Assessment of male infertility: Correlation between results of semen analysis and phosphorus-31 magnetic resonance spectroscopy
To evaluate the usefulness of phosphorus-31 magnetic resonance spectroscopy ( 31P-MRS) in assessing male infertility, we compared it with conventional semen analysis. Specimens were obtained from otherwise healthy patient groups as follows: group A, 7 fertile control subjects; group B, 12 azoospermi...
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| Veröffentlicht in: | Urology (Ridgewood, N.J.) N.J.), 1989-02, Vol.33 (2), p.116-119 |
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| container_title | Urology (Ridgewood, N.J.) |
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| creator | Bretan, Peter N. Vigneron, Daniel B. Hricak, Hedvig Tom, Raymond A. Moseley, Michael Tanagho, Emil A. James, Thomas L. |
| description | To evaluate the usefulness of phosphorus-31 magnetic resonance spectroscopy (
31P-MRS) in assessing male infertility, we compared it with conventional semen analysis. Specimens were obtained from otherwise healthy patient groups as follows: group A, 7 fertile control subjects; group B, 12 azoospermic men after vasectomy; and group C, 11 patients presenting for infertility evaluation. Correlations between established semen analysis parameters and the
31P-MRS-derived ratio of glycerylphosphorylcholine to total phosphate (GPCITP) were investigated. Group A controls had a mean GPCITC ratio of 0.10 ± 0.05, which was the same as that of group C. With the exception of significantly lowered motility and normal morphology in group C (p < 0.001 and 0.05, respectively) semen analysis parameters in these two groups were similar. In contrast, the GPC/TP ratio in group B (0.05 3NA 0.04) was significantly different from the control (p < 0.05), which appropriately reflected complete vasal occlusion. The results suggest that a significant portion of seminal GPC is derived from epididymal secretion and that
31P-MRS is useful for monitoring the GPC/TP levels when assessing epididymal function and male infertility. |
| doi_str_mv | 10.1016/0090-4295(89)90007-1 |
| format | Article |
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31P-MRS) in assessing male infertility, we compared it with conventional semen analysis. Specimens were obtained from otherwise healthy patient groups as follows: group A, 7 fertile control subjects; group B, 12 azoospermic men after vasectomy; and group C, 11 patients presenting for infertility evaluation. Correlations between established semen analysis parameters and the
31P-MRS-derived ratio of glycerylphosphorylcholine to total phosphate (GPCITP) were investigated. Group A controls had a mean GPCITC ratio of 0.10 ± 0.05, which was the same as that of group C. With the exception of significantly lowered motility and normal morphology in group C (p < 0.001 and 0.05, respectively) semen analysis parameters in these two groups were similar. In contrast, the GPC/TP ratio in group B (0.05 3NA 0.04) was significantly different from the control (p < 0.05), which appropriately reflected complete vasal occlusion. The results suggest that a significant portion of seminal GPC is derived from epididymal secretion and that
31P-MRS is useful for monitoring the GPC/TP levels when assessing epididymal function and male infertility.</description><identifier>ISSN: 0090-4295</identifier><identifier>EISSN: 1527-9995</identifier><identifier>DOI: 10.1016/0090-4295(89)90007-1</identifier><identifier>PMID: 2916284</identifier><identifier>CODEN: URGYAZ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Birth control ; Glycerylphosphorylcholine - analysis ; Gynecology. Andrology. Obstetrics ; Humans ; Infertility, Male - diagnosis ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Semen - analysis ; Sterility. Assisted procreation</subject><ispartof>Urology (Ridgewood, N.J.), 1989-02, Vol.33 (2), p.116-119</ispartof><rights>1989</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c301t-d00480a2b5f0c0cc15c1ed4b3d6ed5a04749f1f4ed19850b7e31106406a148943</citedby><cites>FETCH-LOGICAL-c301t-d00480a2b5f0c0cc15c1ed4b3d6ed5a04749f1f4ed19850b7e31106406a148943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0090-4295(89)90007-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7273051$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2916284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bretan, Peter N.</creatorcontrib><creatorcontrib>Vigneron, Daniel B.</creatorcontrib><creatorcontrib>Hricak, Hedvig</creatorcontrib><creatorcontrib>Tom, Raymond A.</creatorcontrib><creatorcontrib>Moseley, Michael</creatorcontrib><creatorcontrib>Tanagho, Emil A.</creatorcontrib><creatorcontrib>James, Thomas L.</creatorcontrib><title>Assessment of male infertility: Correlation between results of semen analysis and phosphorus-31 magnetic resonance spectroscopy</title><title>Urology (Ridgewood, N.J.)</title><addtitle>Urology</addtitle><description>To evaluate the usefulness of phosphorus-31 magnetic resonance spectroscopy (
31P-MRS) in assessing male infertility, we compared it with conventional semen analysis. Specimens were obtained from otherwise healthy patient groups as follows: group A, 7 fertile control subjects; group B, 12 azoospermic men after vasectomy; and group C, 11 patients presenting for infertility evaluation. Correlations between established semen analysis parameters and the
31P-MRS-derived ratio of glycerylphosphorylcholine to total phosphate (GPCITP) were investigated. Group A controls had a mean GPCITC ratio of 0.10 ± 0.05, which was the same as that of group C. With the exception of significantly lowered motility and normal morphology in group C (p < 0.001 and 0.05, respectively) semen analysis parameters in these two groups were similar. In contrast, the GPC/TP ratio in group B (0.05 3NA 0.04) was significantly different from the control (p < 0.05), which appropriately reflected complete vasal occlusion. The results suggest that a significant portion of seminal GPC is derived from epididymal secretion and that
31P-MRS is useful for monitoring the GPC/TP levels when assessing epididymal function and male infertility.</description><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Glycerylphosphorylcholine - analysis</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infertility, Male - diagnosis</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Semen - analysis</subject><subject>Sterility. Assisted procreation</subject><issn>0090-4295</issn><issn>1527-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMGK1TAUhoM4jNfRN1DoQkQX1ZM2aZtZCMNFnYEBN7oOaXqqkTapOanDXfnqpt7LXboIJ3C-_-fwMfaCwzsOvHkPoKAUlZJvOvVWAUBb8kdsx2XVlkop-ZjtzsgT9pToZ2aapmkv2WWleFN1Ysf-3BAh0Yw-FWEsZjNh4fyIMbnJpcN1sQ8x4mSSC77oMT0g-iIirVOiLUCYo4XxZjqQo_wZiuVHoPziSmXNc-N3j8nZLRS88RYLWtCmGMiG5fCMXYxmInx-mlfs26ePX_e35f2Xz3f7m_vS1sBTOQCIDkzVyxEsWMul5TiIvh4aHKQB0Qo18lHgwFUnoW-x5hwaAY3holOivmKvj71LDL9WpKRnRxanyXgMK-m262QjZZ1BcQRtvpAijnqJbjbxoDnozbvepOpNqu6U_udd8xx7eepf-xmHc-gkOu9fnfaGrJnGmE04OmNt1dYgt5oPRwyzi98OoybrMEsbXMzS9BDc_-_4CyujoME</recordid><startdate>198902</startdate><enddate>198902</enddate><creator>Bretan, Peter N.</creator><creator>Vigneron, Daniel B.</creator><creator>Hricak, Hedvig</creator><creator>Tom, Raymond A.</creator><creator>Moseley, Michael</creator><creator>Tanagho, Emil A.</creator><creator>James, Thomas L.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198902</creationdate><title>Assessment of male infertility: Correlation between results of semen analysis and phosphorus-31 magnetic resonance spectroscopy</title><author>Bretan, Peter N. ; Vigneron, Daniel B. ; Hricak, Hedvig ; Tom, Raymond A. ; Moseley, Michael ; Tanagho, Emil A. ; James, Thomas L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-d00480a2b5f0c0cc15c1ed4b3d6ed5a04749f1f4ed19850b7e31106406a148943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Glycerylphosphorylcholine - analysis</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infertility, Male - diagnosis</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Semen - analysis</topic><topic>Sterility. Assisted procreation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bretan, Peter N.</creatorcontrib><creatorcontrib>Vigneron, Daniel B.</creatorcontrib><creatorcontrib>Hricak, Hedvig</creatorcontrib><creatorcontrib>Tom, Raymond A.</creatorcontrib><creatorcontrib>Moseley, Michael</creatorcontrib><creatorcontrib>Tanagho, Emil A.</creatorcontrib><creatorcontrib>James, Thomas L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urology (Ridgewood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bretan, Peter N.</au><au>Vigneron, Daniel B.</au><au>Hricak, Hedvig</au><au>Tom, Raymond A.</au><au>Moseley, Michael</au><au>Tanagho, Emil A.</au><au>James, Thomas L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of male infertility: Correlation between results of semen analysis and phosphorus-31 magnetic resonance spectroscopy</atitle><jtitle>Urology (Ridgewood, N.J.)</jtitle><addtitle>Urology</addtitle><date>1989-02</date><risdate>1989</risdate><volume>33</volume><issue>2</issue><spage>116</spage><epage>119</epage><pages>116-119</pages><issn>0090-4295</issn><eissn>1527-9995</eissn><coden>URGYAZ</coden><abstract>To evaluate the usefulness of phosphorus-31 magnetic resonance spectroscopy (
31P-MRS) in assessing male infertility, we compared it with conventional semen analysis. Specimens were obtained from otherwise healthy patient groups as follows: group A, 7 fertile control subjects; group B, 12 azoospermic men after vasectomy; and group C, 11 patients presenting for infertility evaluation. Correlations between established semen analysis parameters and the
31P-MRS-derived ratio of glycerylphosphorylcholine to total phosphate (GPCITP) were investigated. Group A controls had a mean GPCITC ratio of 0.10 ± 0.05, which was the same as that of group C. With the exception of significantly lowered motility and normal morphology in group C (p < 0.001 and 0.05, respectively) semen analysis parameters in these two groups were similar. In contrast, the GPC/TP ratio in group B (0.05 3NA 0.04) was significantly different from the control (p < 0.05), which appropriately reflected complete vasal occlusion. The results suggest that a significant portion of seminal GPC is derived from epididymal secretion and that
31P-MRS is useful for monitoring the GPC/TP levels when assessing epididymal function and male infertility.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2916284</pmid><doi>10.1016/0090-4295(89)90007-1</doi><tpages>4</tpages></addata></record> |
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| subjects | Biological and medical sciences Birth control Glycerylphosphorylcholine - analysis Gynecology. Andrology. Obstetrics Humans Infertility, Male - diagnosis Magnetic Resonance Spectroscopy Male Medical sciences Semen - analysis Sterility. Assisted procreation |
| title | Assessment of male infertility: Correlation between results of semen analysis and phosphorus-31 magnetic resonance spectroscopy |
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