Numerical model for calculation of apparent diffusion coefficients (ADC) in permeable cylinders-comparison with measured ADC in spinal cord white matter
We have implemented a numerical method for calculation of the apparent diffusion coefficient (ADC) in spinal cord injury, which takes into account the distribution of axon diameters and permeability found in spinal cord white matter, as well as relative axonal volume. We propose a procedure for dete...
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| Veröffentlicht in: | Magnetic resonance in medicine 1997-03, Vol.37 (3), p.387-394 |
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| container_title | Magnetic resonance in medicine |
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| creator | Ford, J. Chetley Hackney, David B. |
| description | We have implemented a numerical method for calculation of the apparent diffusion coefficient (ADC) in spinal cord injury, which takes into account the distribution of axon diameters and permeability found in spinal cord white matter, as well as relative axonal volume. We propose a procedure for determining the status of axonal integrity from measured ADC values. These methods have been applied to a well characterized rat spinal cord injury model, affording a prediction of the increase in axonal permeability which is presumed to be closely related to functional deficit. ADC values are compared to those calculated from analytical formulas in the literature, and possible factors underlying the ADC behavior are explored. Calculated results indicate both axonal swelling and cell membrane permeability to be important factors contributing to ADC in traumatic spinal cord injury. |
| doi_str_mv | 10.1002/mrm.1910370315 |
| format | Article |
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Calculated results indicate both axonal swelling and cell membrane permeability to be important factors contributing to ADC in traumatic spinal cord injury.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.1910370315</identifier><identifier>PMID: 9055229</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>Baltimore: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Axons - chemistry ; Axons - metabolism ; Biological and medical sciences ; Diffusion ; diffusion, MR ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Medical sciences ; Models, Theoretical ; Permeability ; Rats ; spinal cord ; Spinal Cord Injuries - metabolism ; Traumas. 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Chetley</creatorcontrib><creatorcontrib>Hackney, David B.</creatorcontrib><title>Numerical model for calculation of apparent diffusion coefficients (ADC) in permeable cylinders-comparison with measured ADC in spinal cord white matter</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>We have implemented a numerical method for calculation of the apparent diffusion coefficient (ADC) in spinal cord injury, which takes into account the distribution of axon diameters and permeability found in spinal cord white matter, as well as relative axonal volume. We propose a procedure for determining the status of axonal integrity from measured ADC values. These methods have been applied to a well characterized rat spinal cord injury model, affording a prediction of the increase in axonal permeability which is presumed to be closely related to functional deficit. ADC values are compared to those calculated from analytical formulas in the literature, and possible factors underlying the ADC behavior are explored. Calculated results indicate both axonal swelling and cell membrane permeability to be important factors contributing to ADC in traumatic spinal cord injury.</description><subject>Animals</subject><subject>Axons - chemistry</subject><subject>Axons - metabolism</subject><subject>Biological and medical sciences</subject><subject>Diffusion</subject><subject>diffusion, MR</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Medical sciences</subject><subject>Models, Theoretical</subject><subject>Permeability</subject><subject>Rats</subject><subject>spinal cord</subject><subject>Spinal Cord Injuries - metabolism</subject><subject>Traumas. Diseases due to physical agents</subject><subject>white matter</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQQC1EVbaFKzckHxAqhyx2Eif2sVqgrdQtEl89Wo49Vg1xHOxEy_4Tfi5e7WorTpwsz7znGc0YoZeULCkh5Tsf_ZIKSqqWVJQ9QQvKyrIomaifogVpa1JUVNTP0FlKPwghQrT1KToVhGVMLNCfu9lDdFr12AcDPbYh4nzTc68mFwYcLFbjqCIMEzbO2jntojqAtU67HE344vL96i12Ax4helBdD1hvezcYiKnQwWfbpSxt3PSAM5DmCAZnaeek0Q25uA7R4M2DmwB7NU0Qn6MTq_oELw7nOfr28cPX1XVx--nqZnV5W-iatKxoaFMbwVrKBRcdo602NWENF6WqOmq6TBlmKCkba2tia94ZXgLj3FBqu6apztGb_btjDL9mSJP0LmnoezVAmJNsOc-z5DSDyz2oY0gpgpVjdF7FraRE7lYh8yrk4yqy8Orw8tx5MEf8MPucf33Iq5QnbqMatEtHrMxNCl5mTOyxjeth-5-icv15_U8Lxd51aYLfR1fFn7Jpq5bJ-7sruf6SP8WafJf31V8tVLLH</recordid><startdate>199703</startdate><enddate>199703</enddate><creator>Ford, J. Chetley</creator><creator>Hackney, David B.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199703</creationdate><title>Numerical model for calculation of apparent diffusion coefficients (ADC) in permeable cylinders-comparison with measured ADC in spinal cord white matter</title><author>Ford, J. Chetley ; Hackney, David B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4075-6164d95718989b517cd4056892a3b1dbc40d5d1026ff40f48bd82e588d11fb663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Axons - chemistry</topic><topic>Axons - metabolism</topic><topic>Biological and medical sciences</topic><topic>Diffusion</topic><topic>diffusion, MR</topic><topic>Injuries of the nervous system and the skull. Diseases due to physical agents</topic><topic>Medical sciences</topic><topic>Models, Theoretical</topic><topic>Permeability</topic><topic>Rats</topic><topic>spinal cord</topic><topic>Spinal Cord Injuries - metabolism</topic><topic>Traumas. Diseases due to physical agents</topic><topic>white matter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ford, J. Chetley</creatorcontrib><creatorcontrib>Hackney, David B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ford, J. Chetley</au><au>Hackney, David B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Numerical model for calculation of apparent diffusion coefficients (ADC) in permeable cylinders-comparison with measured ADC in spinal cord white matter</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>1997-03</date><risdate>1997</risdate><volume>37</volume><issue>3</issue><spage>387</spage><epage>394</epage><pages>387-394</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>We have implemented a numerical method for calculation of the apparent diffusion coefficient (ADC) in spinal cord injury, which takes into account the distribution of axon diameters and permeability found in spinal cord white matter, as well as relative axonal volume. We propose a procedure for determining the status of axonal integrity from measured ADC values. These methods have been applied to a well characterized rat spinal cord injury model, affording a prediction of the increase in axonal permeability which is presumed to be closely related to functional deficit. ADC values are compared to those calculated from analytical formulas in the literature, and possible factors underlying the ADC behavior are explored. Calculated results indicate both axonal swelling and cell membrane permeability to be important factors contributing to ADC in traumatic spinal cord injury.</abstract><cop>Baltimore</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>9055229</pmid><doi>10.1002/mrm.1910370315</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0740-3194 |
| ispartof | Magnetic resonance in medicine, 1997-03, Vol.37 (3), p.387-394 |
| issn | 0740-3194 1522-2594 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animals Axons - chemistry Axons - metabolism Biological and medical sciences Diffusion diffusion, MR Injuries of the nervous system and the skull. Diseases due to physical agents Medical sciences Models, Theoretical Permeability Rats spinal cord Spinal Cord Injuries - metabolism Traumas. Diseases due to physical agents white matter |
| title | Numerical model for calculation of apparent diffusion coefficients (ADC) in permeable cylinders-comparison with measured ADC in spinal cord white matter |
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