Physiological role of endothelin in cardiovascular and renal hemodynamics: studies in animals
Even though the pharmacology of the endothelin receptor subtypes ETB and ETB is well characterized, their physiological role in the control of basal vascular tone is poorly uindertood. It has been proposed that a tonic vasoconstriction mediated by endothelin counterbalances a vasodilator tone mediat...
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| Veröffentlicht in: | Current opinion in nephrology and hypertension 1997-01, Vol.6 (1), p.64-68 |
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| container_title | Current opinion in nephrology and hypertension |
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| creator | Gellai, Miklos |
| description | Even though the pharmacology of the endothelin receptor subtypes ETB and ETB is well characterized, their physiological role in the control of basal vascular tone is poorly uindertood. It has been proposed that a tonic vasoconstriction mediated by endothelin counterbalances a vasodilator tone mediated by nitric oxide, the major endothelium-derived relaxing factor. Recent evidence suggest that the endogenous endothelin-1, released from the endothelial cells, mediates both vasodilation and vasoconstriction and indicates the existence of a negative feedback system involving endothelin-1, the endothelial ETB receptor and nitric oxide |
| doi_str_mv | 10.1097/00041552-199701000-00012 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Current opinion in nephrology and hypertension, 1997-01, Vol.6 (1), p.64-68 |
| issn | 1062-4821 1473-6543 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Cardiovascular Physiological Phenomena Endothelins - physiology Receptors, Endothelin - physiology Renal Circulation - physiology |
| title | Physiological role of endothelin in cardiovascular and renal hemodynamics: studies in animals |
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