Tissue characterization of symptomatic and asymptomatic disc herniations by quantitative magnetic resonance imaging
The purpose of this investigation was to determine differences in tissue composition of symptomatic and asymptomatic disc herniations as reflected in T1 and T2 relaxation times (quantitative magnetic resonance investigation of the lumber spine. The longitudinal and transverse magnetic rlaxation time...
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| Veröffentlicht in: | Journal of orthopaedic research 1997-01, Vol.15 (1), p.141-149 |
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| container_title | Journal of orthopaedic research |
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| creator | Boos, Norbert Dreier, Daniel Hilfiker, Esther Schade, Volker Kreis, Roland Hora, Josef Aebi, Max Boesch, Chris |
| description | The purpose of this investigation was to determine differences in tissue composition of symptomatic and asymptomatic disc herniations as reflected in T1 and T2 relaxation times (quantitative magnetic resonance investigation of the lumber spine. The longitudinal and transverse magnetic rlaxation times (T1 and T2, respectively) were calculated from a set of 20 images obtained with five single‐slice/multi‐echo sequences at different repetition time values on a commercial whole‐body system (1.5 T). Twenty‐two symptomatic and asymptomatic disc herniations could be matched according to age, gender, disc level, and the extent of herniation (protrusion or extrusion) and were compared with regard to T1 and T2 relaxation times. Symptomatic disc herniations exhibited significantly (pT1 < 0.04 and pT2 < 0.003) shorter T1(ΔT1:–182.1 milliseconds, −15%) and T2(ΔT2: −11.0 milliseconds, −21%) relaxation times than matched asymptomatic herniations. Symptomatic disc herniations also exhibited more advanced disc degeneration as graded by Pearce's criteria (p < 0.01). These results suggest that symptomatic and morphologically matched asymptomatic disc herniations differ with regard to disc matrix composition. |
| doi_str_mv | 10.1002/jor.1100150121 |
| format | Article |
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The longitudinal and transverse magnetic rlaxation times (T1 and T2, respectively) were calculated from a set of 20 images obtained with five single‐slice/multi‐echo sequences at different repetition time values on a commercial whole‐body system (1.5 T). Twenty‐two symptomatic and asymptomatic disc herniations could be matched according to age, gender, disc level, and the extent of herniation (protrusion or extrusion) and were compared with regard to T1 and T2 relaxation times. Symptomatic disc herniations exhibited significantly (pT1 < 0.04 and pT2 < 0.003) shorter T1(ΔT1:–182.1 milliseconds, −15%) and T2(ΔT2: −11.0 milliseconds, −21%) relaxation times than matched asymptomatic herniations. Symptomatic disc herniations also exhibited more advanced disc degeneration as graded by Pearce's criteria (p < 0.01). These results suggest that symptomatic and morphologically matched asymptomatic disc herniations differ with regard to disc matrix composition.</description><identifier>ISSN: 0736-0266</identifier><identifier>EISSN: 1554-527X</identifier><identifier>DOI: 10.1002/jor.1100150121</identifier><identifier>PMID: 9066539</identifier><identifier>CODEN: JOREDR</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Back Pain - diagnosis ; Back Pain - etiology ; Back Pain - pathology ; Female ; Humans ; Intervertebral Disc Displacement - complications ; Intervertebral Disc Displacement - diagnosis ; Intervertebral Disc Displacement - pathology ; Magnetic Resonance Imaging - standards ; Male ; Matched-Pair Analysis ; Middle Aged ; Quality Control ; Sex Distribution ; Thoracic Vertebrae</subject><ispartof>Journal of orthopaedic research, 1997-01, Vol.15 (1), p.141-149</ispartof><rights>Copyright © 1997 Orthopaedic Research Society</rights><rights>Copyright Journal of Bone and Joint Surgery, Inc. Jan 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4361-70ca9ec2d9dd65bf26b404d3fed2eabe981b78a05d8a1aae56d0eeb8d7a0bc493</citedby><cites>FETCH-LOGICAL-c4361-70ca9ec2d9dd65bf26b404d3fed2eabe981b78a05d8a1aae56d0eeb8d7a0bc493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjor.1100150121$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjor.1100150121$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9066539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boos, Norbert</creatorcontrib><creatorcontrib>Dreier, Daniel</creatorcontrib><creatorcontrib>Hilfiker, Esther</creatorcontrib><creatorcontrib>Schade, Volker</creatorcontrib><creatorcontrib>Kreis, Roland</creatorcontrib><creatorcontrib>Hora, Josef</creatorcontrib><creatorcontrib>Aebi, Max</creatorcontrib><creatorcontrib>Boesch, Chris</creatorcontrib><title>Tissue characterization of symptomatic and asymptomatic disc herniations by quantitative magnetic resonance imaging</title><title>Journal of orthopaedic research</title><addtitle>J. Orthop. Res</addtitle><description>The purpose of this investigation was to determine differences in tissue composition of symptomatic and asymptomatic disc herniations as reflected in T1 and T2 relaxation times (quantitative magnetic resonance investigation of the lumber spine. The longitudinal and transverse magnetic rlaxation times (T1 and T2, respectively) were calculated from a set of 20 images obtained with five single‐slice/multi‐echo sequences at different repetition time values on a commercial whole‐body system (1.5 T). Twenty‐two symptomatic and asymptomatic disc herniations could be matched according to age, gender, disc level, and the extent of herniation (protrusion or extrusion) and were compared with regard to T1 and T2 relaxation times. Symptomatic disc herniations exhibited significantly (pT1 < 0.04 and pT2 < 0.003) shorter T1(ΔT1:–182.1 milliseconds, −15%) and T2(ΔT2: −11.0 milliseconds, −21%) relaxation times than matched asymptomatic herniations. Symptomatic disc herniations also exhibited more advanced disc degeneration as graded by Pearce's criteria (p < 0.01). These results suggest that symptomatic and morphologically matched asymptomatic disc herniations differ with regard to disc matrix composition.</description><subject>Adult</subject><subject>Back Pain - diagnosis</subject><subject>Back Pain - etiology</subject><subject>Back Pain - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Intervertebral Disc Displacement - complications</subject><subject>Intervertebral Disc Displacement - diagnosis</subject><subject>Intervertebral Disc Displacement - pathology</subject><subject>Magnetic Resonance Imaging - standards</subject><subject>Male</subject><subject>Matched-Pair Analysis</subject><subject>Middle Aged</subject><subject>Quality Control</subject><subject>Sex Distribution</subject><subject>Thoracic Vertebrae</subject><issn>0736-0266</issn><issn>1554-527X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUtvEzEUhS0EKmlhyw7JYsFugh9je7xEFTSUiEooPHaWx77TOmQ8qT1DCb8el0TlsenK9rnfOfLVQegZJXNKCHu1HtKclhsVhDL6AM2oEHUlmPr6EM2I4rIiTMrH6DjnNSFEUdYcoSNNpBRcz1BehZwnwO7KJutGSOGnHcMQ8dDhvOu349CXt8M2emz_FnzIDl9BiuE3n3G7w9eTjWMYi_AdcG8vI9ySCfIQbXSAQ9FCvHyCHnV2k-Hp4TxBn96-WZ0uquXF2bvT18vK1VzSShFnNTjmtfdStB2TbU1qzzvwDGwLuqGtaiwRvrHUWhDSE4C28cqS1tWan6CX-9xtGq4nyKPpy6dhs7ERhikb1TSyrhW7F6RCK10zXsAX_4HrYUqxLGEYF5QTqlSB5nvIpSHnBJ3ZprJ52hlKzG1nxZTMn86K4fkhdWp78Hf4oaQy1_v5TdjA7p40c37x8Z_sau8NeYQfd16bvhmpuBLmy4czs3j_uVkuVtqc81_TtbWe</recordid><startdate>199701</startdate><enddate>199701</enddate><creator>Boos, Norbert</creator><creator>Dreier, Daniel</creator><creator>Hilfiker, Esther</creator><creator>Schade, Volker</creator><creator>Kreis, Roland</creator><creator>Hora, Josef</creator><creator>Aebi, Max</creator><creator>Boesch, Chris</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>199701</creationdate><title>Tissue characterization of symptomatic and asymptomatic disc herniations by quantitative magnetic resonance imaging</title><author>Boos, Norbert ; 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Orthop. Res</addtitle><date>1997-01</date><risdate>1997</risdate><volume>15</volume><issue>1</issue><spage>141</spage><epage>149</epage><pages>141-149</pages><issn>0736-0266</issn><eissn>1554-527X</eissn><coden>JOREDR</coden><abstract>The purpose of this investigation was to determine differences in tissue composition of symptomatic and asymptomatic disc herniations as reflected in T1 and T2 relaxation times (quantitative magnetic resonance investigation of the lumber spine. The longitudinal and transverse magnetic rlaxation times (T1 and T2, respectively) were calculated from a set of 20 images obtained with five single‐slice/multi‐echo sequences at different repetition time values on a commercial whole‐body system (1.5 T). Twenty‐two symptomatic and asymptomatic disc herniations could be matched according to age, gender, disc level, and the extent of herniation (protrusion or extrusion) and were compared with regard to T1 and T2 relaxation times. Symptomatic disc herniations exhibited significantly (pT1 < 0.04 and pT2 < 0.003) shorter T1(ΔT1:–182.1 milliseconds, −15%) and T2(ΔT2: −11.0 milliseconds, −21%) relaxation times than matched asymptomatic herniations. Symptomatic disc herniations also exhibited more advanced disc degeneration as graded by Pearce's criteria (p < 0.01). These results suggest that symptomatic and morphologically matched asymptomatic disc herniations differ with regard to disc matrix composition.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>9066539</pmid><doi>10.1002/jor.1100150121</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of orthopaedic research, 1997-01, Vol.15 (1), p.141-149 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Back Pain - diagnosis Back Pain - etiology Back Pain - pathology Female Humans Intervertebral Disc Displacement - complications Intervertebral Disc Displacement - diagnosis Intervertebral Disc Displacement - pathology Magnetic Resonance Imaging - standards Male Matched-Pair Analysis Middle Aged Quality Control Sex Distribution Thoracic Vertebrae |
| title | Tissue characterization of symptomatic and asymptomatic disc herniations by quantitative magnetic resonance imaging |
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