Perturbation of Epidermal Growth Factor Clearance after Radioiodination and Its Implications

The clearance of human epidermal growth factor (hEGF1–53) has been thought to be mediated mainly by a high-capacity receptor system, yet relatively low in vivo clearance rates (120 min) have been observed in rats receiving the peptide that was iodinated by the oxidative chloramine-T (CT) method. We...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1997-03, Vol.86 (3), p.290-296
Hauptverfasser:	Kuo, Be-Sheng, Nordblom, Gerald D., Wright, D.Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Epidermal Growth Factor - blood Epidermal Growth Factor - metabolism Epidermal Growth Factor - pharmacokinetics General pharmacology Iodine Radioisotopes Male Medical sciences Molecular Sequence Data Peptide Fragments - blood Peptide Fragments - metabolism Peptide Fragments - pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Precipitin Tests Rats Rats, Wistar Receptor, Epidermal Growth Factor - metabolism Trichloroacetic Acid
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