Aging: effects on minimum alveolar concentration (MAC) for halothane in Fischer-344 rats
It is well-established that the anesthetic requirement (MAC) of volatile agents such as halothane is reduced in elderly patients. The current project was designed to determine whether a similar alteration in anesthetic requirement occurs in Fischer-344 (F-344) rats, an animal model often utilized in...
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| Veröffentlicht in: | Anesthesia and analgesia 1989-03, Vol.68 (3), p.359-362 |
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| container_title | Anesthesia and analgesia |
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| creator | LOSS, G. E. JR SEIFEN, E KENNEDY, R. H SEIFEN, A. B |
| description | It is well-established that the anesthetic requirement (MAC) of volatile agents such as halothane is reduced in elderly patients. The current project was designed to determine whether a similar alteration in anesthetic requirement occurs in Fischer-344 (F-344) rats, an animal model often utilized in physiology and pharmacology to examine aging-related changes. Animals were exposed to increasing or decreasing levels of halothane. After equilibration at each concentration, the response to tail-clamping was used for MAC testing. MAC was reduced approximately 17% in aged (25 months) versus young adult (5 months) animals. From these data, it is concluded that the F-344 rat may be an adequate model for examination of age-dependent alterations in the actions of volatile anesthetics. |
| doi_str_mv | 10.1213/00000539-198903000-00033 |
| format | Article |
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E. JR ; SEIFEN, E ; KENNEDY, R. H ; SEIFEN, A. B</creator><creatorcontrib>LOSS, G. E. JR ; SEIFEN, E ; KENNEDY, R. H ; SEIFEN, A. B</creatorcontrib><description>It is well-established that the anesthetic requirement (MAC) of volatile agents such as halothane is reduced in elderly patients. The current project was designed to determine whether a similar alteration in anesthetic requirement occurs in Fischer-344 (F-344) rats, an animal model often utilized in physiology and pharmacology to examine aging-related changes. Animals were exposed to increasing or decreasing levels of halothane. After equilibration at each concentration, the response to tail-clamping was used for MAC testing. MAC was reduced approximately 17% in aged (25 months) versus young adult (5 months) animals. From these data, it is concluded that the F-344 rat may be an adequate model for examination of age-dependent alterations in the actions of volatile anesthetics.</description><identifier>ISSN: 0003-2999</identifier><identifier>EISSN: 1526-7598</identifier><identifier>DOI: 10.1213/00000539-198903000-00033</identifier><identifier>PMID: 2493207</identifier><identifier>CODEN: AACRAT</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Aging - physiology ; Anesthetics. Neuromuscular blocking agents ; Animals ; Biological and medical sciences ; Body Temperature - drug effects ; Carbon Dioxide - blood ; Dose-Response Relationship, Drug ; Halothane - pharmacology ; Male ; Medical sciences ; Neuropharmacology ; Oxygen - blood ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred F344</subject><ispartof>Anesthesia and analgesia, 1989-03, Vol.68 (3), p.359-362</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7146996$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2493207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LOSS, G. E. JR</creatorcontrib><creatorcontrib>SEIFEN, E</creatorcontrib><creatorcontrib>KENNEDY, R. H</creatorcontrib><creatorcontrib>SEIFEN, A. B</creatorcontrib><title>Aging: effects on minimum alveolar concentration (MAC) for halothane in Fischer-344 rats</title><title>Anesthesia and analgesia</title><addtitle>Anesth Analg</addtitle><description>It is well-established that the anesthetic requirement (MAC) of volatile agents such as halothane is reduced in elderly patients. The current project was designed to determine whether a similar alteration in anesthetic requirement occurs in Fischer-344 (F-344) rats, an animal model often utilized in physiology and pharmacology to examine aging-related changes. Animals were exposed to increasing or decreasing levels of halothane. After equilibration at each concentration, the response to tail-clamping was used for MAC testing. MAC was reduced approximately 17% in aged (25 months) versus young adult (5 months) animals. From these data, it is concluded that the F-344 rat may be an adequate model for examination of age-dependent alterations in the actions of volatile anesthetics.</description><subject>Aging - physiology</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Temperature - drug effects</subject><subject>Carbon Dioxide - blood</subject><subject>Dose-Response Relationship, Drug</subject><subject>Halothane - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Oxygen - blood</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><issn>0003-2999</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF1LwzAUhoMoc05_gpALEb2o5qPNh3djOBUm3ih4V7L0ZKu06UxawX9vpnOBEE7e95y8eRDClNxQRvkt2a6C64xqpQlPRZY25wdoTAsmMllodYjG27uMaa2P0UmMH6mkRIkRGrFcc0bkGL1PV7Vf3WFwDmwfcedxW_u6HVpsmi_oGhOw7bwF3wfT10m-ep7OrrHrAl6bpuvXxgOuPZ7X0a4hZDzPcXLGU3TkTBPhbHdO0Nv8_nX2mC1eHp5m00Vmmcr7zBrt6NISseRAgEipSQVVboFLWkFBCFhHC8FVBS7FZ1Jxnr5AwLFcMMH5BF3-zd2E7nOA2JdtSgJNk3J1QyylUiKXhUxG9We0oYsxgCs3oW5N-C4pKbdQy3-o5R5q-Qs1tZ7v3hiWLVT7xh3FpF_sdBOtaVww3tZxb5M0F1oL_gPUrH0a</recordid><startdate>19890301</startdate><enddate>19890301</enddate><creator>LOSS, G. E. JR</creator><creator>SEIFEN, E</creator><creator>KENNEDY, R. H</creator><creator>SEIFEN, A. B</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890301</creationdate><title>Aging: effects on minimum alveolar concentration (MAC) for halothane in Fischer-344 rats</title><author>LOSS, G. E. JR ; SEIFEN, E ; KENNEDY, R. H ; SEIFEN, A. B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-ca9f1bc06b3e0e07790ded4ce371de500ecf15638def000278330860ef2462633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Aging - physiology</topic><topic>Anesthetics. Neuromuscular blocking agents</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Temperature - drug effects</topic><topic>Carbon Dioxide - blood</topic><topic>Dose-Response Relationship, Drug</topic><topic>Halothane - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Oxygen - blood</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LOSS, G. E. JR</creatorcontrib><creatorcontrib>SEIFEN, E</creatorcontrib><creatorcontrib>KENNEDY, R. H</creatorcontrib><creatorcontrib>SEIFEN, A. 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B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aging: effects on minimum alveolar concentration (MAC) for halothane in Fischer-344 rats</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>1989-03-01</date><risdate>1989</risdate><volume>68</volume><issue>3</issue><spage>359</spage><epage>362</epage><pages>359-362</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><coden>AACRAT</coden><abstract>It is well-established that the anesthetic requirement (MAC) of volatile agents such as halothane is reduced in elderly patients. The current project was designed to determine whether a similar alteration in anesthetic requirement occurs in Fischer-344 (F-344) rats, an animal model often utilized in physiology and pharmacology to examine aging-related changes. Animals were exposed to increasing or decreasing levels of halothane. After equilibration at each concentration, the response to tail-clamping was used for MAC testing. MAC was reduced approximately 17% in aged (25 months) versus young adult (5 months) animals. From these data, it is concluded that the F-344 rat may be an adequate model for examination of age-dependent alterations in the actions of volatile anesthetics.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>2493207</pmid><doi>10.1213/00000539-198903000-00033</doi><tpages>4</tpages></addata></record> |
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| ispartof | Anesthesia and analgesia, 1989-03, Vol.68 (3), p.359-362 |
| issn | 0003-2999 1526-7598 |
| language | eng |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Aging - physiology Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Body Temperature - drug effects Carbon Dioxide - blood Dose-Response Relationship, Drug Halothane - pharmacology Male Medical sciences Neuropharmacology Oxygen - blood Pharmacology. Drug treatments Rats Rats, Inbred F344 |
| title | Aging: effects on minimum alveolar concentration (MAC) for halothane in Fischer-344 rats |
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