A new measure of health status for clinical trials in inflammatory bowel disease
We have developed a measure of subjective health status (quality of life) for patients with inflammatory bowel disease (IBD). Ninety-seven patients with IBD described problems they had experienced as a result of the disease; the 32 most frequent and important items were included in the Inflammatory...
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Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1989-03, Vol.96 (3), p.804-810 |
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creator | Guyatt, Gordon Mitchell, Alba Irvine, E.Jan Singer, Joel Williams, Nancy Goodacre, Robert Tompkins, Cathy |
description | We have developed a measure of subjective health status (quality of life) for patients with inflammatory bowel disease (IBD). Ninety-seven patients with IBD described problems they had experienced as a result of the disease; the 32 most frequent and important items were included in the Inflammatory Bowel Disease Questionnaire (IBDQ). Sixty-one IBD patients were evaluated twice. One month separated the evaluations, at which disease activity indices, the IBDQ, and a number of other questionnaires were administered. Reproducibility studies in 19 stable patients showed improvement in scores, but also a small within-person standard deviation. Responsiveness studies revealed large changes in scores in patients who had improved or deteriorated and suggested that the IBDQ was more responsive than a general health status measure. Responsiveness appeared greater in patients with ulcerative colitis than in those with Crohn's disease. Predicted and observed correlations between changes in IBDQ score and changes in other measures were similar. We conclude that although further testing is required, particularly in examining the relation between changes in the IBDQ and changes in the activity of Crohn's disease, the IBDQ shows promise as a measure of health status for clinical trials in IBD. |
doi_str_mv | 10.1016/0016-5085(89)90905-0 |
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Ninety-seven patients with IBD described problems they had experienced as a result of the disease; the 32 most frequent and important items were included in the Inflammatory Bowel Disease Questionnaire (IBDQ). Sixty-one IBD patients were evaluated twice. One month separated the evaluations, at which disease activity indices, the IBDQ, and a number of other questionnaires were administered. Reproducibility studies in 19 stable patients showed improvement in scores, but also a small within-person standard deviation. Responsiveness studies revealed large changes in scores in patients who had improved or deteriorated and suggested that the IBDQ was more responsive than a general health status measure. Responsiveness appeared greater in patients with ulcerative colitis than in those with Crohn's disease. Predicted and observed correlations between changes in IBDQ score and changes in other measures were similar. We conclude that although further testing is required, particularly in examining the relation between changes in the IBDQ and changes in the activity of Crohn's disease, the IBDQ shows promise as a measure of health status for clinical trials in IBD.</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1016/0016-5085(89)90905-0</identifier><identifier>PMID: 2644154</identifier><identifier>CODEN: GASTAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Attitude to Health ; Biological and medical sciences ; Clinical Trials as Topic ; Gastroenterology. Liver. Pancreas. Abdomen ; Health Status Indicators ; Health Surveys ; Humans ; Inflammatory Bowel Diseases - diagnosis ; Inflammatory Bowel Diseases - psychology ; Medical sciences ; Other diseases. Semiology ; Quality of Life ; Reproducibility of Results ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surveys and Questionnaires</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 1989-03, Vol.96 (3), p.804-810</ispartof><rights>1989</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-4ce9d24c6fee42b4d7f379f61ae7c205a8e4c4d700d064c10b624e295515a503</citedby><cites>FETCH-LOGICAL-c525t-4ce9d24c6fee42b4d7f379f61ae7c205a8e4c4d700d064c10b624e295515a503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0016-5085(89)90905-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7238306$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2644154$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guyatt, Gordon</creatorcontrib><creatorcontrib>Mitchell, Alba</creatorcontrib><creatorcontrib>Irvine, E.Jan</creatorcontrib><creatorcontrib>Singer, Joel</creatorcontrib><creatorcontrib>Williams, Nancy</creatorcontrib><creatorcontrib>Goodacre, Robert</creatorcontrib><creatorcontrib>Tompkins, Cathy</creatorcontrib><title>A new measure of health status for clinical trials in inflammatory bowel disease</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>We have developed a measure of subjective health status (quality of life) for patients with inflammatory bowel disease (IBD). Ninety-seven patients with IBD described problems they had experienced as a result of the disease; the 32 most frequent and important items were included in the Inflammatory Bowel Disease Questionnaire (IBDQ). Sixty-one IBD patients were evaluated twice. One month separated the evaluations, at which disease activity indices, the IBDQ, and a number of other questionnaires were administered. Reproducibility studies in 19 stable patients showed improvement in scores, but also a small within-person standard deviation. Responsiveness studies revealed large changes in scores in patients who had improved or deteriorated and suggested that the IBDQ was more responsive than a general health status measure. Responsiveness appeared greater in patients with ulcerative colitis than in those with Crohn's disease. Predicted and observed correlations between changes in IBDQ score and changes in other measures were similar. We conclude that although further testing is required, particularly in examining the relation between changes in the IBDQ and changes in the activity of Crohn's disease, the IBDQ shows promise as a measure of health status for clinical trials in IBD.</description><subject>Attitude to Health</subject><subject>Biological and medical sciences</subject><subject>Clinical Trials as Topic</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Health Status Indicators</subject><subject>Health Surveys</subject><subject>Humans</subject><subject>Inflammatory Bowel Diseases - diagnosis</subject><subject>Inflammatory Bowel Diseases - psychology</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Quality of Life</subject><subject>Reproducibility of Results</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Surveys and Questionnaires</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LBCEUhiWK2j7-QYEXEXUxdXR0Rm-CWPqCoC66F9c5kjEfpTNF_z63XfYyEAXf57wcHkKOGVwyYNUV5KuQoOS50hcaNMgCtsiMSa6KnPFtMtsge2Q_pXcA0KViu2SXV0IwKWbk5Yb2-E07tGmKSAdP39C24xtNox2nRP0QqWtDH5xt6RiDbRMNfT6-tV1nxyH-0MXwjS1tQsoleEh2fIbwaP0ekNe729f5Q_H0fP84v3kqnORyLIRD3XDhKo8o-EI0tS9r7StmsXYcpFUoXP4FaKASjsGi4gK5lpJJK6E8IGer2o84fE6YRtOF5LBtbY_DlEytVAVayAyKFejikFJEbz5i6Gz8MQzM0qNZSjJLSUZp8-fRLPtP1v3TosNmM7QWl_PTdW5TVuOj7V1IG6zmpSqhytj1CsOs4itgNMkF7B02IaIbTTOE__f4BScPjf0</recordid><startdate>19890301</startdate><enddate>19890301</enddate><creator>Guyatt, Gordon</creator><creator>Mitchell, Alba</creator><creator>Irvine, E.Jan</creator><creator>Singer, Joel</creator><creator>Williams, Nancy</creator><creator>Goodacre, Robert</creator><creator>Tompkins, Cathy</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890301</creationdate><title>A new measure of health status for clinical trials in inflammatory bowel disease</title><author>Guyatt, Gordon ; Mitchell, Alba ; Irvine, E.Jan ; Singer, Joel ; Williams, Nancy ; Goodacre, Robert ; Tompkins, Cathy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-4ce9d24c6fee42b4d7f379f61ae7c205a8e4c4d700d064c10b624e295515a503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Attitude to Health</topic><topic>Biological and medical sciences</topic><topic>Clinical Trials as Topic</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Health Status Indicators</topic><topic>Health Surveys</topic><topic>Humans</topic><topic>Inflammatory Bowel Diseases - diagnosis</topic><topic>Inflammatory Bowel Diseases - psychology</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Quality of Life</topic><topic>Reproducibility of Results</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guyatt, Gordon</creatorcontrib><creatorcontrib>Mitchell, Alba</creatorcontrib><creatorcontrib>Irvine, E.Jan</creatorcontrib><creatorcontrib>Singer, Joel</creatorcontrib><creatorcontrib>Williams, Nancy</creatorcontrib><creatorcontrib>Goodacre, Robert</creatorcontrib><creatorcontrib>Tompkins, Cathy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guyatt, Gordon</au><au>Mitchell, Alba</au><au>Irvine, E.Jan</au><au>Singer, Joel</au><au>Williams, Nancy</au><au>Goodacre, Robert</au><au>Tompkins, Cathy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new measure of health status for clinical trials in inflammatory bowel disease</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>1989-03-01</date><risdate>1989</risdate><volume>96</volume><issue>3</issue><spage>804</spage><epage>810</epage><pages>804-810</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><coden>GASTAB</coden><abstract>We have developed a measure of subjective health status (quality of life) for patients with inflammatory bowel disease (IBD). Ninety-seven patients with IBD described problems they had experienced as a result of the disease; the 32 most frequent and important items were included in the Inflammatory Bowel Disease Questionnaire (IBDQ). Sixty-one IBD patients were evaluated twice. One month separated the evaluations, at which disease activity indices, the IBDQ, and a number of other questionnaires were administered. Reproducibility studies in 19 stable patients showed improvement in scores, but also a small within-person standard deviation. Responsiveness studies revealed large changes in scores in patients who had improved or deteriorated and suggested that the IBDQ was more responsive than a general health status measure. Responsiveness appeared greater in patients with ulcerative colitis than in those with Crohn's disease. Predicted and observed correlations between changes in IBDQ score and changes in other measures were similar. We conclude that although further testing is required, particularly in examining the relation between changes in the IBDQ and changes in the activity of Crohn's disease, the IBDQ shows promise as a measure of health status for clinical trials in IBD.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2644154</pmid><doi>10.1016/0016-5085(89)90905-0</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Attitude to Health Biological and medical sciences Clinical Trials as Topic Gastroenterology. Liver. Pancreas. Abdomen Health Status Indicators Health Surveys Humans Inflammatory Bowel Diseases - diagnosis Inflammatory Bowel Diseases - psychology Medical sciences Other diseases. Semiology Quality of Life Reproducibility of Results Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surveys and Questionnaires |
title | A new measure of health status for clinical trials in inflammatory bowel disease |
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