The effect of fatty acids on the vulnerability of lymphocytes to cortisol
We have shown previously that cortisol-sensitive lymphocytes (thymocytes) have a much lower capacity than cortisolresistant cells to catabolize cortisol and that linoleic acid inhibits the catabolism of cortisol by lymphocytes and modulates the sensitivity of lymphocytes to cortisol. In the present...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 1989-03, Vol.38 (3), p.278-281 |
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| container_title | Metabolism, clinical and experimental |
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| creator | Klein, Ami Bruser, Barbara Malkin, Aaron |
| description | We have shown previously that cortisol-sensitive lymphocytes (thymocytes) have a much lower capacity than cortisolresistant cells to catabolize cortisol and that linoleic acid inhibits the catabolism of cortisol by lymphocytes and modulates the sensitivity of lymphocytes to cortisol. In the present study, we attempted to see whether other fatty acids are inhibitory and if inhibition of cortisol catabolism by lymphocytes indicates a change in resistance of the cells to cortisol. Measuring the effect of fatty acids on cortisol catabolism by lymphocytes indicated that the polyunsaturated fatty acids, linoleate, arachidonate, and eicosapenteenoic, inhibit cortisol catabolism by lymphocytes. Using prostaglandin PGE
2 and indomethacin as a blocker of prostaglandin formation, we observed that the effect of the polyunsaturated fatty acids was not due to the formation of prostaglandins. Examining the effect of fatty acids on the vulnerability of lymphocytes to cortisol, we noted that saturated fatty acids had no significant effect, whereas the aforementioned polyunsaturated fatty acids make lymphocytes more sensitive to cortisol. |
| doi_str_mv | 10.1016/0026-0495(89)90088-7 |
| format | Article |
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2 and indomethacin as a blocker of prostaglandin formation, we observed that the effect of the polyunsaturated fatty acids was not due to the formation of prostaglandins. Examining the effect of fatty acids on the vulnerability of lymphocytes to cortisol, we noted that saturated fatty acids had no significant effect, whereas the aforementioned polyunsaturated fatty acids make lymphocytes more sensitive to cortisol.</description><subject>Adrenals. Interrenals</subject><subject>Adrenocortical hormones. Regulation</subject><subject>Arachidonic Acid</subject><subject>Arachidonic Acids - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Survival - drug effects</subject><subject>Dinoprostone - pharmacology</subject><subject>Drug Resistance</subject><subject>Eicosapentaenoic Acid - pharmacology</subject><subject>Fatty Acids - pharmacology</subject><subject>Fatty Acids, Unsaturated - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hydrocortisone - metabolism</subject><subject>Indomethacin - pharmacology</subject><subject>Linoleic Acid</subject><subject>Linoleic Acids - pharmacology</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - metabolism</subject><subject>Lymphocytes - pathology</subject><subject>Vertebrates: endocrinology</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMotVb_gcIsRHQxmswjyWwEKT4KBTd1HZLMDY1MJzVJC_33pnbo0tVdnO8cLh9C1wQ_EkzoE8YFzXHV1Pe8eWgw5jxnJ2hM6rLIOcX4FI2PyDm6COEbY8wYpyM0KuqSVXU1RrPFEjIwBnTMnMmMjHGXSW3bkLk-iyncbroevFS2sylKTLdbrZdO7yKELLpMOx9tcN0lOjOyC3A13An6entdTD_y-ef7bPoyz3XJacxJJTXgmlIMkvCSc0MMKChbaUxTtEYTpQgtqapJCW1bSSYVVw1TNSO8oVBO0N1hd-3dzwZCFCsbNHSd7MFtgmCc05rxJoHVAdTeheDBiLW3K-l3gmCxNyj2esRej-CN-DMoWKrdDPsbtYL2WBqUpfx2yGXQsjNe9tqGI0bTk4TssecDBsnF1oIXQVvoNbTWJ9midfb_P34BsZqNPw</recordid><startdate>19890301</startdate><enddate>19890301</enddate><creator>Klein, Ami</creator><creator>Bruser, Barbara</creator><creator>Malkin, Aaron</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890301</creationdate><title>The effect of fatty acids on the vulnerability of lymphocytes to cortisol</title><author>Klein, Ami ; Bruser, Barbara ; Malkin, Aaron</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-14ace05660ea18388f1febe3daff92dfc1bb1636b513edd4a7ab8b97b571896e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adrenals. Interrenals</topic><topic>Adrenocortical hormones. Regulation</topic><topic>Arachidonic Acid</topic><topic>Arachidonic Acids - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Survival - drug effects</topic><topic>Dinoprostone - pharmacology</topic><topic>Drug Resistance</topic><topic>Eicosapentaenoic Acid - pharmacology</topic><topic>Fatty Acids - pharmacology</topic><topic>Fatty Acids, Unsaturated - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hydrocortisone - metabolism</topic><topic>Indomethacin - pharmacology</topic><topic>Linoleic Acid</topic><topic>Linoleic Acids - pharmacology</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - metabolism</topic><topic>Lymphocytes - pathology</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klein, Ami</creatorcontrib><creatorcontrib>Bruser, Barbara</creatorcontrib><creatorcontrib>Malkin, Aaron</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klein, Ami</au><au>Bruser, Barbara</au><au>Malkin, Aaron</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of fatty acids on the vulnerability of lymphocytes to cortisol</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>1989-03-01</date><risdate>1989</risdate><volume>38</volume><issue>3</issue><spage>278</spage><epage>281</epage><pages>278-281</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>We have shown previously that cortisol-sensitive lymphocytes (thymocytes) have a much lower capacity than cortisolresistant cells to catabolize cortisol and that linoleic acid inhibits the catabolism of cortisol by lymphocytes and modulates the sensitivity of lymphocytes to cortisol. In the present study, we attempted to see whether other fatty acids are inhibitory and if inhibition of cortisol catabolism by lymphocytes indicates a change in resistance of the cells to cortisol. Measuring the effect of fatty acids on cortisol catabolism by lymphocytes indicated that the polyunsaturated fatty acids, linoleate, arachidonate, and eicosapenteenoic, inhibit cortisol catabolism by lymphocytes. Using prostaglandin PGE
2 and indomethacin as a blocker of prostaglandin formation, we observed that the effect of the polyunsaturated fatty acids was not due to the formation of prostaglandins. Examining the effect of fatty acids on the vulnerability of lymphocytes to cortisol, we noted that saturated fatty acids had no significant effect, whereas the aforementioned polyunsaturated fatty acids make lymphocytes more sensitive to cortisol.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2537454</pmid><doi>10.1016/0026-0495(89)90088-7</doi><tpages>4</tpages></addata></record> |
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| ispartof | Metabolism, clinical and experimental, 1989-03, Vol.38 (3), p.278-281 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adrenals. Interrenals Adrenocortical hormones. Regulation Arachidonic Acid Arachidonic Acids - pharmacology Biological and medical sciences Cell Survival - drug effects Dinoprostone - pharmacology Drug Resistance Eicosapentaenoic Acid - pharmacology Fatty Acids - pharmacology Fatty Acids, Unsaturated - pharmacology Fundamental and applied biological sciences. Psychology Humans Hydrocortisone - metabolism Indomethacin - pharmacology Linoleic Acid Linoleic Acids - pharmacology Lymphocytes - drug effects Lymphocytes - metabolism Lymphocytes - pathology Vertebrates: endocrinology |
| title | The effect of fatty acids on the vulnerability of lymphocytes to cortisol |
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