Overexpression of c-Myc and cell immortalization alters c-Myc phosphorylation

Using an extensive series of deletion and site-specific mutation constructs, we have identified five new phosphorylation sites in c-Myc in the N-terminal transactivation domain and near the C-terminal DNA binding/heterodimerization domain. We have also found that Thr-58 phosphorylation is regulated...

Ausführliche Beschreibung