A new measure of health status for clinical trials in inflammatory bowel disease

We have developed a measure of subjective health status (quality of life) for patients with inflammatory bowel disease (IBD). Ninety-seven patients with IBD described problems they had experienced as a result of the disease; the 32 most frequent and important items were included in the Inflammatory...

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Veröffentlicht in:Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1989-03, Vol.96 (3), p.804-810
Hauptverfasser: Guyatt, Gordon, Mitchell, Alba, Irvine, E.Jan, Singer, Joel, Williams, Nancy, Goodacre, Robert, Tompkins, Cathy
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container_end_page 810
container_issue 3
container_start_page 804
container_title Gastroenterology (New York, N.Y. 1943)
container_volume 96
creator Guyatt, Gordon
Mitchell, Alba
Irvine, E.Jan
Singer, Joel
Williams, Nancy
Goodacre, Robert
Tompkins, Cathy
description We have developed a measure of subjective health status (quality of life) for patients with inflammatory bowel disease (IBD). Ninety-seven patients with IBD described problems they had experienced as a result of the disease; the 32 most frequent and important items were included in the Inflammatory Bowel Disease Questionnaire (IBDQ). Sixty-one IBD patients were evaluated twice. One month separated the evaluations, at which disease activity indices, the IBDQ, and a number of other questionnaires were administered. Reproducibility studies in 19 stable patients showed improvement in scores, but also a small within-person standard deviation. Responsiveness studies revealed large changes in scores in patients who had improved or deteriorated and suggested that the IBDQ was more responsive than a general health status measure. Responsiveness appeared greater in patients with ulcerative colitis than in those with Crohn's disease. Predicted and observed correlations between changes in IBDQ score and changes in other measures were similar. We conclude that although further testing is required, particularly in examining the relation between changes in the IBDQ and changes in the activity of Crohn's disease, the IBDQ shows promise as a measure of health status for clinical trials in IBD.
doi_str_mv 10.1016/0016-5085(89)90905-0
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We conclude that although further testing is required, particularly in examining the relation between changes in the IBDQ and changes in the activity of Crohn's disease, the IBDQ shows promise as a measure of health status for clinical trials in IBD.</description><subject>Attitude to Health</subject><subject>Biological and medical sciences</subject><subject>Clinical Trials as Topic</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Health Status Indicators</subject><subject>Health Surveys</subject><subject>Humans</subject><subject>Inflammatory Bowel Diseases - diagnosis</subject><subject>Inflammatory Bowel Diseases - psychology</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Quality of Life</subject><subject>Reproducibility of Results</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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subjects Attitude to Health
Biological and medical sciences
Clinical Trials as Topic
Gastroenterology. Liver. Pancreas. Abdomen
Health Status Indicators
Health Surveys
Humans
Inflammatory Bowel Diseases - diagnosis
Inflammatory Bowel Diseases - psychology
Medical sciences
Other diseases. Semiology
Quality of Life
Reproducibility of Results
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Surveys and Questionnaires
title A new measure of health status for clinical trials in inflammatory bowel disease
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