subject>PHENOTYPE</subject><subject>Rats</subject><subject>SOBREPESO</subject><subject>SURPOIDS</subject><subject>TEJIDO ADIPOSO</subject><subject>TISSU ADIPEUX</subject><subject>TRASTORNOS GENETICOS</subject><subject>TROUBLE GENETIQUE</subject><issn>1071-7323</issn><issn>1550-8528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkM1LwzAchoMoc07_AUEoHrxIa9I0XzsMdPgFgx3cDp5CmqZbR7vWpsXtvzelZXdP-ZH39z4hDwD3CAYIwvBpFyBCoM9JyAMkBAua2F1zHBzOwPgUnbsZMuQzHOJLcGXtDkJEI45GYCQgRQzRMXhcbY23bQu198rY2Kw5ehuzN16hqqnXuMzxqddWiWrMNbhIVW7NzXBOwPrtdTX_8BfL98_588LXBFLsKxGlNOYkSTEUChKjk0SoONKIaiwERymFhlIWChIj5ioR4QIjjSnXCJsQT8BDz63q8qc1tpFFZrXJc7U3ZWsl45wSJohbnPaLui6trU0qqzorVH2UCMrOlNzJTofsdMjOlBxMyYMr3w2vtHFhklN1UOPyWZ__Zrk5_oMsly_fbnCA2x6QqlKqTZ1Zuf4S7ts0FPgPNl19hw</recordid><startdate>199701</startdate><enddate>199701</enddate><creator>Perusse, L. (Laval University, Ste-Foy, Quebec, Canada.)</creator><creator>Chagnon, Y.C</creator><creator>Dionne, F.T</creator><creator>Bouchard, C</creator><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199701</creationdate><title>The human obesity gene map: the 1996 update</title><author>Perusse, L. (Laval University, Ste-Foy, Quebec, Canada.) ; Chagnon, Y.C ; Dionne, F.T ; Bouchard, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5063-a94f6b85df309a05ecdd9ab4c16c39981f60e667295b17506458931c368c13e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>animal models</topic><topic>Animals</topic><topic>association</topic><topic>Chromosome Mapping</topic><topic>FENOTIPOS</topic><topic>GENE</topic><topic>GENERO HUMANO</topic><topic>GENES</topic><topic>Genetic Linkage</topic><topic>GENRE HUMAIN</topic><topic>Humans</topic><topic>linkage</topic><topic>LOCALISATION DE GENE</topic><topic>LOCALIZACION DE GENES</topic><topic>LOCI</topic><topic>LOCUS</topic><topic>mapping</topic><topic>MARCADORES GENETICOS</topic><topic>MARQUEUR GENETIQUE</topic><topic>Mendelian disorders</topic><topic>Mice</topic><topic>MODELE ANIMAL</topic><topic>MODELOS ANIMALES</topic><topic>Mutation</topic><topic>obesity</topic><topic>Obesity - genetics</topic><topic>PHENOTYPE</topic><topic>Rats</topic><topic>SOBREPESO</topic><topic>SURPOIDS</topic><topic>TEJIDO ADIPOSO</topic><topic>TISSU ADIPEUX</topic><topic>TRASTORNOS GENETICOS</topic><topic>TROUBLE GENETIQUE</topic><toplevel>online_resources</toplevel><creatorcontrib>Perusse, L. (Laval University, Ste-Foy, Quebec, Canada.)</creatorcontrib><creatorcontrib>Chagnon, Y.C</creatorcontrib><creatorcontrib>Dionne, F.T</creatorcontrib><creatorcontrib>Bouchard, C</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perusse, L. (Laval University, Ste-Foy, Quebec, Canada.)</au><au>Chagnon, Y.C</au><au>Dionne, F.T</au><au>Bouchard, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The human obesity gene map: the 1996 update</atitle><jtitle>Obesity research</jtitle><addtitle>Obes Res</addtitle><date>1997-01</date><risdate>1997</risdate><volume>5</volume><issue>1</issue><spage>49</spage><epage>61</epage><pages>49-61</pages><issn>1071-7323</issn><eissn>1550-8528</eissn><abstract>An update of the human obesity gene map up to October 1996 is presented. Evidence from Mendelian disorders exhibiting obesity as a clinical feature, single-gene mutation rodent models, quantitative trait loci uncovered in crossbreeding experiments with mouse, rat, and pig models, association and case-control studies with candidate genes, and linkage studies with genes and other markers is reviewed. All chromosomal locations of the animal loci are converted into human genome locations based on syntenic relationships between the genomes. A complete listing of all these loci reveals that only 4 of the 24 human chromosomes are not yet represented, i.e., 9, 18, 21, and Y. Several chromosome arms are characterized by the presence of several putative loci. The following arms include at least three such loci: 1p, 1q, 3p, 4q, 6p, 7q, 8p, 8q, 11p, 11q, 15q, 20q, and Xq. Studies with negative association and linkage results are also reviewed</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9061716</pmid><doi>10.1002/j.1550-8528.1997.tb00283.x</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content |
| subjects | animal models Animals association Chromosome Mapping FENOTIPOS GENE GENERO HUMANO GENES Genetic Linkage GENRE HUMAIN Humans linkage LOCALISATION DE GENE LOCALIZACION DE GENES LOCI LOCUS mapping MARCADORES GENETICOS MARQUEUR GENETIQUE Mendelian disorders Mice MODELE ANIMAL MODELOS ANIMALES Mutation obesity Obesity - genetics PHENOTYPE Rats SOBREPESO SURPOIDS TEJIDO ADIPOSO TISSU ADIPEUX TRASTORNOS GENETICOS TROUBLE GENETIQUE |
| title | The human obesity gene map: the 1996 update |
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